Ultimate Guide to Hair Regeneration 2016

Updated September 2016

This post contains a list of the most viable and relevant hair regeneration treatments that are known about. This list contains treatments which are in the development process. Certain treatments have a greater potential than others to grow significant amounts of hair, and so I have listed them in order of relevancy. Relevancy in this case is my opinion of the treatment’s combined efficacy and likelihood of becoming available the soonest. #1 is the most relevant and so on.

1. Shiseido/ReplicelReplicel’s hair growth treatment, RCH-01, involves culturing a person’s own hair follicle cells and then re-injecting them back into their scalp. First, a small punch-biopsy is removed from a person’s healthy hair follicles. Then a specific cell is dissected from the follicle and cultured in a growth medium. The cells are replicated into the millions and then injected back into the person’s scalp. There is a short video about the procedure here. Replicel has been involved in a lot of activity over the past years in terms of developing their RCH-01 treatment into a worldwide success. For starters, Replicel created a partnership with Shiseido, which is the fourth largest cosmetic company in the world. In May 2014 Shiseido opened a huge biotechnology facility in Japan to accelerate the launch of Replicel’s hair technology RCH-01. This endeavor coincides perfectly with Japan’s new legislation which is designed to help expedite the trial processes for stem cell technologies. In other words, Japan is the ideal place to launch a new stem cell technology. To be clear, Shiseido and Replicel are separate companies. Replicel has licensed Shiseido the rights to bring RCH-01 to the world more quickly through Japan. It is worth mentioning that Shiseido also has its own scientists who are working on hair regeneration through iPS cells. This technique is considered a “next level” type of cellular treatment that could produce an unlimited amount of hair regrowth.
Points of Interest: Shiseido is currently trialing Replicel’s RCH-01 in Japan for market approval by the end of 2018. Replicel is also planning on launching its own RCH-01 Phase 2 trial sometime in 1st half 2017 for approval in North America.
Status: Shiseido’s Japan trial is launching now 3rd quarter 2016. Estimated market release by 3rd quarter 2018.

2. Histogen Histogen’s Hair Stimulating Complex (HSC) is a cell conditioned media that is derived from neonatal cells grown under embryonic-like conditions. It is an injectable serum that is used to stimulate the growth of new hair follicles as well as existing ones in a person’s scalp. This treatment has been around since 2008 and a lot of people are eager for it to be released on the market. HSC has shown visual evidence of its efficacy and has had great numbers in clinical trials. No photo was more talked about than this one which was released after CEO Gail Naughton presented at last year’s World Congress for Hair Research. Compared to its initial inception, the HSC product has been refined over the past few years to contain less cellular impurities and be a more concentrated formula of growth factors.
Points of Interest: This is a treatment that has a very high appeal due to its ease of application. Theoretically, you could walk in, receive injections, and walk out. No need to harvest your own cells and come back to get them re-injected such as with other cellular based treatments. The photo results are intriguing and apparently the actual treatment will include more injections than the trial amount. This product could be out in 2017.
Status: Phase III trial for approval in Mexico could be underway currently. Histogen is also presently looking to launch a trial for approval in Japan and China. Set to be on the market in Mexico in 2017.

3. Brotzu Lotion This hair growth treatment went from being internet speculation to #3 on the Ultimate Guide list in record time. The “Brotzu Lotion” is a product that has been created through the work of Dr John Brotzu, a vascular surgeon from Italy. This hair growth treatment was discovered when Dr Brotzu was testing a formula to treat vascular insufficiency in patients with diabetes. It was noticed that this treatment regrew hair on the patient’s legs which lead Brotzu’s team to trial the formula on people’s scalps. The formula was modified to use DGLA instead of PGE1 because DGLA would not be classified as a drug and would require much less clinical trials to be approved. The known ingredients of this lotion include DGLA, Carnitine, S-equol, and Cationic Liposomes. The pharmaceutical company Fidia has acquired the rights to manufacture the Brotzu formula and is apparently performing a clinical study with the lotion for use in people with AGA. The study is being done in 2016 and if all goes well Fidiawill make the lotion available in early 2017.
Points of Interest: Dr Brotzu has been a well known and reputable vascular surgeon in Italy for decades. All of the science adds up and the fact that Fidia got involved seals the deal. Dr Brotzu has also released a compelling photo of a young girl with alopecia areata this year who used the lotion and got impressive results. The fact that it could be out as a cosmetic in early 2017 is striking. All eyes are on this treatment.
Status: Clinical efficacy trial is being completed in 2016 with the potential for a release in Italy in early 2017 pending results.

4. RiverTown Therapeutics Inc. RT1640 is composed of minoxidil, cyclosporine-A, and a novel drug RT175. This compound has been developed by the founder of RiverTown Therapeutics Inc., David Weinstein MD, PhD. In a Phase 1 trial 100% of the people who used the treatment had satisfactory hair growth and, reportedly, several people had complete hair regeneration. RiverTown Therapeutics debuted their fantastic hair growth results, found on the link above, on Follicle Thought. The three agents in RT1640 act on distinct pathways of AGA and synergize to promote the growth and maintenance of hair follicles. RT1640 also reanimates the melanocytic progenitor cells which give hair it’s color, and hence RT1640 restores pigment to regenerated hair as well. Interestingly enough, RT1640 was brought to life through it’s founder’s own interest to restore his hair growth.
Points of Interest: These results for RT1640 are the most significant hair regeneration results I have ever witnessed for a topical treatment. Not only does RT1640 regrow hair, it also restores the pigment to the hair it regenerates. The strong safety profiles of the three agents that compose RT1640 should benefit the clinical trial process.
Status: Currently raising funds for a Phase 1B/2A study.

5. Tsuji-Riken/Organ Technologies Dr. Takashi Tsuji runs one of the most advanced stem cell labs in the world at the Riken Institute in Japan. Thankfully, he took up the task of using stem cells to grow hair in his R&D and subsequently got some major partners to help further his work. In mid-2016 it was announced that Riken would be establishing a joint venture with the electronics company Kyocera and the regenerative medicine company Organ Technologies to bring Dr. Tsuji’s hair regeneration treatment to the market. In the joint venture Kyocera will be developing the cell processing devices and RIKEN and Organ Technologies will be responsible for the stem cell culturing and manipulation, the production process, and implementation of the preclinical trials. The treatment involves extracting a small number of hair follicles from a person’s donor scalp area and then isolating two specific types of cells from the follicle – papilla cells and epidermal cells from the bulge region. These cells are then cultured, expanded, and combined to create a hair follicle “germ” or “follicular primordium.” Once the hair follicle germs are ready they are transported to a facility where they can be implanted back into a person’s scalp to grow hair.
Points of Interest: Tsuji has been doing hair follicle research for several years now and it’s awesome that the strategic partners are finally in place to bring his hair growth treatment to the world. Organ Technologies will be develop this treatment in Japan by which currently has the fastest track to market approval in the world for cellular therapies. Kyocera has announced that they aim for this treatment to be on the market in 2020.

Status: Currently undergoing research and development with a goal of market release in 2020.

6. FollicaKnown for being one of the quietest companies on the horizon of hair growth treatments, Follica is also one of the most anticipated. Follica was founded around 2008 and was based on the science of creating hair follicles through creating tiny wounds in the scalp. Since their original clinical trials that did not bring about the desired results Follica has continued it’s research and development on combining novel compounds with micro-wounding for the proliferation of hair follicle formation. Follica has also announced that they are developing an at-home system to be combined with their out-patient micro-wounding therapy for hair growth.
Points of Interest: Follica’s founder Dr. George Cotsarelis is one of the household names in the hair follicle research world and has an array of hair growth related patents under his belt. About 8 years deep in development, Follica is planning to initiate a pivotal trial in late 2016/early 2017 which, pending results, could lead to Follica’s hair growth therapy being approved for the market sooner than later. In October 2016 Follica rolled out a new website that depicts a smartphone app to be coupled with their therapy regimen. The treatment, though not fully disclosed yet, stands to be a brief and tolerable procedure.
Status: Aiming at FDA clearance in 2017 for a commercial release in 2018.

7.  FollicumFollicum is a Swedish biotechnology company that is developing human peptides for the use of stimulating hair growth and inhibiting hair growth. The lead candidate peptide that Follicum is called FOL-005. Specifically, it is called FOL-S-005 when being used to stimulate hair growth. Yes, interestingly enough, the same peptide is used to grow hair and also inhibit hair growth. According to the CEO of Follicum, Dr. Jan Alenfall, various factors will decide what effect is attained from FOL-005; some of these factors include dose, the way it is administered, and the type of hair follicle being treated. It seems to me that Follicum has the ability to control the effect of it’s peptide well in hand. FOL-S-005 will be commercialized as a topical solution according to Follicum’s website.
Points of Interest: Follicum has initally been very kind to Follicle Thought and debuted a graph of their pre-clinical trial results on this site. The hair growth effect of their peptide was originally observed in mice in 2004, accidentally. This means they’ve had 11 years to conduct R&D on this discovery. Follicum has been working with renowned hair researcher Ralf Paus since 2012. They’re initiating human trials which are set to begin early 2016 and have secured two major manufacturing partners for their peptide technology.
Status: Beginning Phase 2A trial in September 2016

8. Clinica FCS (Stem Cell Transfer)Christophe Guillemat of the CFS Barcelona Hair Transplant Clinic has been researching a method of extracting hair follicle stem cells from the donor area and utilizing them for hair transplants. I’ve previously made a post about this trial when it was first announced. Guillemat’s method appears to be a similar in concept to the one used by Dr. Gho. At the beginning of summer, the doctor announced that he had begun a trial with 20 patients after he saw good results in his first ‘test’ patient. The results from the 20 patients were set to be announced in September 2015, but it appears he is conducting another round of treatments on the same 20 patients to determine if his method does indeed leave intact an unlimited donor availability. Presumably, the cells that he is injecting to the recipient area are currently growing hairs.
Points of Interest: It’s still in the development phase. The results from the 20 patients should be known by mid 2016. The initial trial done on one patient, which is depicted here, showed good results. If Guillemat can achieve his goal of unlimited donor availability and share the technique with other respected doctors, we will be at a whole new level of hair restoration. Here’s the latest information about the technique.
Status: Trial results have been released and the procedure showed efficacy, however, the clinic is now working to improve their results before offering the procedure to patients.

9. SamumedSM04554 is a small-molecule topical solution that activates the Wnt pathway to grow hair. In March 2016 Samumed presented their highly anticipated Phase 2 results at the American Academy of Dermatology. The Phase 2 results got a mixed response from the online world of hair growth enthusiasts, but the bottom line is that the treatment grew hair in the trial. Approximately a 10% overall increase in hair density was observed in the best responding group who used SM04554. Before the end of that study, Samumed initiated a second Phase 2 study with a scalp biopsy analysis to better understand how their molecule gets the hair to grow. The initial Phase 2 trial lead to the conclusion that this drug does not contain a “dose response” in patients who use it. This means that adding more of the drug does not lead to more results. Finding the “just right” dosage and application is important for this drug to work it’s best.
Points of Interest: Samumed began by breezing their way through clinical trials and completed an important Phase 2 within about two years time from their initial startup. Now the company is looking into ways to optimize it’s drug to grow hair without a dose response and get to a Phase 3 trial.
Status: Have recently completed the biopsy analysis Phase 2 trial. Next step is yet to be announced. 

10. Allergan – Bimatoprost is a liquid topical solution originally used to enhance eyelash growth. It is the active ingredient in the product Latisse. Allergan has been testing Bimatoprost for hair growth on the scalp over the last several years. There have not been many announcements from Allergan during the course of the Bimatoprost trials, but there have been positive indicators. Also, in mid 2015 Allergan acquired Kythera Biopharmaceuticals, the company trialing Setipiprant for hair growth. This means Bimatoprost and Setipiprant are being developed under the same roof now. Bimatoprost is said to have a positive effect on PGE2 levels, while Setipiprant is a PGD2r antagonist. Hair loss researchers have theorized that those two effects would be an ideal combination for stimulating hair growth. Allergan has developed a new Bimatoprost formulation for the scalp in 2016 which has been enlisted in a new clinical trial process.
Points of Interest: It’s a product that has already been FDA approved to grow a type of body hair, eyelashes. Allergan has plenty of funding to get the trials done as quickly as possible. If all goes well, this should be out sooner than later. And, if Bimatoprost has no side effects and has similar growth results as Minoxidil or Finasteride, it’s a winner. It theoretically couples very well with its new in-house hair growth teammate Setipiprant.
Status: Phase I trial for new formula to be completed in October 2017.

11. Kythera Biopharmaceuticals Setipiprant is an oral medication or pill. Specifically, it is a prostaglandin 2 receptor (PGD2R) antagonist. It was previously developed for medical applications aside from hair loss and has undergone clinical trials. After George Cotsarelis at UPENN discovered that PGD2 receptors potentially play a major role in hair growth, Kythera began pre-clinical trials with Cotsarelis’ office to determine if PGD2r antagonists were worth developing as a hair loss treatment. About two years later, Kythera announced it acquired the rights from Cotsarelis to use Setipiprant as a hair loss treatment. Setipiprant is now undergoing a Phase IIA clinical trial in which finasteride is one of the control vehicles. The study is to be completed in September 2017.
Points of Interest: Setipiprant has already undergone a Phase III trial in the US. This should cut out a large portion of the time it usually takes to undergo the typical FDA trial process.
Status: Undergoing Phase IIA clinial trial with a completion date of September 2017

12. Dr. Colin Jahoda & Dr. Angela Chrisiano Two of the most prominent names when it comes to hair follicle research. Dr. Jahoda’s latest public work has been focused on 3D dermal papilla culturing, while Dr. Christiano has been popping up frequently in news headlines for her research on JAK inhibitors and hair growth. Even better, the two of them are reportedly teaming up on Christiano’s new startup “Rapunzel” which is developing a treatment using cultured hair follicle cells to regenerate hair. It is a popular approach these days and I am very interested to see what these two pioneers come up with.
Points of Interest: Dr. Jahoda implanted his own hair cells into his wife’s arm and found that the cells grew hair on her arm all the way back in 1999. Currently, it has been reported that his 3D method is being trialed in Taiwan. Hearing the results from those trials will be extremely interesting. Dr. Christiano has been gaining some momentum with the recent finding that Ruxolitinib is a potential full on cure for alopecia areata.
Status: Dr. Jahoda’s study will conclude December 2016. Dr. Christiano has recently sold her JAK IP to Aclaris who is carrying out the trials for use in AGA.

97 thoughts on “Ultimate Guide to Hair Regeneration 2016

  1. Thank you for keeping us all updated. My daughter started to loose her gorgeous red hair when she was 14 years old..She’s now 25! …… Very thin spare hair left…. Tried everything.. Including FUE and all oral medications… Trying ACELL PRP injections next month… We are still hoping for a cure!

    • Hello Sheila,
      I very much hope that good things come for your daughter. She is lucky to have a dedicated and caring mother like you who is actively seeking a cure on her behalf. Not everyone has someone like that in their life. I know it might not sound like great consolation at the moment, but I can say confidently that your daughter will not have to go through her 30’s with the same struggle. The new technologies are coming and will be here soon. Keep the faith.

      Best Wishes,

      • She’s completed the full head prp treatment.. Doc says he sees some improvement.. We don’t see it… He says need a full year… Getting very frustrated… May be time for a hairpiece until something starts to change 😩

  2. This is a great compilation of hope for those of us suffering from hair loss. Thank you.

    Sheila, how did the A-cell PRP work for your daughter? Where did you go for the procedure?

  3. We did a test patch with Dr. Prasad. We are one month out. Too early to tell . He will check her every 3 months .. If he sees improvement then we do the whole head. The procedure wasn’t bad , aside from slight pulling feeing for a few days. No hair fell out so that’s a good sign cause some females shed a bit.
    My daughter is very far advanced in hair loss and Doc says he hasn’t treated a female with so much diffuse hair loss before, hence the test patch… Will let you know… We love the Doctor He was very honest and gave slot of his time..
    Sheila Mizrahi

  4. We did a test patch with Dr. Prasad. We are one month out. Too early to tell . He will check her every 3 months .. If he sees improvement then we do the whole head. The procedure wasn’t bad , aside from slight pulling feeing for a few days. No hair fell out so that’s a good sign cause some females shed a bit.
    My daughter is very far advanced in hair loss and Doc says he hasn’t treated a female with so much diffuse hair loss before, hence the test patch… Will let you know… We love the Doctor He was very honest and gave slot of his time..
    Sheila Mizrahi

  5. Hi, I didn’t been able of reading this article full yet.
    It is being hard of translating because english is not my first language, just I would like to know one of all these treatments would renew my hair cycle and return follicles to its actual thickness.
    I mean hair regeneration, because I have enough density but my hair is too thin right now.

      • When would these treatments come to Europe?
        I have seen some posts about Histogen on Bernstein Medical – Center for Hair Restoration in NY.
        Also, do you think that treament would be something definitive for hair regeneration?
        I´m from Spain and here there isn´t anything yet, only some stem cells (preventive treatments).
        Thank you

        • Hi M,

          I’m not sure when these treatments would be available in Europe, some places in Turkey may have a treatment before other places in the world, though. Asia will probably be the first of all.

          I think Histogen has shown that it can regenerate hair follicles, it is just not clear how much it can regenerate yet. Overall, it looks like a good improvement for hair treatments.


    • Replicel by 2018. Histogen in Asia possibly 2018. Dr. Christiano, no known release date. Of those treatments only Dr. Christiano’s may have known side effects.

    • Hi there,
      I’m aware of Dr. Tsuji’s work and am sure it could possibly be the biggest achievement of them all, I just do not have any word on what stage he is at of bringing his technology to a treatment. To be honest there are a lot of Asian researchers who have substantial ongoing hair growth research and I bet a few of them have funding partners, etc. secured for when their technology is ready to go. These things will be announced over the next 1-2 years, I guess. Tsuji will definitely be on this list soon, perhaps when there is another update from his lab.

  6. Hi All

    Good to see. I am 27 years old, suffered from male baldness. I would like to go through some treatment. What could be the best treatment for Hair regrowth in India.


    • Hi Sureshkumar,

      Other than a hair transplant, the treatments are the same throughout the world. Replicel and Histogen somewhere on the planet will be the best new hair growth treatments.

  7. Hi I want to thank you for the effort you put into this thing. You have educated me a lot on the issue of hair loss and this site is great for staying up to date on the latest matters in hair loss. Quick question, I am almost 25 and am at a norwood 2.5. I have seen good results with finasteride, have gotten a adipose stem cell fat transfer from stomach to hair, and regularly do PRP. Do you think I would be safe to get a HT done to my hairline given the new treatments that are around the corner? The traditional viewpoint was to wait until you are in your 30s, but I would like to get one now. Just wondering if it was as risky to get one as it was in the past given what we know about replicel and histogen?

    Thanks for your effort!


    • Hi Nick,

      Sorry for the delay in response. I don’t see the risk in getting a hair transplant in your mid 20s if it’s only going to be at your hairline. Most people have much more than enough donor capacity to fill in a hairline and more of the scalp. The new treatments being discussed today do look like they have the potential to be great adjunct treatments.


  8. Hi
    I am 32 now ..Norwood stage 3 ,is it worth to keep my follicle alive by finas , minoxidil& PRP,till replicell available in market or stop all this.

    • Hi Sheila,
      The real price is not announced yet. This news in the article is premature to be honest. It’s really not even worthwhile to discuss it at the moment. The location will be Japan, perhaps in early 2018, and I can all but guarantee it will be a bit more than 887 dollars.

  9. Hi, I´ve been looking for information about Hair Cloning.
    and definitely I feel hope again, looks like Angela Christiano research project would be the solution for my hair problem.
    Seems I´m not probably a good patient for hair transplant however I read hair clonning would works for everyone, including women.
    I’m right?
    just I need to know if this would be suitable for people with long hair.

    • Hi M,

      Hair cloning would presumably work for everyone, but I am not sure which treatment you are referring to. Long hair is not an issue for hair growth treatments.
      Histogen and Replicel are good potential treatments at the moment.

  10. Hi, I meant to the current research from Columbia and Durham University in the UK.(hair cloning)
    I asked to Doct Christophe about the possibility of using SCTransfer and he said that probably a hair transplant is not the most suitable in my case because I haven´t bald areas.
    My hair loss is diffuse.
    I know hair cloning isn´t yet available for people but I was wondering If there is already any official site expaining in which would consist, how much it would cost and If it is necesary being shaved for it.
    Also I´m a little confused about Histogen and Replicel.
    We are talking about the same process?
    Both come from diferent studies and countries.

    • Hi,

      I don’t believe there is a site like that yet.

      Histogen and Replicel are not the same. I’ve explained them pretty well in this post. Replicel has a video which shows the process. See above. Histogen uses baby stem cell proteins which are injected into one’s scalp.

      Histogen and Replicel are similar and will probably work together very well when combined.

  11. Have you ever heard about Regenerate Active?
    This new treatment is already available for patiens and reminds me to Replicel a little.

    Marbeclinic, Bonome, Dorsia clinic…

    What do you think about this?

    I wrote them asking about this new treatment and they said:

    “The Rigenera technology is based on tissue mechanical disintegration, getting micro-grafts from the patient, where there is a high concentration of pluripontentes cells with a great capacity for tissue regeneration, such technology is being used for several years in various specialties within medicine, dentistry, maxillofacial, vascular, etc .. in the field of cosmetic medicine mainly has it begun to implement in stretch marks, scars, keloids, facial revitalization, vascular ulcers, burns, wound healing and the newest is alopecia.
    Casuistry moment about it but limited clinical cases shown so far are very encouraging.
    Either way is necessary to know the characteristics of each patient prior to venture a final result.”

    • I have not heard of it, but I cannot say one way or the other if I think it will be good. I’ve never seen a company doing an extraction from someone’s neck before and then using those cells somehow. Usually the technique is done to remove fat from someone’s stomach and then inject the cells into the scalp. I recommend asking a lot of questions and be cautious. If I could speak Spanish I could be more help.

      • Thanks for asking, I know what you mean this is a new treatment available in Spain and there are already some clinics offering this regenerative therapy.
        Obviously I had some doubts because this is the first time I heard talking about it .
        I thought on Stem Cell Transfer and alopecell, because both have a very similar process.But this one looks easier and without side effects.
        The company is called Regenera Activa.

  12. hair cloning, hair multiplication, hair to produce stem cells.
    In all of these solutions will be a very difficult cancer risk
    Do you have any idea?

    • Hi Tolga. I attended the 9th World Hair Research Congress in Miami last Nov. 2015. When asked, the researchers mentioned that with human studies and the Wnt pathway which stimulates hair follicles, they have to be very careful because the same pathway is related to squamous cell carcinoma of the skin. This probably makes human studies more involved and also more expensive to research.
      I am waiting for good medical products to go on the market also. Hope this helps.

  13. Hey admin, I just wanted to let you know of some possible good news about Histogen for the end of this month.. I was surfing through stuff and decided to go on histogens website.. Anyways found one of their presentation videos on YouTube from October 2014.. Oddly enough I looked through the comments and a recent comment from Brian naughton (Gail’s son) posted a comment saying, ” I’m Gail’s Son’s girlfriend. Great new things are up and coming! Don’t worry! :)” Weird that Histogen has been silent lately but updated their website and announced a presentation at the stem cell summit this month.. Was wondering what you think about this. My theory is that we might get a final clinical trial announcement or something. Why else would we see that comment after such an old video?

    • Thanks for sharing Sam. Yes, it’s possible that Gail might announce the clinical trial at the Boston event. We will find out this month, I believe.

  14. Hi, do you know one of all these treatments is the closest?
    with a definitive release date announced.
    There will be something true effective for androgenic alopecia in 2016 or in the early 2017?

    Thank you

    • Hi Ana,
      Replicel could potentially be the earlier cellular based treatment on the list, but it would not be available until 2018.

      There is a good chance that topical hair creams that are able to grow hair will be available to consumers before then. Even in 2016.

  15. I think that a complete cure is so far at moment, but with which are gonna hit the market on this 2/4 years will solve the 80% of alopecias i think, as least a nw7 maybe could have a good enought hair for dont be a completlu bald.And after this treatments also u can do a hair transplant
    thats only my opinion, what do u think?

  16. Hey, i Have a question:
    Do u know the Follica release date? I am confused about that, and about why people dont trust on a cure
    Follica can give us new follicles, and imagine combine it with replicel and Histogen, and sammued and hair tansplant, i think is crazy to be sad , a cure is close, but i am not sure about dates, i hope replicel for 2018, Histogen 2017¿?¿? and Follica? do u know something Joshep?

    • Follicle Thought

      Follica has said that is all goes well with their testing they will file for approval in 2017 for a commercial release in 2018. It sounds like they have been working hard behind the scenes to make advancements in their products.

  17. Any updates for Follica, Histogen, or Replicel on the horizon? I’ve used proscar for 5 years and I’m diffusing again, and have thrown rogaine foam and keratin fibers in just to maintain. But barely. I’m getting that cancer patient look, and my head is such a terrible shape I can’t shave it. Dermatch gets all over my gfs pillows and looks weird to me. Please let something come out within the next 18 months!!

    • Follicle Thought

      Hey Biff,
      All those treatments you mentioned are looking to be around the 18+ month mark, but I really am optimistic about a few topicals that have the potential to be out before then that can maintain and possibly produce decent growth, namely Kelopesia, Brotzu lotion, and possibly others. I know the waiting isn’t always the most fun, but at least there is hope. Replicel and Histogen seem to be working hard behind the scenes to get their trials setup, it does involve some work.

  18. Finally looks like Histogen will be released on 2018 and not 2017 🙁
    In another hand, do u know when are gonna hit the market kelopesia and Brotzu lotion?All i know is that kelopesia is gonna be realesed this year and lotion the next, but not the same to be on first months or the latest.

    • Follicle Thought

      I think you’re right Josh. It’s almost June and still no word of a trial launch for Histogen. As you know, predicting the launch of a product is a guessing game. A conservative guess for Kelopesia would be by the end of July and for Brotzu lotion, perhaps early Spring 2017.

      • Can u tell us how Keliopesia is applied? Is it drops or lotion??? And does it work for female pattern baldness?

        • Follicle Thought


          It appears to be a cream. Yes the inventor mentioned that it was more effective for females when tested. They are working on their manufacturing development right now, getting the product to be effective when stored at room temperature. Hopefully we hear something in July.

  19. (06/02/16) We have not heard anything new from Replicel or Shiseido for six months. No news of them starting their Phase II clinical trials. Is this not a good sign, or does anyone know anything different?
    I know that Histogen and Samumed are both going strong and are determined to get a product on the market, hopefully by the end of 2018. All three companies had their top people at the 9th World Hair Research conference in Miami in Nov. 2015.
    Also, hopefully Allergan can start testing soon for their PGD2 inhibitor (Kythera’s setipiprant). Last news was in Sept. 2015 when the company filed with the FDA to start testing.

    • Follicle Thought

      Thanks Bruck.
      My guess is that companies are fine tuning their trials before launching to get the best results they can. I remember Replicel mentioned after their first trial that they wanted to improve upon their cell storage and transportation in the future.

  20. For years there have been articles on breakthroughs on hair loss only to see these so-called miracle cures fade like the summer sun. I lost all my hair over 10 years ago and have come to accept that there will be no cure for baldness in my lifetime. This so called remedy is just more b.s that will never amount to anything. This will fade like Laminin 411 another brilliant breakthrough that never saw the light of day. I do get really tired of these articles that try to give a glimmer of hope but only end up making people such as myself bitter because when it’s all said and done and the smoke clears, there is no cure for baldness. That’s the truth!

    • Follicle Thought

      Thanks for sharing. I normally don’t allow comments with negativity towards the content of the site, but I can sense that you are sincere and have been hoping for a cure for a long time. Some things you have said are right, for all intents and purposes right now on June 6, 2016 there is no “cure” for baldness.

      And in 1901 there were no airplanes after many tries (first flight was 1903). In 1965 no one made it to space before (first journey to space was in 1968). Or in 2007 no one could have imagined a device that fits in your pocket and does more than a laptop anywhere in the world (iphone 2008). But all of these things prove the that technology advances over time. The cure for hair is inevitable if people continue to pursue, and they are.

      I’m not sure what age you’re at, but I do believe there is significant upgrades to hair tech within the next few years. Whatever you decide, I wish you well friend.

  21. Let’s be positive, I think the winner takes it all. Question is: is it a race over the 100 meter or over the marathon?

    • Based on the capabilities of the treatments listed, I think there will be room for many treatment options. They work in different ways and could presumably be combined.

  22. Hi, thank you so much for compiling this, it’s so informative

    My question is, are any of these treatments going to be effective for men with very advanced (Norwood 6-7) hair loss?

    I’m 22 and only just starting to thin, so I still have quite a full head of hair at this point, no major loss. However, men in my family do tend to go VERY bald, and I will likely go full Norwood 7 if I leave my hair loss unchecked. I’m currently attempting to stabilise any further loss using Propecia, and although I have only been on a few months it’s looking good, no immediate side effects and the shedding has decreased.

    I’m hoping for a breakthrough that’s going to make hair replacement much more possible for men with severe loss. It might not be an issue for me if I continue on the Propecia, but if I’m honest I don’t like the idea of being on Propecia for the long haul given the potential side-effects. I’d hope to eventually switch over to something more effective and less dicey with the long-term side-effects if the technology was developed to support it.

    • Hi Nick,

      Thanks for your comment and inquiry. At 22 still with quite a full head of hair and taking Finasteride, you are almost golden. I don’t see why you would even get to a NW6 or 7 at the rate you’re on. Some of these treatments, yes, will be effective for the advanced norwoods. But with a few key topical formulas set to be released within 2 years time your hair should be in good shape for a long long while. I believe there will be an option to get off the finasteride as well. The developments are coming. The ultimate guide is getting updated soon, stay tuned.

  23. Good day,
    I’m Farhad
    I’m a boy from Iran,
    I’m 32 years old
    I have hair loss about 14years
    My hair is sparse at the moment.
    I could control my hair loss a bit by taking medicine as following list:
    I use minoxidil 5% about 13 years, use Reigen Diet 8 years , used igrow and use 5 months Prosrin 3 tablets every day
    Before Prosrin I used Propesia about 10 years, but I don’t use Propesia right now.

    I did prp in iran 3 years ago but I didn’t work.

    I’m tired of taking medicine and I’m suffering from my hair loos.

    What do you think about stem sell, does it work in the case of me?

    Could you help me and tell me that what shall I do?
    Thank you very much in advance.

    • Hi Farhad,

      When new substantial treatments are made available to the public the announcement will be made on this blog. From there you can decide if you want to research what people are saying from experience about using the treatments and try the treatments if you want to.

  24. Hello, My name is Manal I am femal from Egypt. I strayed lossing my hair since one year. I went to see doctor and said that I have alpieaca. I take minoxidil 5% for one year and 2 months, but still loading my hair. I took another treatment like prp and Mesotheraby. I had tried everything like revivogen and alpicean drugs but no used. Since one year till one I lost my hair and keeping lossing. Also, I have grey hair since I was young all my hair is grey so I used hair color without ammonia. I left my work bez of my hair and get out of my friend and stay at home. I was working as Sr. Admin.as I got a high college degree Diploma Buds. Admin. I lost my life, my friend and my work bez of my hair. No treatment is working with me. And it is very costly without no used. I spent a lot that lost all my money. Also I married and that effect my relation with my husband as I refused to go out or see people. It is very hurting but I hope that a new drugs maybe give me a hope. So pls I need to know everything about the new treatment and the price pls. I am sorry for my long email and sharing this sad feeling but I am seeking for a hope. Thank you for understanding.

  25. I wanted to know if there is any possible date for the release of Replicel or Histogen HSC, I just started to notice that my temples were growing. I am 31 and I am in Norwood 1. I was told by the dermatologist that I had a mild form of ADA, and that if I didn’t take Minoxidil it will turn eventually into Norwood 2 or 3. Minoxidil worked really well by the 2nd month the temples are now covered again, but without the same density, I hope I have more density in the next 10 month, since my dermatologist told me that this effect will last about one year, and then it will only help me by loosing my hair slower. The problem is that facial hair in my forehead has grown, and I had to taked them out with a depilation device. Its not that I have become a wolf but you can notice it. I wish there was an option that did not involved those side effects.
    Do you think this new treatments can work for this kind of Alopecia.


    • I think that these treatments will very likely grow hair in the temples, and hopefully only exactly where we want it.


  26. Hey man, I’m 19 right now and it looks like my hair is getting thinner, my question is should I wait for these treatments or get on fin right now? Thanks.

    • I’m not as big of a expert as some of the people on here especially not like the admin. But I am 25 and have been on fin for just over a year. I have not noticed any side effects when it comes to my package. I think my hair has gotten better since I’ve used it, but it’s always tough to tell tbh. I still see hair come out in the shower a few strands but that’s normal. I would get on it,but only use it every other day like I do. 1.25 mg of fin every other day is my regime. Get on nizoral shampoo as well. Watch your package. If you see anything drastic then stop using it. If you get on now, you should be fine by the time these new treatments come around.

  27. Hi Nick,
    Thanks for d reply. Can u plz provide detils of fin like, what is d fulll name of fin and is it availavle in india?
    How it should be taken, like every other day in night? Did u find ur hair come back when u used it? How many days it took for u to see d results?

    • The drug is called finasteride. I don’t know if they have it in India. I take it every other night, sometimes I forget and take it every 3 nights. It’s not going to regrow hair that is already gone. But it’s thickened what hair I had left and I hope halted the process of further recession although I can never say for sure. But it’s definitely helped me.

  28. Hi there,
    I’ m in my 50’s and have lost my hair in a big area at around 20 years ago. I would like to know that when such treatments as “RCH-01” or “Histogen” would successfully enter into the market, will they work for me or not?
    I think that it might not affect on my head cause the lost folicles are no more existing in my scalp.
    Thanks and regards

    • Hi Razan,

      Thanks for visiting. At this point no one can really answer that question. Time will tell when more trial results have been presented by those companies. I believe I’ve heard both companies remark “It’s possible” when asked a similar question as the one you did.

      Stay hopeful

  29. I want to grow new hair .i search many website for this perpose but i surprised to khow that we have not discovered any injection for it. Or any medical treatment which is cheap or suitable for everyone. I have heard that one man transplanted his liver and some days later he had new hair on his bald. It means it is possible. Please scincetists dicover injection for grow new hair on hair. We can reach moon but why can’t we do this?

  30. Thank you for creating this website. While I’ve read a bit about some of this research, this is the only site I’ve found that has such a comprehensive up-to-date list of treatments being developed for hair loss.
    I’ve had lichen planopilaris for a number of years resulting in areas of scarring where the follicles have been completely destroyed.
    I’ve been advised that because of the scarring in some of those places, transplants won’t take due to an inadequate blood supply. This is where the scarring is more severe. However, some of the spots seem to have hair loss with either no or minimal cellular damage to the scalp and underlying vascular system. Most of the areas have reached the “end stage” meaning they are no longer active, although I’ve noticed new spots will show up every few years if I don’t consistently take Plaquenil.

    If I may ask, would any of these treatments work for someone with my condition? Specifically, could any of them also stimulate the growth of a new blood supply where the follicle growing cells are injected?

  31. A great summary article of the many companies/partnerships working hard on better, more sustainable hair loss treatments. With this many different methods being explored and some of the top players showing success, it makes it a lot easier to stay hopeful for what happens in the next 5-10 years. The L’Oreal / Poietis partnership to develop bioprinting of hair follicles might be worth watching as well.

  32. Thanks for the summary. Since most of these seem to regrow hair, would the user need to stay on propecia or just lose them again. For replicel, for example, do you go once every few months?

    Would any of these functionally replace propecia? Infinite donor hair wouldn’t require the drug, correct?

    Basically, do any of these offer a non propecia solution in the next 5 years?

  33. Dear Admin

    My son is 18 1/2 Year and experiencing diffuse thinning and Hairline receding
    Can he start finasteride safely to keep his hair until the new treatments are launched

    • Sure, Rod. There was a lot of uncertainty about Kelopesia over the last several months but now is confirmed to be released again by Spring. It will be on the list shortly.

  34. I had done 3 prp sittings…I am using sawbio tablets…. initially I have good hair only 20% lost .after minoxidil usage I have lost more… And I got jaundice during taking biotin…. suddenly shedding increased…I don’t know whtat to do…just shaved my head and stopped using all…..I am not going to do risky with my health…using propecia also waste of processes… after stopping minoxidil and propecia what you get will be lost…bonus side effects… being developed scientist can’t do anything…. simply plantation is also not a fullfill average man..but plantation also not complete successfull they will shed away…grow up scientist think about people not money….

  35. This was a great place to find some information about the current status of future developments. Thank you for investing your time and effort into putting all this information in one place.

    I myself have been taking minoxidil and fin for several years, with some results, at the very least it’s drastically slowed down my hair loss. I recently got a LLT helmet, but it’s only been 5 months, and my friend whose had great success with that, said he didn’t see real results for a year (mind you we have different models, so who knows if it will work) . Hair loss game is one of patience I suppose. I’ve thought about PRP but I have come to cast doubts of its effectiveness. Hopefully something new is release in 2017, if not I’ll do alright till 2018 I suppose. Look forward to seeing new updates!!

  36. Everyone is looking forward to RepliCel and I understand why but here is my issue. I have frontal scarring alopecia and the rest of my hair overall is thin. I use a blow dryer with the comb attachment everyday to get body/lift. I’m a man and its tiresome. When your hair is thinning there are common activities you can’t do comfortably like Swimming, working out, bike riding, hiking etc. Anything that involves humidity or sweat and I mean anything. If I go to work on a hot day or simply work up an internal sweat walking to the train station (any weather) it has an effect on my hair. I know how women feel when they say humidity kills their hair.

    Anyhow, enough of my sob story and to the point. What happens in my situation when the donor area is not bald but those follicles are weak?

    • Ken, I wish you well.

      I’m not sure of the answer to your question. But my question for this situation would be: if the follicles from a weak donor produced hair, and those new hairs eventually got weak and you had to do the process again to restore more follicles, would that work for you? There will be cosmetic products this year that improve hair strength.

      • Im interested in Replicel because I want to fix my hairline. The scarring has caused damage, thinning and balding in that area. If it works, I would be open to doing the procedure more than once but I wonder how effective that procedure would be if the donor area is weak.

  37. HI, just wondering if your aware of the status of histogen? Seems the closest to market but its gone very quiet.

    Also would you need to be taking fin for it to work? Or could injections in areas not yet lost help it be used as a maintenance option.

    Shame about brotzu being delayed!

    • Hi Rich,

      No updates on Histogen at the moment. I’ve never heard them mention that you would need to take Fin for it to work. Histogen believes it can be used as a maintenance option.


  38. Hi there,

    Thanks for this blog. I’m a 30 year old woman and I’ve been losing hair for the past three years. The hair loss seemed to start when I moved to London from Melbourne. I believe that the transition from soft water to hard water may have had something to do with this.

    I saw a dermatologist today and she believes that I have genetic female pattern hair loss. I am having difficulty understanding how this is possible given my relatively young age (I hear it’s more common in post-menopausal women) and the fact that hair loss doesn’t run in my family. She prescribed me minoxidil and spiro tablets.

    Can you advise of any alternative treatments that could help me? Could my dorm have been wrong? I don’t know where to turn. Any advice would be greatly appreciated.

  39. Hi,

    I am a female 40 years old, my hair is thinning all over the scalp and getting a less density in the frot top. I´ve tried vitamins, mesoherapy, PRP injections but no big changes. I’m stll looking for a solution and I believe celular teraphy with stem cels or germ folicles could be the one.

    Any news so far?

    • Thanks for visiting Mary. There is a news section of this site with the latest updates, whenever any promising treatment becomes available you will see it mentioned there. Best Wishes

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