HairClone Cont., KROX20 Discovery: Weekly Thoughts 5/23/17

Hello Everyone,

Welcome to a new edition of Weekly Thoughts. I’ve got some details to share on how things are going at HairClone these days, as well as notions on two promising studies on genes involved in hair growth. One of the studies has had the internet ablaze lately with KROX talk. It’s surely a wonderful discovery, though it may be some time before we hear more about it. The other gene therapy discussed is a bit more of a surprise. Let’s see what’s going on.

The HairClone Zone

Over a month ago, a video was released through a local Texas news station detailing the current progress of HairClone. The video features Dr. Ken Williams, a clinical partner of HairClone, discussing the option of administering HairClone’s new technique on one of his patients. Video seen below:

The video also mentions HairClone is planning to begin a small clinical trial towards the end of 2017, which is good news. But what’s better than some news? More news. I’ve got the latest here from HairClone CEO Paul Kemp on what is currently at hand for his company, and also some commentary on the video that was released:

“The video came out of contacts the media had directly with Dr. Ken Williams who is one of our Founder Clinical Partners and who we are really pleased to be working with.  He is helping to support the work we are carrying out now and he will be involved with us once we are running clinical trials.  

The clinical work that we are doing at the moment is to better understand the clinical response of non-expanded hair follicle cells, how best to implant them and how to monitor the results.  This is already providing us with some critical lessons and will also direct the cell expansion studies which we are about to begin.  We are also working with a licensed UK cell bank to help set up our follicle banking service and are working with Claire Higgins to optimize the cryopreservation protocol we will use so that we can recover all the various follicle cell types.  

We have had a lot of interest from people about equity crowdfunding and we did spend a lot of time discussing this with a crowd funding platform in Belgium. However, the financial regulations there did not seem to be the most appropriate to what we are trying to achieve and we decided not to use them. We are still active in this area and hope to have a campaign up and running in the summer.

We are extremely pleased with how things are progressing and proud of the clinical and scientific network that we have already established and we will be making a series of exciting announcements throughout the rest of this year.”

Anyone interested in equity crowdfunding HairClone? Stay tuned for more on that and other HairClone developments coming later this year.

KROX20 a Major Factor

It’s been a popular news item recently, researchers at the University of Texas led by Dr. Lu Le have identified two proteins that play a major role in the growth and pigmentation of hair follicles. This research follows suit with other significant hair growth discoveries of years past – the scientists were studying a different biological target (cancer) and then came across the hair growth observations “accidentally.” The two proteins identified in this study were KROX20 and “SCF” or Stem Cell Factor. When the scientists removed SCF from hair follicle progenitor cells, the hair that grew on the mice was gray and eventually turned white. When scientists removed KROX20 from the cells, no hair grew at all.

A therapeutic target of this research could be to look at ways of turning on the gene responsible for producing KROX20, or if only pigment is needed and not hair itself, turning on the gene responsible for SCF. Lead researcher Dr. Lu Le announced in the original article: “With this knowledge, we hope in the future to create a topical compound or to safely deliver the necessary gene to hair follicles to correct these cosmetic problems.” At this time, we don’t know how long that could take. It could be a little while before more trials begin, but I certainly wish Dr. Le and his team congratulations on this research and a lot of expediency for their further developments.

COL17A1 – New Development

In February 2016, Emi Nishimura and researchers identified Collagen17A1 as a key gene which keeps hair follicles cycling healthily. Nishimura et al. noted that DNA damage lead to a depletion of COL17A1 in older hair follicles. When older hair follicles lacked COL17A1, some of the hair follicle stem cells would turn into skin producing cells instead of hair follicle producing cells. Thus, a sufficient amount of COL17A1 in the hair follicle is necessary to keep hair growing and cycling. I found this research particularly interesting when it was released and theorized that creating a therapy to increase levels of COL17A1 in hair cells must be underway.

While doing research in the Follicle Thought lab earlier this week I discovered Emi Nishimura had done an interview with our old friends Aderans sometime over the past year. The interview was based around Emi’s COL17A1 research. Fitting in with the theme of this Weekly Thoughts, Nishimura explained in her interview that COL17A1 also plays a role preventing gray hair. This is based on the fact that hair follicle stem cells are responsible for keeping the melanocyte cells functioning properly, and when hair follicle stem cells are affected by lack of COL17A1 this too can lead to gray hair.

I was excited to read near the end of the interview, Nishimura is currently looking into therapeutic avenues to address COL17A1 suffiency in hair follicles. She stated:

“Accordingly, we are examining the possibility of reducing hair loss through the inhibition of degradation of collagen XVII by inhibiting neutrophil elastase. We are also conducting research for a drug to prevent collagen XVII from being decreased or to increase it.”

It is hopeful that one of those three potentials will be fruitful. I hope to hear more on this in the future.

Until next time, be well.


Anonymous Scientist, get in touch.*

Kelopesia – ReBoost Update: International Shipping Available

(Originally published 02/17)

I got some great news today, everybody, that I am excited to share with you all.

Prof. Fikrettin Sahin gave me an update on the Turkish hair cream that has many people on the edge of their seats. The update includes a new release date and a new name for the product. Here is the info from Prof. Sahin himself as of 2/20/17:

“Our hair cream will be introduced into the market soon (within 2 weeks). Commercial name of the product will be ReBoost.”

ReBoost….hmmm. Interesting name. I was also told by Prof. Sahin that after the release of the product in Turkey, he will let me know how the cream may be purchased from Turkey by those who live abroad. Rest assured, you will all get that info when it is available. Making sure you are subscribed for email updates on the right sidebar of this blog is a good idea. Other than that, smile. 🙂

To Prof. Sahin and the rest of the team who worked on this product – Thank You!

Update 3/3/17:

We are now close to the time period in which Prof. Sahin stated ReBoost would be launched in Turkey. In lieu of inquiries about the progress of the launch I am making this statement to my readers:  Thank you very much for your patience as we anticipate the launching of a potentially pivotal treatment for hair growth. As has been stated on this site before, Prof. Sahin and his team have been working diligently to get this product to market. Let’s give them time to get it done and respect the time it may take to be completed. As with all project completions in life, exact dates are subject to change. If I do not receive an update sooner, I will contact the company for information towards the end of next week. I have no further information until I receive an update from the company. Thank you

Update 3/23/17:

I have still not been able to get another official update from the ReBoost company, yet. I just wanted to check in with you all because I realize this has seemingly been a while to wait for news. A friend of mine who lives in Turkey informed me that he contacted the University via telephone this month and they told him things were still progressing for the hair cream, with just a few more regulatory passages needing to be cleared in order for the cream to launch. For now, I will continue to wait for an update from the company and will be moving forward with new posts and topics. Thank you all for your patience.

Update 4/24/17:

Suffice to say, things have not gone as expected for ReBoost over the past two months. There has not been an official word from the company since the initial announcement of its launching. I am now uncertain as to whether the cream will be sold worldwide as foretold. Because of the lack of communication from the people behind ReBoost I am now moving past the subject and will only revisit it if I hear back from an official source or the cream does in fact launch in Turkey.  My apologies to everyone who is disappointed by this turn of events, the initial announcement came directly from the company and what has transpired since then was unexpected. Let’s stay positive for many of the other great products working towards release.

Update 5/2/17:

A new article has been published today in Turkey featuring Kelopesia/ReBoost. I still do not know what the future holds for ReBoost, however, this is official news with new data on the cream. Below is one of the newly released images of Reboost results.

pdate 5/5/17

The cream has officially been released in Turkey and a reader of the site has shared some pictures of her ReBoost bottles, “back to the roots” it says on the package 🙂 (Thank you Gizem)

As I’ve said, the cream has only been released in Turkey for now. According to the recent Turkish article, there was a production run of 10,000 units of ReBoost which are available for sale at the Yeditepe University. Sometime over the following months there will reportedly be announced an international online distributor of the cream, but we don’t know when. As we have learned over the past several months, things come out, when they come out.
*When I do hear of a way to order the production internationally, I will share that information in an update for this article.

Update 5/17/17:

I have just received word from my ReBoost contacts that international shipping for ReBoost is ready to go. Here is the information that I have for now:

ReBoost international sales started today and the transport process will be done with TNT International Company. Shipping costs will be added to total order amount, but if you order 3 or more ReBoost, shipping will be free. 

ReBoost International prices: 85€ or $100 (plus shipping).

Authorized companies for International Sales:

Yeditepe Saglik A.S and Marge Medical Ltd.

– Greetings Nurcan & Gizem!

I’m delighted at this news and hope you are as well. Let’s see how things go.

Update 5/19/17

I have received an official statement from the head of manufacturing of the ReBoost cream regarding its contents:

“To whom it may concern,

ReBoost is a hair product developed in Biotechnology and Stem Cell research laboratories at Yeditepe University, Istanbul, Turkey. The name of the hair cream has defined as Kelopesia firstly, therefore it is then decided to be named as ReBoost regarding to the opinions and suggestions coming from the sector experts. ReBoost has formulated as a result of a long-term scientific study. 

First of all, the molecular content of the discharged exosome (nanoparticle) of stem cells obtained from the foreskin was established and identified. These exosomes were determined to have a significant effect on the renewal of hair follicle cells. Then, the molecules that are approved for the production legislation of the cosmetic products were listed with respect to the Ministry of Health in Turkey. These molecules were studied and combined  with other important components such as vitamins, minerals and some hairdressing herbal oils for manufacturing the final formulation of ReBoost.

In May 2017, ReBoost was released to the market in Turkey. It can be ordered from Yeditepe University, Yeditepe Healthcare Inc. Marge Medical Ltd. or selected points of sale in Turkey.

Hakan ÇINAR – Bilimsel Mobile”

Follicum Phase 1/2A Hair Growth Results

Two days ago, I received an email from one of my readers which informed me that Follicum had just made an announcement about important developments that would be of interest to me. Upon further investigation, I found the Follicum website (only on the “Swedish” content) had put out a press release pertaining to the results of their candidate FOL-005 in its latest phase 1/2a trial. Read More

Anti-Aging Peptide, Replicel Check-In: Weekly Thoughts 4/7/17

Hello Everyone,

It is good to be back for another Weekly Thoughts. This edition is headlined by an anti-aging technology from The Netherlands that has shown interesting regenerative effects on mice. I even got some exclusive info on the potential of this technology to be applied to hair growth to share with you. Also, we get an update on how Replicel’s treatment has faired on people’s scalps five years after the injections. And while we are still looking forward to an update on a particular hair cream coming out of Turkey, I have some good news about another cosmetic hair cream that may be of interest. Read More

HairClone in Action, Scar Prevention: Weekly Thoughts 2/4/17

Hello everyone,

Welcome to another edition of Weekly Thoughts. I’ve been looking for some significant info to share with you all and today I came across just that. I expect this news to create quite a positive ripple in the hair enthusiast crowd. Let’s see what’s going on.

HairClone Begins

Dr. Bessam Farjo tweeted this photo today:

Read More

2017: A Look Ahead

I’ve got a good feeling about 2017…

For the past several years we have been pacified by the news of a research study or startup company working on a treatment that grows hair. Ultimately, we would prefer the treatment in our hands, but reading about it on a computer screen has been supportive as well. It’s something we can think of throughout the day or in a quiet moment which helps to release a little more serotonin in the brain. However, the time has to come for a treatment to be made available for us all and I believe that 2017 is going to be that year. This will mostly take place in the cosmetic market, but the treatments should be worthwhile. Read More

Kelopesia Update, Brotzu Trial, Cures: Weekly Thoughts 12/16/16

Hey everybody, welcome to another edition of Weekly Thoughts. This week I touch on two topicals that have been at the forefront of hair growth enthusiasts’ attention this past year. Also, I take a look at an intriguing healthcare legislation that was just passed this week in the United States.

Kelopesia Update

Remember when Kelopesia burst onto the scene earlier this year? Man, that was a hoot. It was slated as a new ‘stem cell-conditioned media’ cream which would be available by the end of April in Turkey. Well, turns out that was not the way it happened. We’re not quite sure what lead to the delay, but that’s not really important anymore. What’s important is that we are actually close to the re-scheduled release date of Kelopesia. This past week I decided it was a good time to get an update from Yeditepe University. Read More

RiverTown Therapeutics Inc. Launches Website

Today, I woke up to discover that one of my favorite companies developing a hair growth treatment, RiverTown Therapeutics Inc., has launched their website. Site can be viewed here. Read More

2016: A Year in Review

It does not feel that long ago that I wrote the article 2016: A Look Ahead, but just like that here I am bringing a recap of a rather exciting year in the hair growth industry.

To start, let’s review what I highlighted in the original “2016 look ahead” post. Read More

HairClone Growing, Aclaris IND: Weekly Thoughts 11/9/16

Hello everyone, and welcome to another edition of Weekly Thoughts.

It has been a little while since my last check in with you all. You can chalk it up to a busy schedule and the fact that there hasn’t been too much significant news in the hair growth treatment world recently. As always, there are positive developments happening behind the scenes. Let’s take a look at what has popped up in the past couple weeks. Read More