Ultimate Guide to Hair Regeneration Pipeline 2023

Updated October 2023

This post contains a list of the most viable and relevant hair regeneration treatments which are in development. They can be referred to as hair loss cures, baldness cures, hair growth treatments, hair loss treatments, or cures for androgenic alopecia. The treatments listed in this guide are ranked by a combination of their estimated hair growth potential and estimated release date to the public market. Ranking #1 is the most relevant and so on. Rankings on the list are always subject to change depending on information that becomes available. Directly below is a pipeline chart of the most clinically developed therapies in the hair growth industry, plus a few selected promising therapies. The estimated launch dates range from a “best case scenario” to a likely scenario. Naturally, all estimated launch dates are contingent upon the treatment passing efficacy and safety in clinical trials.

1. Kintor Pharmaceutical – Kintor currently owns two of the more interesting AGA therapeutic candidates within their pipeline, pyrilutamide and GT20029. Pyrilutamide is a topical androgen receptor antagonist which is being trialed in both androgenic alopecia and acne by Kintor. This would put it in the same category as the drug Breezula. A published patent application (p. 85) for pyrilutamide claims that it outperformed known AR antagonist RU-58841 in a preclinical study to evaluate hair growth effect. Pyrilutamde may be the most potent AR antagonist currently in development for AGA. On February 1, 2021, Kintor announced its newer drug for hair growth, GT20029, which may potentially provide several benefits over existing anti-androgen hair drugs including pyrilutamide. Among them, Kintor claims that GT20029 may: 1) reduce the sensitivity of androgen receptors to androgens without systemic exposure to the drug, 2) maintain efficacy with small local administered amounts of the drug which can reduce dosing frequency compared to other small molecules, and 3) demonstrate greater efficacy than other AR small molecules without excessive drug accumulation and notable side effects.” Kintor plans to develop and launch both of these drugs in both China and the US.
Points of Interest: Kintor Pharmaceutical is publicly traded company on the Hong Kong stock market and has no problems financing both of their drugs pyrilutamide and GT20029 through clinical trials in both China and the US. Kintor’s newer drug for hair, GT20029, is a more advanced technology called an AR degrader which could pose less of a risk for potential systemic side effects. In August 2022, Kintor shared data from its phase 2 male pyrilutamide trial showing an increase of 22 non-vellus hairs above baseline.
Status: A Phase 3 trial of pyrilutamide in China completed enrollment in March 2023 and is expected to read out data in Q4 2023; a US Phase 2 trial shared data in May 2023. An additional long term safety Phase 3 trial began in China in July 2023. This pushes the potential release date of pyrilutamide back into late 2024/early 2025 in China.  A Phase 2 trial of pyrilutamide for females in China released data in December 2022.
A Phase 2 trial of GT20029 completed patient enrollment in August 2023 in China, while a US Phase 1 trial released positive safety data in February 2023.

2. TechnoDerma Medicines TechnoDerma’s TDM-105795 is one of the latest new drugs to enter clinical trials for AGA in the US. The company initiated a phase 1 safety trial in April 2021 and a follow up phase 1b trial in February 2022. TDM-105795 is classified as a topical thyroid hormone receptor agonst aka a thyromimetic. In other words, it’s a drug which mimics the activity of thyroid hormone.
Points of Interest: The lead candidate in TechnoDerma Medicines’ pipeline is TDM-105795 for AGA. This topical drug could replace or augment the use of the “gold standard” hair growth drugs, finasteride & minoxidil. The upcoming phase 2 trial results will be an important moment for the industry to gauge the potential of this new chemical entity to treat pattern hair loss.
Status: TDM-105795 was initiated into a Phase 2 trial in April 2023 which is estimated to complete in Q1 2024.

 3. Epibiotech (Stemore) – Epibiotech is a biotechnology company from South Korea which is a developing a wide range of therapies for hair loss. The company was founded by Dr. Sung Jong Hyuk of Yonsei University. Epibiotech’s primary target is creating an effective dermal papilla cell therapy. Dr. Sung and his team have completed numerous studies on dermal papilla enhancement and adipose-derived stem cell enhancement. In late 2019, Epibiotech completed an exclusive interview with Follicle Thought which explained the company’s therapies in great detail.
Points of Interest: Epibiotech has multiple therapies in their pipeline including topical drugs for hair growth. The company’s technology specializes in maintaining the hair growth capacity of dermal papilla cells, even after being cultured multiple times, which has previously been thought to be the major hurdle of DP cell therapy.
Status: Has filed an IND to begin a clinical trial for its dermal papilla cell injection therapy in Korea in 2023. In September 2023, Epibiotech CEO told Follicle Thought that a trial would begin by the year’s end.

4. Cutia Therapeutics – Cutia entered the the hair growth field scene in 2022. The company is an R&D pharma startup with a focus on dermatology and aesthetics. Its candidate therapeutic for hair growth is called CU-40101.
Points of Interest: Cutia Therapeutics has quietly entered the clinical trial level. The company appears to be affiliated with the massive Chinese pharmaceutical company Wuxi Apptec, which is promising for resources and support. Cutia’s CU-40101 is, in fact, licensed from Technoderma Medicines (p. 12), and is the same molecule as TDM-105795. Cutia has licensed TDM-205795 for its development in the Asian territory. A phase 1 trial is expected to complete in November 2023.
Status: A Phase 1 clinical trial in China began in August 2022 and is expected to complete in late 2023.

5. Hope Medicine – HMI-115 is Hope Medicine’s lead candidate compound, and is also its therapeutic for AGA. Hope Medicine is based in China and has licensed its hair growth technology from the global pharmaceutical Bayer AG. HMI-115 is a prolactin receptor (PRL) antagonistic antibody.
Points of Interest: The genesis of this compound involving Bayer AG is an interesting and promising story. In 2019, Hope Medicine issued a press release detailing impressive results for HMI-115 in a stump-tailed macaque study which was said to be “nearly doubling the number of terminal hairs after 6 months even in previously fully bald areas and showing a sustainable impact even after 2 years post treatment.” In January 2022, a press release was issued announcing that Hope had received IND approval for a phase 2 trial in androgenetic alopecia in the US. A phase 1 trial in Australia began in May 2022 for both males and females with AGA.
Status: An IND for a US Phase 2 trial was approved in 2022 and a Phase 1 trial was initiated in Australia in May 2022. The Phase 1 trial is estimated to have completed enrollment in July 2023, and is likely full completed as of October 2023. 

6. Moogene Medi – Moogene Medi is a Korean company developing topical therapeutics which are delivered through a proprietary system comprising lipid nanoparticles, microbubbles, and ultrasound. While the company initially intended to develop a CRISPR therapy for androgenetic alopecia which cut out the gene responsible for producing 5-alpha reductase (the enzyme which creates DHT), it has now switched its focus to the delivery of finasteride and dutasteride due to regulatory hurdles. The current treatment approach is called HUTERA. The CRISPR therapy for AGA is still a potential if/when a territory which would welcome it for clinical trials is found.
Points of Interest: Moogene Medi’s HUTERA treatment system delivers around 20x more of an active substance (e.g. dutasteride) to the dermis layer compared to dutasteride in a topical alcohol solution. HUTERA also showed comparable blood serum levels of dutasteride, compared to topical dutasteride in a alcohol solution, however HUTERA intends to be used around once per week which could limit side effects and create an advantage. Since HUTERA is based on approved drugs, i.e. finasteride and dutasteride, it could have a fast path to market, taking around only one year.
Status: Preparing for a clinical trial asap (~2024) in Korea.

7. Shiseido/ReplicelReplicel’s hair growth treatment, RCH-01, involves culturing a person’s own hair follicle cells and then re-injecting them back into their scalp. First, a small punch-biopsy is removed from a person’s healthy hair follicles. Then, a specific cell is dissected from the follicle and cultured in a growth medium. The cells are replicated into the millions and then injected back into the person’s scalp. There is a short video about the procedure here. Replicel has been involved in a lot of activity over the past years to further develop their RCH-01 treatment into a worldwide success. For starters, Replicel created a partnership with Shiseido, which is the fourth largest cosmetic company in the world. In May 2014 Shiseido opened a huge biotechnology facility in Japan to accelerate the launch of Replicel’s hair technology RCH-01. This endeavor coincides perfectly with Japan’s new legislation which is designed to help expedite the trial process for stem cell technologies. In other words, Japan is an ideal place to launch a new cellular-based technology and get it to market quickly. To be clear, Shiseido and Replicel are separate companies. Replicel has licensed Shiseido the rights to bring RCH-01 to the world through an expedited regulatory path in Japan. It is worth mentioning that Shiseido also has its own scientists who are working on a separate hair regeneration technique using iPS cells. A treatment using iPS cells would be a further advancement and could potentially produce an unlimited amount of hair regrowth.
Points of Interest: Shiseido trialed Replicel’s RCH-01 in Japan from mid 2016 – 2018. Since then, no results from the trial have been shared by the company which has brought about speculation on its outcome. Shiseido announced results in 2020 which were mildly underwhelming; it also launched a follow up clinical trial in 2020, this time including multiple injections of RCH-01 to get a better idea of efficacy potential. That trial is still ongoing and recruiting and will likely complete in 2023.
Status: Currently undergoing a new Shiseido trial in 2022 with multiple injections to get a more complete idea of RCH-01’s potential as a hair regrowth therapy. As of October 2022, the trial is still listed as recruiting with a total number of participants set at 36.

8. Cosmo Pharmaceuticals (Cassiopea) – Breezula is the brand name of the topical anti-androgen developed by Cassiopea for the treatment of AGA. The actual drug itself is called clascoterone and is also used to treat acne. Unlike other anti-androgens we have seen which block the body’s production of DHT, Breezula instead works by blocking DHT’s ability to bind to androgen receptors in the hair follicle. It is also claimed that Breezula reduces the skin’s production of prostaglandin D2 (PGD2), a biological compound which, in elevated levels, has been shown to inhibit hair growth. Cortexolone-17α-propionate, the active ingredient in Breezula, is also being trialed by Cassiopea to treat acne. In July 2018, Cassiopea issued a press release describing positive data midway through the phase 2 dose ranging trial. In April 2019 another press release was issued detailing the fully completed 12 month trial.
Points of Interest: Clascoterone/Breezula is a topical anti-androgen with (reportedly) no hormonal side effects. The company states that the drug does not interfere with the androgenic profile of treated patients. Cassiopea also stated the early phase 2 results Breezula produced at 6 months were comparable to oral Propecia’s results in a 12 month trial. In June 2023, a press release was issued announcing the start of a phase 3 clinical trial for Breezula in male patients. The phase 3 trial will include two 6 month phase 3 trials, whereas after the first 6 month trial, participants which are deemed as responders to the treatment will enter an additional 6 month trial to receive either more clascoterone or placebo. Full study details are listed on ClinicalTrials.gov
Status: A Phase 3 clinical trial for male AGA was initiated in June 2023 and is estimated to complete in early 2025.

9. HairClone – HairClone is a British biotechnology company seeking to rejuvenate hair through the use of cultured dermal papilla cells. The company has put together an interesting business model while also leveraging scientific innovations and a advantageous regulatory pathway. HairClone envisions patients banking a few of their hair follicles in a deep freeze storage facility and then utilizing those follicles periodically over the course of years to create cellular cocktails to be injected back into their scalp. This is an innovative approach to cellular hair growth therapy and makes the process of undergoing repeat procedures easier for patients. HairClone anticipates that their cellular therapy will rejuvenate existing hair follicles that have become weakened. The company also anticipates that cellular injections could convert DHT-susceptible follicles into DHT-resistant follicles. Key leadership for the company includes Paul Kemp PhD, Vincent Ranford PhD, and well known hair surgeons Drs. Bessam and Nilofer Farjo. A news video describing the HairClone procedure was reported in 2017.
Points of Interest: The founders of HairClone were responsible for the first company to attempt hair regeneration via cell therapy (Intercytex) in the late 2000’s. HairClone has assembled a robust scientific advisory board including well known researcher Dr. Claire Higgins. Its procedure is projected to involve only one surgery to extract ~100 hair follicles via FUE, place those follicles into cryopreservation, and use them as needed over the following years. HairClone estimates a patient may want to receive follow-up injections every 2-3 years to maintain optimum hair health. The company unveiled a crowdfunding campaign in 2018 which did not meet its goal. After the failed crowdfunding attempt, HairClone secured a few government grants to continue its development in 2020. After global delays incurred in 2020, HairClone continues to further its program into a small scale investigative operation in the UK.
Status: Undergoing preclinical research to create a GMP licensed facility/process for the purpose of expanding dermal papilla cells. As of October 2022, HairClone is still seeks to offer expanded cell treatments to practitioners in the UK ASAP, with H1 2023 as a potential.

10. Tsuji/Riken- OrganTech– Dr. Takashi Tsuji runs one of the most advanced stem cell labs in the world at the Riken Institute in Japan. In mid-2016 it was announced that Riken would be establishing a joint venture with the electronics company Kyocera and the regenerative medicine company Organ Technologies to bring Dr. Tsuji’s hair regeneration treatment to the market. In the joint venture Kyocera will be developing the cell processing devices and RIKEN and Organ Technologies will be responsible for the stem cell culturing and manipulation, the production process, and implementation of the preclinical trials. The treatment involves extracting a small number of hair follicles from a person’s donor scalp area and then isolating two specific types of cells from the follicle – papilla cells and epidermal cells from the bulge region. These cells are then cultured, expanded, and combined to create a hair follicle “germ” or “follicular primordium.” Once the hair follicle germs are ready they are transported to a facility where they can be implanted back into a person’s scalp to grow hair. Many people have speculated that this type of hair cloning technology could be a holy grail baldness cure.
Points of Interest: Tsuji has been doing hair follicle research for several years now and it’s awesome that the strategic partners are finally in place to bring his hair growth treatment to the world. Organ Technologies will develop this treatment in Japan which currently has the fastest track to market approval in the world for cellular therapies. In June 2018, RIKEN announced their lab is moving forward with animal studies for a newly refined protocol, and if successful they would subsequently initiate human trials. In early 2021 Dr. Tsuji announced a crowdfunding initiative to move his project into human trials. After an apparent setback in late 2020, the Organ Technology company has re-emerged in 2023 as “OrganTech”, and announced investment from Kobayashi Pharmaceutical Co. 
Status: The re-invigorated OrganTech company aims to enter clinical trials in 2024, although with no firm evidence for achieving that as of October 2023.

11. Stemson Therapeutics – Stemson Therapeutics is a hair multiplication company based in La Jolla, CA. The company has been founded by Dr. Alexey Terskikh who is known from his research on hair cloning at the Sandford Burnham Prebys Institute. The first iteration of Terskikh’s research in hair cloning made headlines in 2015 when he was able to grow hair on mice using human induced pluripotent stem cells which were converted into dermal papilla cells. In 2019, the Sanford Burnham Prebys Institute announced that Terskikh had created a separate company (Stemson) to further develop his hair cloning research into a commercial therapy. The company now stands as North America’s front runner in the hair cloning industry. CEO Geoff Hamilton has told the media that Stemson is hoping to begin human trials within the next few years.
Points of Interest: Stemson claims that they only need a small tissue sample from a patient, even blood, to create an unlimited supply of hair producing “folliculogenic” cells. In June 2019, Stemson announced it had received a $3 million investment from the pharmaceutical powerhouse Allergan. Stemson also claims that it will be possible in the future to create allogeneic treatments with their technology. This means a patient will not need to harvest their own cells to produce the folliculogenic cells and could simply receive injections from a compatible cell line developed by Stemson.
Status: Currently developing a hair multiplication therapy using all human cells and a biodegradable scaffold which guides the direction of hair growth through the skin. Aiming at human trials asap (~2025).

 

12. Tissuse/J. Hewitt  – TissUse’s hair multiplication technology “Smart Hair Transplant” or SHT has been licensed to the biopharmaceutical company J. Hewitt of Japan. Through this agreement J. Hewitt has rights to develop and commercialize the SHT procedure in Japan where regulations allow stem-cell based technologies to reach the market faster than anywhere else in the world. In September 2019, CEO of J. Hewitt, Jon Knight, told Follicle Thought that his company had ambitious plans to get SHT into a clinical trial quickly and “prove to the world” whether the treatment works. If successful, SHT would change the current paradigm of hair restoration. In the SHT procedure, 30 hair follicles are first extracted from the donor area of the scalp. Specific cells are isolated from the extracted follicles and then put through TissUse’s proprietary culturing technique. The company theorizes that from 30 hair follicles the SHT procedure can create 10,000 “neopapillae.” The neopapillae are hair promoting cells which are capable of growing new hair follicles and rejuvenating existing weakened hair.
Points of Interest: TissUse’s technology was developed by world-class hair follicle researchers Drs. Gerd Lindner and Roland Lauster. Their initial scientific paper on hair multiplication was published in 2011 and the technology has been continuously refined since then. If and when a clinical trial is initiated in Japan, pending success, the SHT treatment could have an abbreviated path to market due to Japan’s regenerative medicine regulations.
Status: After facing many delays due to global health conditions, J Hewitt continues to seek a manufacturing partner to embark on a landmark cell therapy clinical trial in Japan.

 

No Longer On The List:

Follica –  Follica was founded in 2007 and its science is based on creating micro-wounds in the scalp to create hair follicle generation. Since the time of Follica’s original clinical trials (which did not bring about the desired results), Follica has continued its research and development on combining novel compounds with micro-wounding to proliferate hair follicle formation. The name of Follica’s treatment platform was originally called R.A.I.N. or regeneration abrasion induced neogenesis. In 2019 the treatment was officially titled FOL-004 in the company’s press releases. FOL-004 is a two part process which consists of 1) a micro wounding therapy combined with applied compounds which takes place in the clinic, 2) followed by a treatment package to be used at home consisting of a topical formula and an application device. Follica’s website, at one time, has also shown a smart phone app to help users keep track of their at-home treatment routines.
Points of Interest: Follica’s co-founder Dr. George Cotsarelis is one of the household names in the hair follicle research world and has an array of hair growth related patents under his belt. About 10 years deep in development, Follica’s next step is to initiate a pivotal trial, which, pending results, could lead to Follica’s hair growth therapy becoming market approved shortly thereafter. The in-office portion of the FOL-004 treatment is reported to take only 5 minutes. In 2019, Follica announced positive results, a “44% improvement of non-vellus hair count”, from a clinical study with male participants.
Status: After announcing positive clinical results in 2019, the FOL-004 clinical program appears to be on hold as of October 2022. The next announcement would be the initiation of a pivotal trial for FDA approval of its drug + device combo. As that announcement does not appear to be imminent, Follica has been removed from the active list.

 

Biosplice Therapeutics (formerly Samumed) – SM04554 aka Dalosirvat is a small-molecule topical solution that activates the Wnt pathway to grow hair. In March 2016 Biosplice/Samumed presented their highly anticipated phase 2 results at the American Academy of Dermatology. The Phase 2 results got a mixed response from the online world of hair growth enthusiasts, but ultimately, the treatment did grow hair in the trial. The best responding group from the trial showed an approximate 10% overall increase in hair density. This phase 2 trial also lead to the conclusion that SM04554 does not create a “dose response” in patients who use it. This means that adding more of the drug to a patient’s biological system does not lead to increased results. Finding the “just right” dosage and application is important for this drug to work its best.
Points of Interest:
Biosplice/Samumed began by breezing their way through clinical trials and completed an important phase 2 within about two years time from their initial startup. The company has even reached the phase 3 level for its drug which is rare in the alopecia field. The phase 3 trial for SM04554 began in November 2018 and is scheduled to complete in January 2021.
Status: Biosplice has completed a Phase 3 trial for SM04554 in Turkey in January 2021. Since then, the company has taken the SM04554 program off of its website and told patients via email response that it is no longer developing the therapy internally and seeking a partner for the drug, which is an unlikely outcome.


Histogen – Histogen’s Hair Stimulating Complex (HST-001) is a cell conditioned media that is derived from neonatal cells grown under embryonic-like conditions. It is an injectable serum that is used to stimulate the growth of new hair follicles as well as existing ones in a person’s scalp. This treatment was first announced around 2008 and a lot of people are eager for it to be released on the market. HSC has shown visual evidence of its efficacy and has had great numbers in clinical trials. The treatment has been trialed on both men and women and is said to be effective at regrowing hair at the temples as well as throughout the scalp
. Compared to its initial inception, the current HSC product has been refined over the past few years to contain less cellular impurities and be a more concentrated formula of growth factors. After a long drought of news or progress, Histogen carried out a phase 1 female trial in the US in 2018.
Points of Interest: This is a treatment that has a very high appeal due to its ease of application. Theoretically, you could walk in, receive injections, and walk out. No need to harvest your own cells and come back to get them re-injected such as with other cellular based treatments. If a larger pharmaceutical company (such as Allergan) would be interested in partnering with Histogen, the HST-001 product would likely speed through clinical trials and become a highly successful product. It could be implemented in offices that offer aesthetic injectables such as botox or collagen.
Status:  Results from a Phase 1B for men were announced in February 2021 showing that HST-001 did not show a statistical significance over treatment with placebo. On June 3, 2021, Histogen announced that it is suspending the development of HST-001.

FollicumFollicum is a Swedish biotechnology company that is developing human peptides for the use of stimulating hair growth, and potentially inhibiting hair growth. The lead candidate peptide of Follicum’s pipeline is called FOL-005. In its first clinical trial the peptide was tested on the thighs of human patients and displayed an increase in hair growth in the treated areas. FOL-005 was subsequently tested in a phase 2 trial on human scalps by injection delivery. That trial showed FOL-005 was able to create an average increase of 7 hair per cm² among the trial subjects. Follicum has since developed a topical cream-like version of their peptide to make the treatment more user-friendly. In 2020, a topical version of FOL-005 will be tested on human scalps and will be a decisive moment for the potential hair growth drug.
Points of Interest: Follicum debuted a graph of FOL-005’s pre-clinical trial results on Follicle Thought, which were impressive. Follicum has been working with renowned hair researcher Ralf Paus since 2012 to further their R&D. In late 2019, Follicum announced that a topical formulation of their peptide has been completed through collaboration with Bioglan and is ready to be trialed.
Status:  A Phase 2A trial using a topical version of FOL-005 we completed in early 2021 and the results did not show positive statistical significant compared to placebo, thus, their program for hair growth has been dropped.

Rapunzel Two of the most prominent names when it comes to hair follicle research, Dr. Colin Jahoda and Dr. Angela Christiano, have teamed up to bring an effective hair loss cure to the masses. Dr. Jahoda’s latest public work has been focused on 3D dermal papilla culturing, while Dr. Christiano has been popping up frequently in news headlines for her research on JAK inhibitors and hair growth. Dr. Christiano has even recently sold her JAK IP to Aclaris Therapeutics who is carrying out trials for JAK inhibtor’s use in treating AGA and alopecia areata. Even better, these two researchers are reportedly teaming up on Christiano’s new startup “Rapunzel” to develop a treatment using cultured hair follicle cells to regenerate hair. Christiano has recently stated “we can grow rat hair like it’s no tomorrow, but we think we can do it with human hair, too.”
Points of Interest: Dr. Jahoda implanted his own hair cells into his wife’s arm and found that his cells grew hair on her arm all the way back in 1999In other words, the man is experienced in cellular hair growth research. Also, Jahoda and Christiano have both been issued a new patent related to 3D hair follicle culturing in January 2017. 
Status: The company website which never contained a pipeline or much information has now expired, a telling sign for the direction of progress.

RiverTown Therapeutics Inc. – RT1640 is composed of minoxidil, cyclosporine-A, and a novel molecule RT175. This compound was developed by the founder of RiverTown Therapeutics Inc., David Weinstein MD, PhD. In a pilot trial, 100% of the people who used the treatment had satisfactory hair growth and, reportedly, several people had significant hair regeneration. RiverTown Therapeutics debuted their fantastic hair growth results on Follicle Thought. The three agents in RT1640 act on distinct pathways of AGA and synergize to promote the growth and maintenance of hair follicles. RT1640 also reanimates the melanocytic progenitor cells which give hair its color, hence, RT1640 is said to restore pigment to some of the regenerated hair as well. Interestingly enough, RT1640 was brought to life through its founder’s personal interest in treating his own baldness. RiverTown was featured in a popular article for the New Yorker magazine in June 2018.
Points of Interest: The results for RT1640 are promising for a topical treatment. Not only does RT1640 regrow hair, it is also able to restore pigment to some of the hair it regenerates. The three agents that compose RT1640 have strong safety profiles and have all been tested in clinical trials previously.
Status: After years of unsuccessfully seeking funding for an important phase 2 trial, the company has closed its doors. 


Aclaris Therapeutics – In early 2016, Aclaris acquired the rights from Angela Christiano’s company Vixen to use JAK inhibitors to treat alopecia areata and androgenic alopecia. JAK inhibitors have shown some amazing results in alopecia areata, sometimes regrowing full heads of hair. Preclinical research has shown that JAK inhibitors may have the ability to benefit all types of hair growth. Human trials for androgenic alopecia were initiated by Aclaris in Q2 2018 and showed positive results. However, in August 2019 Aclaris announced that is was putting its JAK inhibitor alopecia programs on permanent hold due to the cost and lengthy durations of their associated clinical trials.
Points of Interest: JAK inhibitors have shown the ability to push hair follicles into the growth or “anagen” phase; this was published by Angela Christiano. The company released data in June 2019 showing positive results for treating AGA with JAK inhibitors. In order to reach the market, Aclaris’ programs for alopecia would need to be partnered with a larger pharmaceutical company who will fund the necessary remaining clinical trials.
Status: Aclaris is no longer pursuing development of their JAK drugs for AGA and AA. The only potential way forward for these programs is to partner with a larger pharmaceutical company, which is unlikely.

Allergan (from Kythera) – Setipiprant is an oral medication or pill. Specifically, Setipiprant is a prostaglandin D2 receptor 2 (PTGDR2) antagonist. Setipiprant was originally developed for medical applications aside from hair growth and has undergone clinical trials for those indications. After George Cotsarelis discovered at UPENN that Prostaglandin D2 potentially plays a major role in hair growth, Kythera began pre-clinical trials with Cotsarelis’ office to determine if PTGDR2 antagonists were worth developing as a hair growth treatment. About two years later, Kythera announced it acquired the rights from Cotsarelis to use setipiprant for hair growth. Since that time, the larger pharmaceutical company Allergan has acquired Kythera and setipiprant with it. Setipiprant is now undergoing a phase 2A clinical trial.
Points of Interest: Setipiprant has already undergone a phase 3 trial in the US. This has allowed the product to begin at phase 2 in the clinical trial process for androgenic alopecia. Since it is an oral medication it is easy to administer and comply with.
Status: After a phase 2a trial did not show significant results, the program appears to have been dropped by Allergan.

Fidia Pharma Trinov aka the “Brotzu Lotion” is a formula created by Dr. Giovanni Brotzu, a vascular surgeon from Italy. This hair growth treatment was discovered while Dr. Brotzu was testing a drug formulation to treat vascular insufficiency in patients with diabetes. It was noticed that the drug formula regrew hair on the patients’ legs during the vascular study which lead Brotzu’s team to test the formula on people’s scalps. Those tests proved worthwhile. The formula was then modified to use DGLA instead of PGE1, because DGLA would not be classified as a drug and would require much less clinical trials to be approved for hair growth. The known ingredients of this lotion include DGLA, Carnitine, S-equol, and Cationic Liposomes. The Italy based pharmaceutical company Fidia Pharma has acquired the rights to manufacture the Brotzu formula for hair and is apparently performing a clinical study with the lotion for use in people with AGA. The study has now been completed and Fidia has said the treatment should be available by the end of 2018.
Points of Interest: Fidia Pharma purchased the rights to develop this hair growth lotion after viewing its preliminary data. Dr. Brotzu has also released a compelling photo in 2016 of a young girl with alopecia areata who used the lotion and got impressive results. It was announced in September 2018 by Fidia Pharma that the formula from Dr. Brotzu would be marketed under the name “Trinov” and launched in Italy by the end of 2018.
Status: After keeping many people’s levels of interest high for several years, the formula hit the market and received less than praise from many of its users. After an underwhelming response from Trinov users it does not meet the criteria to be listed on the Ultimate Guide anymore.

422 Comments

  1. Sheila Mizrahi on November 8, 2015 at 4:10 am

    Thank you for keeping us all updated. My daughter started to loose her gorgeous red hair when she was 14 years old..She’s now 25! …… Very thin spare hair left…. Tried everything.. Including FUE and all oral medications… Trying ACELL PRP injections next month… We are still hoping for a cure!



    • Follicle Thought on November 8, 2015 at 4:57 am

      Hello Sheila,
      I very much hope that good things come for your daughter. She is lucky to have a dedicated and caring mother like you who is actively seeking a cure on her behalf. Not everyone has someone like that in their life. I know it might not sound like great consolation at the moment, but I can say confidently that your daughter will not have to go through her 30’s with the same struggle. The new technologies are coming and will be here soon. Keep the faith.

      Best Wishes,
      Joseph



    • Tar2305 on June 22, 2016 at 9:17 pm

      Do you have any update for us ?



      • Sheila Mizrahi on June 24, 2016 at 5:49 am

        She’s completed the full head prp treatment.. Doc says he sees some improvement.. We don’t see it… He says need a full year… Getting very frustrated… May be time for a hairpiece until something starts to change ????



        • poyraz on June 24, 2016 at 2:41 pm

          finastreid has unknown side effects !!!
          They enter the bloodstream through the skin , topical application is the same .
          high risk



          • bernd herrmann on December 28, 2018 at 7:21 am

            i take it since 15 years without any side effects……



        • Anthony on December 10, 2016 at 12:41 am

          I did prp. It did nothing.



          • Pablo on January 24, 2018 at 10:07 am

            yo también, gasté mucho dinero y nada… a un año ni un pelo mas



        • Priya on August 30, 2017 at 11:43 am

          Hi Sheila – any improvement? I may visit dr Prasad soon but hoping for some positive results from someone before that? Has anyone tried mesotherapy? Is it of any use? Side effects?



          • Sheila Mizrahi on September 2, 2017 at 10:16 pm

            Took a year to see improvement ; my daughter n Doctor see some. Also less hair falling out… she’s going to do a booster in a few months… go for it



    • Ben on March 14, 2017 at 5:12 am

      Hi,
      ”while Dr. Christiano has been popping up frequently in news headlines for her research on JAK inhibitors and hair growth. Dr. Christiano has even recently sold her JAK IP to Aclaris Therapeutics who is carrying out trials for JAK inhibtors use in AGA and alopecia areata”
      Is this bad news for those with alopecia totalis Dr. Christiano is one of the most active doctors in this field and it now seams she is moving to study male and female pattern baldness?



      • Follicle Thought on March 14, 2017 at 8:11 am

        Hi Ben,

        It’s actually good news. The areata research is being brought to clinical trials and Angela is continuing research to regrow hair for everyone.

        Best



      • Sheila Mizrahi on March 14, 2017 at 11:10 am

        Thanks I’d love for her to see my daughter; tried reaching out several years ago with no response.. If you’ve got a connection let me know.. She is in our neighborhood..
        Thanks
        Sheila



    • Alex on November 30, 2017 at 10:49 pm

      Hey Shiela, not sure if you’ll read this, but every time I tune in to see the updates posted on this I always come back to reading your comment. How is your daughter? Any progression?



    • ap on April 3, 2019 at 3:17 pm

      Take biotin along with probiotics containing Lactobacillus Acidophilus DDS1, Bifidobacterium Lactis, and Bifidobacterium Longum. I take 1 Biotin + 2 Probiotic along with meals (lunch and dinner). My hair stopped falling and became thicker.



    • Debbie Buckner on June 14, 2019 at 1:38 pm

      My precious 20 yr old is fast loosing hair. Contemplating PRP. Wondered if you had good results.



    • Mano Ranjan on January 26, 2020 at 12:38 am

      Do this. Take juice of small onions. Add vit E tab ( remove cap and add ingredient into juice). Add 10 drops of virgin coconut oil. Mix the juice thoroughly and apply on scalp for 3 weeks. You will get all hairs back.



      • neo on July 2, 2020 at 6:33 am

        did it work for you? be honest



    • LAXMINARAYAN JOSHI on April 7, 2022 at 10:58 pm

      HI PLEASE CONTACT ME AT JOSHI@PHARMAGENERICS.CA OR WHATSAPP 647-997-2773 I HAVE SOLUTION FOR YOUR DAUGHER HAIR LOSS



  2. poyraz on December 18, 2015 at 2:18 pm


  3. Gemma on January 18, 2016 at 6:46 pm

    This is a great compilation of hope for those of us suffering from hair loss. Thank you.

    Sheila, how did the A-cell PRP work for your daughter? Where did you go for the procedure?



  4. Sheila Mizrahi on January 18, 2016 at 9:52 pm

    We did a test patch with Dr. Prasad. We are one month out. Too early to tell . He will check her every 3 months .. If he sees improvement then we do the whole head. The procedure wasn’t bad , aside from slight pulling feeing for a few days. No hair fell out so that’s a good sign cause some females shed a bit.
    My daughter is very far advanced in hair loss and Doc says he hasn’t treated a female with so much diffuse hair loss before, hence the test patch… Will let you know… We love the Doctor He was very honest and gave slot of his time..
    Sheila Mizrahi



  5. Sheila Mizrahi on January 18, 2016 at 9:52 pm

    We did a test patch with Dr. Prasad. We are one month out. Too early to tell . He will check her every 3 months .. If he sees improvement then we do the whole head. The procedure wasn’t bad , aside from slight pulling feeing for a few days. No hair fell out so that’s a good sign cause some females shed a bit.
    My daughter is very far advanced in hair loss and Doc says he hasn’t treated a female with so much diffuse hair loss before, hence the test patch… Will let you know… We love the Doctor He was very honest and gave slot of his time..
    Sheila Mizrahi



    • dean chapman on May 3, 2017 at 4:41 am

      Hi Sheila,

      I am writing to ask if your daughter had success with Dr. Prasad’s treatment? I am looking to give it a shot…
      Hope all’s well

      -Dean



      • Sheila Mizrahi on May 3, 2017 at 12:20 pm

        Hi Dean, go for it! My daughter was very late at doing it but hairs got stronger & thicker n stopped falling out. No new hair as of yet. My other daughter also did it and she said it definitely made her hair thicker. He also gives a boost treatment within the year..



        • Mohammed on May 18, 2017 at 4:02 am

          Can you send me address



          • Sheila Mizrahi on May 18, 2017 at 11:56 am

            Dr Prasad 61 East 66th street Ny Ny



        • Denise on June 17, 2018 at 2:01 pm

          Hi Sheila,
          I am writing to know about your daughter. Can you tell us how are the results now, after almost 18 months?
          Thank you very much.



          • Sheila mizrahi on June 18, 2018 at 1:34 am

            They’ve both had stronger hair; some Re growth but not much; one of them had a baby so more hair fell out recently ; the other did a boot treatment recently



  6. M on February 5, 2016 at 12:28 pm

    Hi, I didn’t been able of reading this article full yet.
    It is being hard of translating because english is not my first language, just I would like to know one of all these treatments would renew my hair cycle and return follicles to its actual thickness.
    I mean hair regeneration, because I have enough density but my hair is too thin right now.



    • Follicle Thought on February 5, 2016 at 5:34 pm

      Hi,

      I believe Histogen or Replicel would work efficiently for your cause.

      Cheers
      Joseph



      • M on February 15, 2016 at 6:36 pm

        When would these treatments come to Europe?
        I have seen some posts about Histogen on Bernstein Medical – Center for Hair Restoration in NY.
        Also, do you think that treament would be something definitive for hair regeneration?
        I´m from Spain and here there isn´t anything yet, only some stem cells (preventive treatments).
        Thank you



        • Follicle Thought on February 15, 2016 at 7:25 pm

          Hi M,

          I’m not sure when these treatments would be available in Europe, some places in Turkey may have a treatment before other places in the world, though. Asia will probably be the first of all.

          I think Histogen has shown that it can regenerate hair follicles, it is just not clear how much it can regenerate yet. Overall, it looks like a good improvement for hair treatments.

          Thanks
          Joseph



  7. cavan on February 10, 2016 at 3:58 pm

    Dr. Angela Christiano- Histogen & Replicel,
    ( when would it be release in Asia ? & any side effect ?)



    • Follicle Thought on February 10, 2016 at 5:28 pm

      Replicel by 2018. Histogen in Asia possibly 2018. Dr. Christiano, no known release date. Of those treatments only Dr. Christiano’s may have known side effects.



  8. BaldingAt20 on February 15, 2016 at 6:03 pm

    Why no mention of Dr. Takashi Tsuji?



    • Follicle Thought on February 15, 2016 at 7:19 pm

      Hi there,
      I’m aware of Dr. Tsuji’s work and am sure it could possibly be the biggest achievement of them all, I just do not have any word on what stage he is at of bringing his technology to a treatment. To be honest there are a lot of Asian researchers who have substantial ongoing hair growth research and I bet a few of them have funding partners, etc. secured for when their technology is ready to go. These things will be announced over the next 1-2 years, I guess. Tsuji will definitely be on this list soon, perhaps when there is another update from his lab.



  9. Sureshkumar on March 10, 2016 at 1:01 pm

    Hi All

    Good to see. I am 27 years old, suffered from male baldness. I would like to go through some treatment. What could be the best treatment for Hair regrowth in India.

    Thanks,



    • Follicle Thought on March 11, 2016 at 12:46 am

      Hi Sureshkumar,

      Other than a hair transplant, the treatments are the same throughout the world. Replicel and Histogen somewhere on the planet will be the best new hair growth treatments.



      • Jennifer on September 21, 2017 at 4:32 pm

        I was wondering how people do with the laser caps. My hair has been thinning for years and really tired of depending on pieces and extensions . I have been using Aldactone and Finestride with little change and worried about side effects. PRP helped a bit but was very painful . Can I go to Japan to have some of these treatments you recommend now .



        • Follicle Thought on September 21, 2017 at 4:43 pm

          Haven’t seen anything very noteworthy from lasercaps. It is a maintenance treatment. The seemingly closest cellular treatment in Japan (Shiseido) is listed to hopefully be available in late 2018 at earliest.



    • antony on November 23, 2017 at 3:19 am

      mr suresh pls take onion and garlic juice mix with E vitamin capsule and apply in the scalp and leave for hole night and wash in the morning. do this for 6 months continues then see the result



  10. Nick on March 11, 2016 at 6:09 pm

    Hi I want to thank you for the effort you put into this thing. You have educated me a lot on the issue of hair loss and this site is great for staying up to date on the latest matters in hair loss. Quick question, I am almost 25 and am at a norwood 2.5. I have seen good results with finasteride, have gotten a adipose stem cell fat transfer from stomach to hair, and regularly do PRP. Do you think I would be safe to get a HT done to my hairline given the new treatments that are around the corner? The traditional viewpoint was to wait until you are in your 30s, but I would like to get one now. Just wondering if it was as risky to get one as it was in the past given what we know about replicel and histogen?

    Thanks for your effort!

    Nick



    • Follicle Thought on March 18, 2016 at 7:48 pm

      Hi Nick,

      Sorry for the delay in response. I don’t see the risk in getting a hair transplant in your mid 20s if it’s only going to be at your hairline. Most people have much more than enough donor capacity to fill in a hairline and more of the scalp. The new treatments being discussed today do look like they have the potential to be great adjunct treatments.

      Thanks
      Joseph



  11. Dila on March 17, 2016 at 3:33 pm

    Hi
    I am 32 now ..Norwood stage 3 ,is it worth to keep my follicle alive by finas , minoxidil& PRP,till replicell available in market or stop all this.



    • Follicle Thought on March 17, 2016 at 8:54 pm

      Hi Dila,

      Only you can make that decision. But I would say, why stop if you want to keep your hair?



  12. Sam on March 23, 2016 at 9:06 pm

    Replicel has announced the fee for their treatment will be 100,000 yen ($887)



    • Follicle Thought on March 23, 2016 at 10:51 pm

      Actually, they said it would be at least 100,000 yen. That’s important.



  13. Sheila Mizrahi on March 23, 2016 at 11:06 pm

    Ok is that price for one treatment? Do people need more than one? Where can we get it?



    • Follicle Thought on March 24, 2016 at 4:34 pm

      Hi Sheila,
      The real price is not announced yet. This news in the article is premature to be honest. It’s really not even worthwhile to discuss it at the moment. The location will be Japan, perhaps in early 2018, and I can all but guarantee it will be a bit more than 887 dollars.



  14. M on March 24, 2016 at 6:22 pm

    Hi, I´ve been looking for information about Hair Cloning.
    and definitely I feel hope again, looks like Angela Christiano research project would be the solution for my hair problem.
    Seems I´m not probably a good patient for hair transplant however I read hair clonning would works for everyone, including women.
    I’m right?
    just I need to know if this would be suitable for people with long hair.
    Thanks



    • Follicle Thought on March 24, 2016 at 10:03 pm

      Hi M,

      Hair cloning would presumably work for everyone, but I am not sure which treatment you are referring to. Long hair is not an issue for hair growth treatments.
      Histogen and Replicel are good potential treatments at the moment.



  15. M on March 25, 2016 at 1:14 pm

    Hi, I meant to the current research from Columbia and Durham University in the UK.(hair cloning)
    I asked to Doct Christophe about the possibility of using SCTransfer and he said that probably a hair transplant is not the most suitable in my case because I haven´t bald areas.
    My hair loss is diffuse.
    I know hair cloning isn´t yet available for people but I was wondering If there is already any official site expaining in which would consist, how much it would cost and If it is necesary being shaved for it.
    Also I´m a little confused about Histogen and Replicel.
    We are talking about the same process?
    Both come from diferent studies and countries.



    • Follicle Thought on March 25, 2016 at 6:02 pm

      Hi,

      I don’t believe there is a site like that yet.

      Histogen and Replicel are not the same. I’ve explained them pretty well in this post. Replicel has a video which shows the process. See above. Histogen uses baby stem cell proteins which are injected into one’s scalp.

      Histogen and Replicel are similar and will probably work together very well when combined.



  16. M on April 12, 2016 at 2:21 pm

    Have you ever heard about Regenerate Active?
    This new treatment is already available for patiens and reminds me to Replicel a little.

    Marbeclinic, Bonome, Dorsia clinic…
    http://www.regenerarcelulasmadre.com/presentacion-rigenera/
    http://marbeclinic.com/regeneracioncapilar.html
    https://www.youtube.com/watch?v=EikgOpkjWm0

    What do you think about this?

    I wrote them asking about this new treatment and they said:

    “The Rigenera technology is based on tissue mechanical disintegration, getting micro-grafts from the patient, where there is a high concentration of pluripontentes cells with a great capacity for tissue regeneration, such technology is being used for several years in various specialties within medicine, dentistry, maxillofacial, vascular, etc .. in the field of cosmetic medicine mainly has it begun to implement in stretch marks, scars, keloids, facial revitalization, vascular ulcers, burns, wound healing and the newest is alopecia.
    Casuistry moment about it but limited clinical cases shown so far are very encouraging.
    Either way is necessary to know the characteristics of each patient prior to venture a final result.”



    • Follicle Thought on April 12, 2016 at 4:27 pm

      I have not heard of it, but I cannot say one way or the other if I think it will be good. I’ve never seen a company doing an extraction from someone’s neck before and then using those cells somehow. Usually the technique is done to remove fat from someone’s stomach and then inject the cells into the scalp. I recommend asking a lot of questions and be cautious. If I could speak Spanish I could be more help.



      • M on April 12, 2016 at 9:00 pm

        Thanks for asking, I know what you mean this is a new treatment available in Spain and there are already some clinics offering this regenerative therapy.
        Obviously I had some doubts because this is the first time I heard talking about it .
        I thought on Stem Cell Transfer and alopecell, because both have a very similar process.But this one looks easier and without side effects.
        The company is called Regenera Activa.



  17. tolga on April 13, 2016 at 10:24 am

    hair cloning, hair multiplication, hair to produce stem cells.
    In all of these solutions will be a very difficult cancer risk
    Do you have any idea?



    • Follicle Thought on April 13, 2016 at 3:34 pm

      I don’t think it will be a big issue to be honest. Scientists typically follow the safest pathways.



    • Bruck on May 14, 2016 at 12:34 am

      Hi Tolga. I attended the 9th World Hair Research Congress in Miami last Nov. 2015. When asked, the researchers mentioned that with human studies and the Wnt pathway which stimulates hair follicles, they have to be very careful because the same pathway is related to squamous cell carcinoma of the skin. This probably makes human studies more involved and also more expensive to research.
      I am waiting for good medical products to go on the market also. Hope this helps.



  18. Sam on April 17, 2016 at 10:18 pm

    Hey admin, I just wanted to let you know of some possible good news about Histogen for the end of this month.. I was surfing through stuff and decided to go on histogens website.. Anyways found one of their presentation videos on YouTube from October 2014.. Oddly enough I looked through the comments and a recent comment from Brian naughton (Gail’s son) posted a comment saying, ” I’m Gail’s Son’s girlfriend. Great new things are up and coming! Don’t worry! :)” Weird that Histogen has been silent lately but updated their website and announced a presentation at the stem cell summit this month.. Was wondering what you think about this. My theory is that we might get a final clinical trial announcement or something. Why else would we see that comment after such an old video?



    • Follicle Thought on April 17, 2016 at 10:37 pm

      Thanks for sharing Sam. Yes, it’s possible that Gail might announce the clinical trial at the Boston event. We will find out this month, I believe.



  19. Ana on April 25, 2016 at 7:24 pm

    Hi, do you know one of all these treatments is the closest?
    with a definitive release date announced.
    There will be something true effective for androgenic alopecia in 2016 or in the early 2017?

    Thank you



    • Follicle Thought on April 25, 2016 at 11:25 pm

      Hi Ana,
      Replicel could potentially be the earlier cellular based treatment on the list, but it would not be available until 2018.

      There is a good chance that topical hair creams that are able to grow hair will be available to consumers before then. Even in 2016.



  20. Ana on May 14, 2016 at 9:56 pm

    Do you know when will be available Follica?



    • Follicle Thought on May 14, 2016 at 10:16 pm

      Hi Ana,

      Follica has said that their best estimate is a commercial release in 2018.



  21. Maria Landivar on May 15, 2016 at 8:12 pm

    Waiting for this procuct!



  22. josh on May 16, 2016 at 9:43 pm

    I think that a complete cure is so far at moment, but with which are gonna hit the market on this 2/4 years will solve the 80% of alopecias i think, as least a nw7 maybe could have a good enought hair for dont be a completlu bald.And after this treatments also u can do a hair transplant
    thats only my opinion, what do u think?



    • Sonia Ianni on October 16, 2022 at 11:16 am

      Oi Joshi me chamo Sonia moro no Brasil, eu também ficaria feliz se amenizasse meu problema de alopecia androgenetica, nem a cura procuro ,a anos sofro c esse problema, hoje tenho 57 anos e naturalmente os cabelos afinam ,tive uma doença chamada DENGUE, estou 90% pior agora mais do que nunca ficaria satisfeita com uma melhora!!!estou usando Bioscalin do laboratório Giulliani, fazem 3 semanas ainda é cedo p ver resultados, postarei aqui se houver alguma melhora,abraço. Obrigado



  23. josh on May 19, 2016 at 9:13 pm

    Hey, i Have a question:
    Do u know the Follica release date? I am confused about that, and about why people dont trust on a cure
    Follica can give us new follicles, and imagine combine it with replicel and Histogen, and sammued and hair tansplant, i think is crazy to be sad , a cure is close, but i am not sure about dates, i hope replicel for 2018, Histogen 2017¿?¿? and Follica? do u know something Joshep?
    thanks!



    • Follicle Thought on May 19, 2016 at 9:23 pm

      Follica has said that is all goes well with their testing they will file for approval in 2017 for a commercial release in 2018. It sounds like they have been working hard behind the scenes to make advancements in their products.



  24. Biff balby on May 22, 2016 at 4:20 am

    Any updates for Follica, Histogen, or Replicel on the horizon? I’ve used proscar for 5 years and I’m diffusing again, and have thrown rogaine foam and keratin fibers in just to maintain. But barely. I’m getting that cancer patient look, and my head is such a terrible shape I can’t shave it. Dermatch gets all over my gfs pillows and looks weird to me. Please let something come out within the next 18 months!!



    • Follicle Thought on May 22, 2016 at 3:14 pm

      Hey Biff,
      All those treatments you mentioned are looking to be around the 18+ month mark, but I really am optimistic about a few topicals that have the potential to be out before then that can maintain and possibly produce decent growth, namely Kelopesia, Brotzu lotion, and possibly others. I know the waiting isn’t always the most fun, but at least there is hope. Replicel and Histogen seem to be working hard behind the scenes to get their trials setup, it does involve some work.



  25. josh on May 29, 2016 at 3:37 pm

    Finally looks like Histogen will be released on 2018 and not 2017 🙁
    In another hand, do u know when are gonna hit the market kelopesia and Brotzu lotion?All i know is that kelopesia is gonna be realesed this year and lotion the next, but not the same to be on first months or the latest.
    thanks



    • Follicle Thought on May 29, 2016 at 4:40 pm

      I think you’re right Josh. It’s almost June and still no word of a trial launch for Histogen. As you know, predicting the launch of a product is a guessing game. A conservative guess for Kelopesia would be by the end of July and for Brotzu lotion, perhaps early Spring 2017.



      • Sheila Mizrahi on May 29, 2016 at 8:17 pm

        Can u tell us how Keliopesia is applied? Is it drops or lotion??? And does it work for female pattern baldness?



        • Follicle Thought on May 30, 2016 at 1:55 am

          Sheila,

          It appears to be a cream. Yes the inventor mentioned that it was more effective for females when tested. They are working on their manufacturing development right now, getting the product to be effective when stored at room temperature. Hopefully we hear something in July.



  26. Bruck on June 2, 2016 at 5:16 pm

    (06/02/16) We have not heard anything new from Replicel or Shiseido for six months. No news of them starting their Phase II clinical trials. Is this not a good sign, or does anyone know anything different?
    I know that Histogen and Samumed are both going strong and are determined to get a product on the market, hopefully by the end of 2018. All three companies had their top people at the 9th World Hair Research conference in Miami in Nov. 2015.
    Also, hopefully Allergan can start testing soon for their PGD2 inhibitor (Kythera’s setipiprant). Last news was in Sept. 2015 when the company filed with the FDA to start testing.



    • Follicle Thought on June 2, 2016 at 8:47 pm

      Thanks Bruck.
      My guess is that companies are fine tuning their trials before launching to get the best results they can. I remember Replicel mentioned after their first trial that they wanted to improve upon their cell storage and transportation in the future.



  27. Cliff Hanger on June 9, 2016 at 3:16 pm

    For years there have been articles on breakthroughs on hair loss only to see these so-called miracle cures fade like the summer sun. I lost all my hair over 10 years ago and have come to accept that there will be no cure for baldness in my lifetime. This so called remedy is just more b.s that will never amount to anything. This will fade like Laminin 411 another brilliant breakthrough that never saw the light of day. I do get really tired of these articles that try to give a glimmer of hope but only end up making people such as myself bitter because when it’s all said and done and the smoke clears, there is no cure for baldness. That’s the truth!



    • Follicle Thought on June 9, 2016 at 4:49 pm

      Cliff,
      Thanks for sharing. I normally don’t allow comments with negativity towards the content of the site, but I can sense that you are sincere and have been hoping for a cure for a long time. Some things you have said are right, for all intents and purposes right now on June 6, 2016 there is no “cure” for baldness.

      And in 1901 there were no airplanes after many tries (first flight was 1903). In 1965 no one made it to space before (first journey to space was in 1968). Or in 2007 no one could have imagined a device that fits in your pocket and does more than a laptop anywhere in the world (iphone 2008). But all of these things prove the that technology advances over time. The cure for hair is inevitable if people continue to pursue, and they are.

      I’m not sure what age you’re at, but I do believe there is significant upgrades to hair tech within the next few years. Whatever you decide, I wish you well friend.



  28. pjotre on June 16, 2016 at 9:43 pm

    Let’s be positive, I think the winner takes it all. Question is: is it a race over the 100 meter or over the marathon?



    • Follicle Thought on June 17, 2016 at 5:27 pm

      Based on the capabilities of the treatments listed, I think there will be room for many treatment options. They work in different ways and could presumably be combined.



  29. Nick on June 21, 2016 at 7:14 pm

    Hi, thank you so much for compiling this, it’s so informative

    My question is, are any of these treatments going to be effective for men with very advanced (Norwood 6-7) hair loss?

    I’m 22 and only just starting to thin, so I still have quite a full head of hair at this point, no major loss. However, men in my family do tend to go VERY bald, and I will likely go full Norwood 7 if I leave my hair loss unchecked. I’m currently attempting to stabilise any further loss using Propecia, and although I have only been on a few months it’s looking good, no immediate side effects and the shedding has decreased.

    I’m hoping for a breakthrough that’s going to make hair replacement much more possible for men with severe loss. It might not be an issue for me if I continue on the Propecia, but if I’m honest I don’t like the idea of being on Propecia for the long haul given the potential side-effects. I’d hope to eventually switch over to something more effective and less dicey with the long-term side-effects if the technology was developed to support it.



    • Follicle Thought on June 21, 2016 at 10:32 pm

      Hi Nick,

      Thanks for your comment and inquiry. At 22 still with quite a full head of hair and taking Finasteride, you are almost golden. I don’t see why you would even get to a NW6 or 7 at the rate you’re on. Some of these treatments, yes, will be effective for the advanced norwoods. But with a few key topical formulas set to be released within 2 years time your hair should be in good shape for a long long while. I believe there will be an option to get off the finasteride as well. The developments are coming. The ultimate guide is getting updated soon, stay tuned.



  30. Farhad on June 27, 2016 at 4:48 am

    Good day,
    I’m Farhad
    I’m a boy from Iran,
    I’m 32 years old
    I have hair loss about 14years
    My hair is sparse at the moment.
    I could control my hair loss a bit by taking medicine as following list:
    I use minoxidil 5% about 13 years, use Reigen Diet 8 years , used igrow and use 5 months Prosrin 3 tablets every day
    Before Prosrin I used Propesia about 10 years, but I don’t use Propesia right now.

    I did prp in iran 3 years ago but I didn’t work.

    I’m tired of taking medicine and I’m suffering from my hair loos.

    What do you think about stem sell, does it work in the case of me?

    Could you help me and tell me that what shall I do?
    Thank you very much in advance.



    • Follicle Thought on June 28, 2016 at 3:59 pm

      Hi Farhad,

      When new substantial treatments are made available to the public the announcement will be made on this blog. From there you can decide if you want to research what people are saying from experience about using the treatments and try the treatments if you want to.



  31. Manal Alexander on August 19, 2016 at 6:05 am

    Hello, My name is Manal I am femal from Egypt. I strayed lossing my hair since one year. I went to see doctor and said that I have alpieaca. I take minoxidil 5% for one year and 2 months, but still loading my hair. I took another treatment like prp and Mesotheraby. I had tried everything like revivogen and alpicean drugs but no used. Since one year till one I lost my hair and keeping lossing. Also, I have grey hair since I was young all my hair is grey so I used hair color without ammonia. I left my work bez of my hair and get out of my friend and stay at home. I was working as Sr. Admin.as I got a high college degree Diploma Buds. Admin. I lost my life, my friend and my work bez of my hair. No treatment is working with me. And it is very costly without no used. I spent a lot that lost all my money. Also I married and that effect my relation with my husband as I refused to go out or see people. It is very hurting but I hope that a new drugs maybe give me a hope. So pls I need to know everything about the new treatment and the price pls. I am sorry for my long email and sharing this sad feeling but I am seeking for a hope. Thank you for understanding.



  32. Alb on August 21, 2016 at 12:04 am

    I wanted to know if there is any possible date for the release of Replicel or Histogen HSC, I just started to notice that my temples were growing. I am 31 and I am in Norwood 1. I was told by the dermatologist that I had a mild form of ADA, and that if I didn’t take Minoxidil it will turn eventually into Norwood 2 or 3. Minoxidil worked really well by the 2nd month the temples are now covered again, but without the same density, I hope I have more density in the next 10 month, since my dermatologist told me that this effect will last about one year, and then it will only help me by loosing my hair slower. The problem is that facial hair in my forehead has grown, and I had to taked them out with a depilation device. Its not that I have become a wolf but you can notice it. I wish there was an option that did not involved those side effects.
    Do you think this new treatments can work for this kind of Alopecia.

    Thanks.



    • Follicle Thought on August 21, 2016 at 2:34 am

      I think that these treatments will very likely grow hair in the temples, and hopefully only exactly where we want it.

      Thanks,
      Joseph



  33. Balding on August 26, 2016 at 2:49 pm

    Hey man, I’m 19 right now and it looks like my hair is getting thinner, my question is should I wait for these treatments or get on fin right now? Thanks.



    • Nick on August 26, 2016 at 4:35 pm

      I’m not as big of a expert as some of the people on here especially not like the admin. But I am 25 and have been on fin for just over a year. I have not noticed any side effects when it comes to my package. I think my hair has gotten better since I’ve used it, but it’s always tough to tell tbh. I still see hair come out in the shower a few strands but that’s normal. I would get on it,but only use it every other day like I do. 1.25 mg of fin every other day is my regime. Get on nizoral shampoo as well. Watch your package. If you see anything drastic then stop using it. If you get on now, you should be fine by the time these new treatments come around.



  34. sam on August 29, 2016 at 1:34 pm

    Hi Nick,
    Thanks for d reply. Can u plz provide detils of fin like, what is d fulll name of fin and is it availavle in india?
    How it should be taken, like every other day in night? Did u find ur hair come back when u used it? How many days it took for u to see d results?
    Thanks



    • Nick on August 30, 2016 at 4:27 pm

      The drug is called finasteride. I don’t know if they have it in India. I take it every other night, sometimes I forget and take it every 3 nights. It’s not going to regrow hair that is already gone. But it’s thickened what hair I had left and I hope halted the process of further recession although I can never say for sure. But it’s definitely helped me.



  35. Razan on October 17, 2016 at 7:06 am

    Hi there,
    I’ m in my 50’s and have lost my hair in a big area at around 20 years ago. I would like to know that when such treatments as “RCH-01” or “Histogen” would successfully enter into the market, will they work for me or not?
    I think that it might not affect on my head cause the lost folicles are no more existing in my scalp.
    Thanks and regards



    • Follicle Thought on October 17, 2016 at 10:33 pm

      Hi Razan,

      Thanks for visiting. At this point no one can really answer that question. Time will tell when more trial results have been presented by those companies. I believe I’ve heard both companies remark “It’s possible” when asked a similar question as the one you did.

      Stay hopeful
      Joseph



  36. Vijay kumar on October 17, 2016 at 5:56 pm

    I want to grow new hair .i search many website for this perpose but i surprised to khow that we have not discovered any injection for it. Or any medical treatment which is cheap or suitable for everyone. I have heard that one man transplanted his liver and some days later he had new hair on his bald. It means it is possible. Please scincetists dicover injection for grow new hair on hair. We can reach moon but why can’t we do this?



    • Follicle Thought on October 17, 2016 at 10:34 pm

      There are several companies on this list creating injections for hair growth Vijay. Stay hopeful.



  37. Headdy on October 23, 2016 at 9:57 pm

    Great guide!!!
    I like this list so much – makes a lot of order.

    Please keep updating 🙂 Super!

    Thanks a lot.



  38. Jackie King on November 27, 2016 at 6:37 am

    Thank you for creating this website. While I’ve read a bit about some of this research, this is the only site I’ve found that has such a comprehensive up-to-date list of treatments being developed for hair loss.
    I’ve had lichen planopilaris for a number of years resulting in areas of scarring where the follicles have been completely destroyed.
    I’ve been advised that because of the scarring in some of those places, transplants won’t take due to an inadequate blood supply. This is where the scarring is more severe. However, some of the spots seem to have hair loss with either no or minimal cellular damage to the scalp and underlying vascular system. Most of the areas have reached the “end stage” meaning they are no longer active, although I’ve noticed new spots will show up every few years if I don’t consistently take Plaquenil.

    If I may ask, would any of these treatments work for someone with my condition? Specifically, could any of them also stimulate the growth of a new blood supply where the follicle growing cells are injected?



  39. Lance on November 27, 2016 at 8:46 pm

    A great summary article of the many companies/partnerships working hard on better, more sustainable hair loss treatments. With this many different methods being explored and some of the top players showing success, it makes it a lot easier to stay hopeful for what happens in the next 5-10 years. The L’Oreal / Poietis partnership to develop bioprinting of hair follicles might be worth watching as well.



  40. George on November 29, 2016 at 8:35 am

    Thanks for the summary. Since most of these seem to regrow hair, would the user need to stay on propecia or just lose them again. For replicel, for example, do you go once every few months?

    Would any of these functionally replace propecia? Infinite donor hair wouldn’t require the drug, correct?

    Basically, do any of these offer a non propecia solution in the next 5 years?



    • Follicle Thought on November 29, 2016 at 4:48 pm

      Propecia would be a choice when using a treatment such as Replicel. Brotzu lotion may have a similar method of action.



  41. Anwar on December 14, 2016 at 10:38 am

    Dear Admin

    My son is 18 1/2 Year and experiencing diffuse thinning and Hairline receding
    Can he start finasteride safely to keep his hair until the new treatments are launched



    • Follicle Thought on December 14, 2016 at 3:58 pm

      Anwar,
      Thanks for visiting. A doctor is your best resource to answer this question. Best of luck to your son.



  42. rod on December 19, 2016 at 12:21 am

    I meant to ask “Can I ask why kelopesia is not on this LIST.”



    • Follicle Thought on December 19, 2016 at 5:18 pm

      Sure, Rod. There was a lot of uncertainty about Kelopesia over the last several months but now is confirmed to be released again by Spring. It will be on the list shortly.



  43. mat on December 25, 2016 at 2:51 pm

    THANKX



  44. Prasanth on December 31, 2016 at 10:41 am

    I had done 3 prp sittings…I am using sawbio tablets…. initially I have good hair only 20% lost .after minoxidil usage I have lost more… And I got jaundice during taking biotin…. suddenly shedding increased…I don’t know whtat to do…just shaved my head and stopped using all…..I am not going to do risky with my health…using propecia also waste of processes… after stopping minoxidil and propecia what you get will be lost…bonus side effects… being developed scientist can’t do anything…. simply plantation is also not a fullfill average man..but plantation also not complete successfull they will shed away…grow up scientist think about people not money….



  45. Tom on December 31, 2016 at 12:47 pm

    This was a great place to find some information about the current status of future developments. Thank you for investing your time and effort into putting all this information in one place.

    I myself have been taking minoxidil and fin for several years, with some results, at the very least it’s drastically slowed down my hair loss. I recently got a LLT helmet, but it’s only been 5 months, and my friend whose had great success with that, said he didn’t see real results for a year (mind you we have different models, so who knows if it will work) . Hair loss game is one of patience I suppose. I’ve thought about PRP but I have come to cast doubts of its effectiveness. Hopefully something new is release in 2017, if not I’ll do alright till 2018 I suppose. Look forward to seeing new updates!!



    • Follicle Thought on December 31, 2016 at 9:22 pm

      Thanks for your support!



  46. Ken on January 7, 2017 at 1:55 am

    Everyone is looking forward to RepliCel and I understand why but here is my issue. I have frontal scarring alopecia and the rest of my hair overall is thin. I use a blow dryer with the comb attachment everyday to get body/lift. I’m a man and its tiresome. When your hair is thinning there are common activities you can’t do comfortably like Swimming, working out, bike riding, hiking etc. Anything that involves humidity or sweat and I mean anything. If I go to work on a hot day or simply work up an internal sweat walking to the train station (any weather) it has an effect on my hair. I know how women feel when they say humidity kills their hair.

    Anyhow, enough of my sob story and to the point. What happens in my situation when the donor area is not bald but those follicles are weak?



    • Follicle Thought on January 9, 2017 at 3:14 pm

      Ken, I wish you well.

      I’m not sure of the answer to your question. But my question for this situation would be: if the follicles from a weak donor produced hair, and those new hairs eventually got weak and you had to do the process again to restore more follicles, would that work for you? There will be cosmetic products this year that improve hair strength.



      • Ken on January 10, 2017 at 11:33 pm

        Im interested in Replicel because I want to fix my hairline. The scarring has caused damage, thinning and balding in that area. If it works, I would be open to doing the procedure more than once but I wonder how effective that procedure would be if the donor area is weak.



  47. richierich on January 15, 2017 at 2:47 am

    HI, just wondering if your aware of the status of histogen? Seems the closest to market but its gone very quiet.

    Also would you need to be taking fin for it to work? Or could injections in areas not yet lost help it be used as a maintenance option.

    Shame about brotzu being delayed!



    • Follicle Thought on January 16, 2017 at 4:41 pm

      Hi Rich,

      No updates on Histogen at the moment. I’ve never heard them mention that you would need to take Fin for it to work. Histogen believes it can be used as a maintenance option.

      Thanks



  48. Reena on January 16, 2017 at 12:28 pm

    Hi there,

    Thanks for this blog. I’m a 30 year old woman and I’ve been losing hair for the past three years. The hair loss seemed to start when I moved to London from Melbourne. I believe that the transition from soft water to hard water may have had something to do with this.

    I saw a dermatologist today and she believes that I have genetic female pattern hair loss. I am having difficulty understanding how this is possible given my relatively young age (I hear it’s more common in post-menopausal women) and the fact that hair loss doesn’t run in my family. She prescribed me minoxidil and spiro tablets.

    Can you advise of any alternative treatments that could help me? Could my dorm have been wrong? I don’t know where to turn. Any advice would be greatly appreciated.



  49. Mary on January 20, 2017 at 10:44 am

    Hi,

    I am a female 40 years old, my hair is thinning all over the scalp and getting a less density in the frot top. I´ve tried vitamins, mesoherapy, PRP injections but no big changes. I’m stll looking for a solution and I believe celular teraphy with stem cels or germ folicles could be the one.

    Any news so far?



    • Follicle Thought on January 20, 2017 at 12:41 pm

      Thanks for visiting Mary. There is a news section of this site with the latest updates, whenever any promising treatment becomes available you will see it mentioned there. Best Wishes



  50. Sonia on January 27, 2017 at 12:12 am

    Joseph,

    physicians that specialize in hair loss are hard to come by; do you know a fantastic hair loss specialist for women in CA, AZ, or NV? If not in these states, who do you recommend?

    Thanks for your website and help



  51. Biff Bigsby on January 29, 2017 at 2:18 pm

    Finally went to a top HT director in NYC and he said I’m not a great candidate presently. But, he told me to consider Scalp Micro-pigmentation between my existing hair to add the illusion of density. Anyone here try this? All I see are totally bald dudes adding “scruff” to their shaved heads, not people with slightly diffuse, longer hair.

    What this doc told me was like a Toppik solution, but without actual fibers. I’d never considered it. Have a consultation next week.

    Ideally, this could tide me over for a couple years until I need the transplant, get Kelopesia, Histogen injections. But, if it went bad, I could have horrible looking tats on my skull. Anyways, any experience would be helpful. Also, really appreciate this site. Thanks.



    • Follicle Thought on January 29, 2017 at 4:07 pm

      My first thought is, have you tried Caboki or Dermatch before? I’m a big fan of utilizing temporary solutions before permanent.



    • Ken on February 2, 2017 at 11:05 am

      Hi Biff, I’m curious as to why you are not a good candidate. I’m not doubting what the doctor told you. I’m just looking for as much info as possible. If I was a little more inquisitive in the past, I may have prevented what I’m dealing with now.

      When I went to the doctor he told me I was not a good candidate for three reasons. First, he mentioned something about my pores being unusually spread apart. Second, he said I keep my hair very low in the donor area so the scar would show in part because of the pores being spread apart and partially because I keep my hair low. Last, but certainly not least I have frontal scarring alopecia which may be the worst because the follicle is replaced with scared tissue. If I were to do the surgery there is a possibility the hair would not grow where the scarring occurred. I would have to be at the “burn out” stage of the scarring to have a better chance of growth and I stress the word chance.

      So I’m just curious as to what the doctor told you specifically about not being a good donor.



      • Follicle Thought on February 2, 2017 at 2:58 pm

        Just as an aside, you’re aware of FUE correct?



        • Ken on February 4, 2017 at 6:07 pm

          I am. We discussed both options but I was primarily interested in the FUE procedure. I still have the paperwork with the prices he quoted me on. I went to him a second time to follow up on the discussion but something didn’t feel right the second time around. It didn’t seem as if he was that interested in taking me on. I felt like I was wasting his time. Again, I wasn’t in a rush to do anything because I have to be sure my scarring has burnt out. I am certain when he mentioned the issue about the length of my hair he was referring to the FUE procedure.



  52. Joe on January 31, 2017 at 3:18 pm

    When are permanent treatments coming? I am very desperate.



    • Follicle Thought on February 1, 2017 at 12:27 am

      Hi Joe,

      The statuses are listed with each individual treatment. Hope this helps. Wish you the best.



  53. Shanthi George on February 2, 2017 at 4:34 am

    I am 34…i have two daugters ..with gods grace they have hair…i lost my hair when i was 4 month…due to side effect of pressure tabelts which she consumed at 5 month of her pregnacy…my present hair is very thin and short..is there any possible treatment …have tried many medicine. ..please reply if there is a hope…it has been years we ar
    e searching for a way



    • Follicle Thought on February 2, 2017 at 9:39 am

      Hi Shanti,

      Any of these treatments which are in development may help. Please check the statuses of the treatments and the News section of this site for updates. Best wishes

      Joseph



  54. Mark Li on February 4, 2017 at 9:44 pm

    Hi Joseph.

    I am from China and not good at English.I am 23 and lost my forehead hair in the past 2 years, the hair on my head is also thin .

    Including me, a lot of people are looking forward to Shiseido/Replicel .We believe that new technology about hair follicle cells may be more effective while drugs can’t solve severe problems .However, now i am not optimistic personally.

    For one thing, what are reintroduced is just dsc cell, so it can’t produce permanant new hair follicle . So i guess that the effect will be bad if many hair follicles are dead.It only works when someone’s baldness is wild.

    For another, we know that replicel has delayed trial2 for several times and several years.Apparently progress is not smooth.

    So l wonder if a permanent treatment can appear in the future 5 to 10years.This is my thought, what ‘s about Follicle Thought ‘s thought?
    Thank you for your hard work.



    • Follicle Thought on February 5, 2017 at 9:38 am

      Hi Mark,
      Replicel’s progress is related to having the funds to continue. My thoughts are that we have many treatments on the Ultimate Guide list. An attitude of gratitude and optimism go a long way. Lots of times in life, you get what you expect.

      Cheers



      • Francesco on February 12, 2017 at 7:18 pm

        Ciao..quale di questi trattamenti può essere utile a ridensificare una donor diradata dopo una fue?io credo trattamento dott tsuji..fiose anche histogen..sarei grato di una risposta..



        • Follicle Thought on February 13, 2017 at 11:15 am

          Hi Francesco,
          I believe Replicel, Histogen, RiverTown, Tsuji, and even Follica could add density to a donor scalp area.



    • DBW on February 12, 2017 at 5:03 pm

      dude, histogen’s planning things in China with PineWorld and you are crying! You may be among those lucky guys who would be enjoying these new treatments in the comforts of your homeland while others would be paying expensive bills for their long boring flights.

      Anyway, there’s Tsuji backed up by a huge financial support from KYOCERA and RIKEN (which even has access to governmental funds).
      All they need to solve is an inductive problem.

      So sit tight, wait and watch



  55. Lisa on February 13, 2017 at 8:03 pm

    Can anyone provide me with information if any of these treatments could be used for purely cosmetic reasons? I’m female and have always had thinner hair but not balding, I would love to one day have thicker and more dense head of hair.

    Thanks for any info



  56. Matt on February 14, 2017 at 1:13 am

    Joseph,

    You have indicated that histogen potentially could hit market by 2017.. This would be great however, other credible sources say 2018 and that seems to be complacent across the board. Where do you see that 2017 is the target..? Thank you !



    • Follicle Thought on February 14, 2017 at 9:42 am

      Hi Matt,

      I mentioned it was their goal/plan to be out in Mexico in 2017, which it absolutely was. And in the 2017 look ahead post also pointed that the 2017 target is looking less likely now. I would agree that 2018 is much more likely now than 2017, but there hasn’t been any more official updates.

      Thanks



      • Francesco on February 19, 2017 at 12:03 pm

        Ciao..volevo sapere se le cellule autologhe con replicel che vengono iniettate sul cuoio capelluto, sono in grado di generare nuovi follicoli piliferi si o no?perchè se non sono in grado di produrre un nuovo follicolo come possono densificare la zona donatrice diradata dopo un prelievo con tecnica fue?quale sarebbe la miglior soluzione per ridensificarla? Mi hai rispisgo histogen Tsuji river twon follica..quale tecnica di queste produce nuovi follicoli che possono essere introdotti in zona donatrice diradata da intervento fue?



        • Follicle Thought on February 19, 2017 at 12:12 pm

          Most of us do not know for sure. The companies say their treatments have the possibility to generate new follicles. Replicel has said this, and Follica has said this. Tsuji will definitely produce new follicles. The other treatments I mentioned before have a possibility.



  57. ZZ on February 22, 2017 at 5:39 pm

    Hi,

    Can I ask why should we wait for Replicel instead of going ahead with hair transplant / FUE? Isn’t that a better option and more permanent?

    Thanks!



    • Nick on February 22, 2017 at 7:07 pm

      With a HT, you are limited to the amount of donor hair you have available. Also, transplants don’t stop further progression of hairloss. No one is saying wait for Replicel, just be aware of the risks available with getting a HT done. My hairloss is very minimal because I got on propecia early. If you are under 45, don’t consider getting a HT without being on propecia/finasteride.



    • Follicle Thought on February 22, 2017 at 7:46 pm

      There are also people who would not recommend the finasteride and would look to using the newer treatments with a FUE. Only you will know what’s best for you.



  58. Giuseppe on March 2, 2017 at 2:09 am

    Hi there,
    Follicum Stimulation of hair growth patent has been approved in Europe. What this mean? Is a product available?



    • Follicle Thought on March 2, 2017 at 10:13 am

      Hi Giuseppe,

      The product is not available. What it means is that Follicum has been granted a copyright for their peptide in Europe.



  59. anoos madinaguda on March 4, 2017 at 12:56 am

    Good information…



  60. Vinod on March 6, 2017 at 12:59 am

    Hello,

    Any update on Clinical trial which is happening on RCH-01 in Germany and Austria? any positive results?



  61. Eneas on March 14, 2017 at 5:10 pm

    Are any of these products available for use? Thank you.



    • Follicle Thought on March 14, 2017 at 7:42 pm

      Not yet, the status/release dates are with each treatment.



  62. Matt on March 15, 2017 at 11:00 am

    Joseph,

    This site is great! Bery organized and concise on the current treatments and timelines. Question for you, do you know why Replicel’s own phase II trial never took flight? I believe I heard this was due to a lack of funding however, Im not sure if this was just speculation.



    • Follicle Thought on March 15, 2017 at 6:02 pm

      Not sure, Matt.



      • Elberton fernandes da silva Fernandes on March 16, 2017 at 4:54 pm

        Boa tarde estou na prepectativa da cura para calvice



      • TBone on March 16, 2017 at 10:19 pm

        Hi is there any news on:
        -Follicum as of today?
        -Kelopesia as of today?
        -Follica as of today?
        Please & thank you.



  63. Mujeeb Anwar on March 25, 2017 at 3:30 am

    Can hair cloaning is useful for scarring alopecia …..?…



  64. bikram on April 5, 2017 at 10:52 am

    hello
    you are doing great job bro, by updating about recent hair treatment and their upcoming process,but as if now i am really willing to hear about kelopesia update. when will it be available or it will not.it’s just can go to vain.



  65. Px on April 7, 2017 at 9:32 am

    what happened to kelopsia?



  66. Will on April 13, 2017 at 1:17 pm

    willing to be apart of clinical trials and looking for updates.



  67. SM on April 26, 2017 at 9:44 am

    great site



  68. Sonia on April 26, 2017 at 2:16 pm

    Went through the April 2017 updates, looks like nothing on the market for 2017 right ?



  69. Matt on May 1, 2017 at 3:18 pm

    Joseph,

    Is there an update on follicum’s trial that was completed in January? I know above it states results are to be released in early 2017. Have they released it?



    • Follicle Thought on May 1, 2017 at 5:08 pm

      My latest article is a Follicum update. If you mean more detailed results, I don’t think they have been released yet.



  70. Matt on May 2, 2017 at 4:48 pm

    Joseph,

    It seems to me that rivertown would only work for AA and not androgenetic. Cyclo is a anti inflammatory. So not sure how well this would work for those of us missing cells. Its not as if this is adding any new material. Would you be able to ask their CEO what the actual regeneration mechanism is in their compound? If you dont know already that is.



    • Follicle Thought on May 2, 2017 at 5:00 pm

      I can say with confidence that RT1640 is intended foremost for androgenic. If you peruse the RT site you can read about why CSA is in the formula, it has to do with gene expression. CSA allows the signal for cells to continue making hair go uninterrupted, whereas it normally would rest.



  71. gaby on May 3, 2017 at 12:54 pm

    I am from the UK. I am a 21 year old girl, i lost all of my hair 4 years ago due to alopecia. I am getting desperate, its destroyed me as a person. Steroids worked for me but i was not allowed to continue on them for long. NHS has no treatment for me. I have tried minoxidil and lotions. I have no other option. I need Ruxolitinib or Tofacitinib. Anyone who can help me get access to these drugs or involved in trials, i will be so grateful. Im desperate, please help me. I cannot continue any longer like this



    • Follicle Thought on May 3, 2017 at 4:02 pm

      Gaby, your best bet is to speak to a dermatologist that is local to you. Hope this helps.



    • Seker on February 13, 2018 at 3:59 pm

      Dear Gaby,

      My sister has the same and I know how hard it is. But, please be reminded that a lot of people have it and life goes on with or without hair.

      I hope one day AA treatment will come true until then please make peace with yourself and this condition.

      Hugs



    • Ben on February 13, 2018 at 4:52 pm

      Hi Gaby, Get a dermatologist to perscribe Methotrexate for you, you need bloods etc but it works for some and takes a long time 3months +. Also some feel tired sick some dont might be worth a try.
      Ben



  72. Matt on May 4, 2017 at 11:04 am

    Joseph,

    Love this guide. Will you be updating it for May? Thanks



  73. Eric on May 7, 2017 at 1:24 am

    I’ve been Norwood 6 bald for almost 20 years, since my mid 50s. I had nearly a full head of hair until I started to bald in my early 50s. What surprised me even more than how fast I went bald was how much my wife loved it. She begged me to just let nature have its way. Reluctantly, I did and surprisingly, it turns out that I love being bald. It was a lot of fun watching my hairline rapidly recede and simultaneously a large bald spot develop in back. It took less than two years for my hairline to retreat and meet up with my expanding bald spot. I went bald in less than two years. Is that normal?
    I’ve never regretted letting myself go bald. It’s too late for me to change my mind anyway, but it is not too late for my two sons, who most likely will follow in my footsteps. They need to hear all the options available to stop balding, should they decide they do not want to go bald. So I will email a link to this site to them. I could have used the information on this site 25 years ago. As I recall, back then the only option was hair transplants, which I could not afford at the time. Nor did I want to endure the discomfort or pain. The only downside is my head gets cold in winter and I risk painful sunburn on top of my head in summer. So I wear a hat outdoors, but not to hide my bald head. After all, male pattern baldness is nothing to be ashamed of, especially at my age.



  74. Emma on May 7, 2017 at 3:08 am

    Hello
    My name is Emma and i have been experiencing female pattern hairloss since i was 16, im now 33. It started for me when i went through puberty. My mum has it and my grandma had it.
    My hair is now 1/5th of what it was and i have significant trouble styling it. Ive kept my hair loss a secret from my husband however im getting to a point where i need to tell him. Im so ashamed. I cant tell you thw distress it causes me daily.
    Ive tried everything (in secret).
    All these trials etc sound promising, however i live in Australia. Is there anything being rolled out or trailed in Australia?
    Thankyou ????



  75. Matt on May 8, 2017 at 6:53 pm

    Joseph,

    Is there a reason you havent included hairclone on this ?



    • Follicle Thought on May 8, 2017 at 8:35 pm

      Nope, no reason. Typically the treatments on this list have been tested in humans before with the exception of Tsuji which is just an extremely well respected lab. HairClone should be on the list shortly.



  76. bald dude on May 14, 2017 at 1:13 pm

    Hi there guys does any of you knows if Reboost (turkish cream ) is any good…? I’ve been in contact with a guy from Turkey and he sent me some pictures with before and after…and to be honest it looks promising, what you think guys?



    • Follicle Thought on May 14, 2017 at 1:28 pm

      I believe soon there will be readers who start to use the product. I imagine it will be 1-3 weeks before we begin to hear about user experiences.



  77. Sheila Mizrahi on May 14, 2017 at 3:37 pm

    They just opened a website.. I believe they are selling the product if you email them. I just did.. will let you know soon.



    • bald dude on June 9, 2017 at 4:12 am

      Hi Shelia, any news about that cream, did you get that cream and have you been useing it?
      Another thing what’s the name of that site?
      Thank you.



      • Sheila Mizrahi on June 12, 2017 at 2:14 am

        Can you please remind me which cream/website I was talking about.. I’m constantly searching



      • Sheila Mizrahi on June 12, 2017 at 2:34 am

        Oh yes it was for ReBoost can be ordered from Yeditepe University email is :ReBoost.com.tr
        They never responded to my email but here’s a number; +90(216)4697777
        Let me know if you get through/ I will try again as well… good luck!



  78. Lila on May 15, 2017 at 8:06 am

    Hi Admin,

    I’m so deeply grateful to you for this blog! My hair has been thinning rapidly for years even though it does not yet look like female pattern baldness. But it’s following a similar trajectory to my grandmum and mum, where our hair went from thick and wavy, to sparse and curly and doesnt grow longer, and there is just very little hair. The dermatologist is not sure why this is happening either, saying it could be lack of B12, or just stress and recommended PRP. I’ve been told by another that I have follicle minituarization and that it is irreversible. is this true? I also have daily hair fall.

    Does PRP help in stopping hair loss and hair regrowth?
    Which of the above treatments would make most sense for me to get healthy follicles again and regrow my hair?
    I also came across Harklinikken in Denmark. Is this legit? Has anyone had any experience with this?

    Thank you so much!! I wish us all abundant hair miracles 🙂



    • Gen Adams on May 18, 2017 at 10:51 am

      Hi Lila,
      I’m 49 and have hereditary female pattern baldness which is at the stage where it is quite worrisome for me. The follicular minituarization has become greater this past year and I don’t feel I can hold off for new advances much longer.

      I’ve been under a fair amount of stress for several years and recently my B12 level was low so perhaps this has accelerated my hair loss. I have been to see two well respected East Coast doctors who have not been much help. I tried Minoxidil with no great results. Like you, I am searching for something that will provide good results before it’s too late. I am considering PRP and am interested in ReBoost but need to read more about it to understand how it works and if it can be of help in my situation. I had not heard of Harklinikken but have read a little about it after your post. It sounds legit but I wonder why it hasn’t been more talked about in these circles. Joseph, have you researched Harklinikken?

      I’m also interested to see if any women on this post have creative hair stylists who work with thinning hair that they would recommend. I am fortunate to travel often so I am open to places in the US and the UK.

      Like so many who visit this site, I am grateful to Joseph for putting together such a thoroughly balanced web destination that provides information and hope to all of us in this situation.



      • Follicle Thought on May 18, 2017 at 11:38 am

        Don’t know much about it actually, Gen.

        Thanks for the kind words.



  79. Anna on May 21, 2017 at 2:40 am

    I am a 32 year old woman who used to have the thickest hair of anyone I knew, and now because of the AGA I had starting in my teens, it’s among the thinnest of anyone’s hair I know. This has made me so self conscious and I have been holding out hope for these treatments but it seems like they keep getting delayed and delayed and delayed again. I am worried that by the time they finally come out, I won’t be able to benefit from them or I’ll be an old lady and have lost my looks anyway so it won’t matter. I would really like to have my thick, beautiful hair back while I’m still relatively young. Is there any hope of that happening?



  80. steve on May 23, 2017 at 2:32 am

    The ReBoost pictures posted with the article don’t have a time span noted with them, so is it weeks or months?



    • Follicle Thought on May 23, 2017 at 6:08 pm

      The translated Turkish article mentions time span for some of the subjects I believe.



  81. Matt on June 15, 2017 at 3:29 pm

    @Follicle Thought, love this organized view of updates. Will you be updating this for June? I know some release dates have been pushed back, for instance Follica’s delay.



  82. Mike on June 18, 2017 at 2:19 am

    Any updates for May or June, Joseph ? Will you be updating this list? Great list!



  83. Karen on June 18, 2017 at 1:28 pm

    Hi I have worn a baseball cap for over 5 years and rarely go anywhere I can’t. I go to games late that you have to take off your cap. I miss out swimming and rides with my kids. Getting my license renewed is stressful. I feel ugly. Been living like this for 15 years.went into debt still no hair.



    • Lewis on June 22, 2017 at 1:32 pm

      Hi Karen, I can rely on what you’re saying even though I’m a man, for us it’s not unusual to lose hair, I wish they find something in the near future, hold on my friend and take care 🙂



      • seba on June 23, 2017 at 2:56 pm

        Hi Karen. Sorry to hear that. I think all the people with alopecia feel the same. I started to lose my hair in 2000 and in 2004 I had hair transplant with FUSS. Of course I go on losing hair and I have the fucking scar so I can`t shave my head. I understand you because I feel the same. My alopecia made me a sad person and with no social life.



    • Ken on June 23, 2017 at 8:48 pm

      Karen, many of us know what you are dealing with to some degree and it’s tough. I can’t even see myself dating anyone at this point. I spend anywhere from 30 to 60 minutes fixing my hair every morning and it still does not look great when I’m done. Now that is is summer and humid, it’s almost pointless. Im a guy and I could shave it all which would be so convenient. At what cost though? I may loose what little self esteem I have and that ain’t much. Anyway, I just you want you to know you are not alone. I believe it’s tougher for a woman but we still have an understanding of what u are going through and how it effects all aspects of your life.



  84. David on June 28, 2017 at 5:05 am

    Hey Follicle Thought.

    Been following Shiseido and Replicel for a few years now.
    Would love to know your thoughts about their partnership?
    Also if you believe 3rd quarter 2018 is realistic or enough time to release their hair regeneration technique commercially in Japan?
    Hope to hear back from you soon.
    Cheers



    • Follicle Thought on July 4, 2017 at 11:34 pm

      The trial is going on right now and depending how everything goes, I believe like they have stated, the treatment could be available in 2018. It depends on how smoothly things go I suppose.



  85. shpak on July 10, 2017 at 11:27 am

    Good morning. I am new to this post. I found it while doing a search for hair cloning. I too am struggling with hair loss. I noticed the other day that my hair loss has gotten significantly worse. To make matters worse, I have already had 3 transplants and the lines are starting to appear. I’ve been following hair cloning for some time now and the dates are always being pushed back. Is there any solid date as to when it should become available. Are Histogen and Replicel reliable? Will it leave a scar and what is a ball park cost for the procedures. Thank you so much in advance.



  86. Jordan on July 12, 2017 at 10:53 am

    So basically, We have to wait somewhat around a full year from now in order to start seeing functional treatments, probably even some more since due dates tend to get delayed most of the time.



    • Follicle Thought on July 12, 2017 at 12:29 pm

      Keeping the fingers crossed ?



  87. Ashok on July 12, 2017 at 10:28 pm

    I wish some day full treatment come and I see the hair of my young days



  88. Naman on July 22, 2017 at 10:04 am

    What about the onion juice? isn’t it a best solution for regrowing hair?



  89. John Smith on July 27, 2017 at 5:27 am

    Nowadays, PRP + ACell hair restoration treatment is one of the beneficial and effective treatment for hair loss.



    • Billy on August 3, 2017 at 9:37 pm

      Im sorry to say, but i believe those treatments are the most effective ways to lose money.



  90. vas on August 1, 2017 at 9:29 am

    last week follica added to its team 5 dermatologist. all of them, specialized in laser treatments. it feels like they are moving forward, entering the phase of training the doctors who will deliver the “RAIN”.
    It is going to happen, i just dont know when.



  91. Ben on August 1, 2017 at 11:58 am

    Just wondering did anyone hear of a drug call sulfasalazine being used for alopecia areata and also its success rate.



  92. Alejandro on August 1, 2017 at 8:47 pm

    I lost 60% of my hair 15 years ago, when that happened I felt bad. But not now. Life is more than just hair. What I can tell you is that your life needs to continue. Take the shaver and enjoy life. Does not matter if you are man or woman. The reality is that you are losing the best years of your life due to a problem that may not have a cure during the following 10 – 20 years.



    • Follicle Thought on August 1, 2017 at 9:10 pm

      I appreciate the sentiment and certainly encourage people to live their best lives.

      However, a cure is virtually guaranteed within the next 10 years, if not 5.



  93. Liz on August 7, 2017 at 4:23 am

    I had 2 sessions of PRP and it actually accelerated my hair loss. I had no results from it what so ever. It was a total waste of money and made my situation worse.
    Thank you Joseph for all the information. This is a great site!
    Liz



  94. cena on August 8, 2017 at 1:19 pm

    i am getting so frustrated with all these nonsense,i don’t know why but all these companies are just extending their release date just to make us fool,i don’t want to waste any more time in this bullshit
    i am who i am i just have to accept that,i am going to shave my head i don’t want to hope for new treatment that’s it. i am done,and at last i want to thanks admin for doing great job keep it up.



    • Ken on August 8, 2017 at 3:22 pm

      I struggle with that myself. I was on the brink of cutting my hair two weeks ago but I have scarring alopecia which caused discoloration on my scalp. Furthermore I have a dark line across my forehead where my hairline used to be. I comb my hair forward and down so you can’t see it that clearly now. All my flaws will be visible if I cut my hair. That is the point. Not to mention I’ll be unattractive. I’m average now. However the convenience is tempting. It takes me up to an hour to “fix” my hair now. Sometimes a half hour. If I cut it, I could probably sleep a extra 40 minutes. Once you get past the mental and emotional hurdle then cutting it is the easy part.



  95. Bert on August 16, 2017 at 2:40 pm

    A bit crushing to hear about Histogen being pushed back till AFTER 2019 – that could mean anytime – 2022? I was hoping to travel to Mexico next year to try it, already had started putting the wheels in motion. Worried that in 2 years people will start noticing the first transplant I had done 10 years ago – it was just a small FUE operation. I can’t shave my head as it won’t look right when the small temple areas grow in again. My operation 10 years ago was a secret and done at a low point of low self esteem in my life.

    Why did Histogen delay the date by 2 years? Is there any clue as to when it could be on the market or is the best bet replicel?



    • Follicle Thought on August 16, 2017 at 4:49 pm

      I’m not sure why exactly. Hoping for good results from Replicel.



    • Derek Roberts on September 2, 2017 at 1:44 am

      Anybody try ru5881, just asking. Was curious.Mir seemed promising



    • Subhash on September 10, 2017 at 12:46 am

      Heyy broo so u safe gaurded ur hairs for 10 years that great broo and how was the results



  96. Biff Bigsby on August 16, 2017 at 7:54 pm

    Shame about histogen, but give it another year. They will make it. As for me: fin 1.5 mg a day / dut 1mg per week. Temporary MSP mixed with a sprinkle of caboki for density, and I’m probably going to give kelopesia a go next year. Results have been good so far for other readers.

    Thanks admin for all your work on this site.



  97. Hope on September 3, 2017 at 8:47 pm

    Does anyone know if Fidia brotzu lotion is on track for release in 2018?



  98. Tom on September 10, 2017 at 11:47 am

    I know we have a lot of treatments coming up, but just a thought from a fellow hair loss warrior….Note: this may sound incredibly silly and I’m no expert so please forgive me, but I was just thinking the other day:

    Most of these treatments now available and even the upcoming treatments seem to rarely target a receeding hairline in males and its extremely rare to find males who have found results/regrowth at the hairline/sides/temple region.

    But what if the cure or Atleast answers to what we don’t fully understand about males receeding hairlines lies within something we already have?…Females.

    Yes I’m aware of female patterened balding and that they do get thinning at their hair parting which can lead to hair loss, but Females do not get receeding hairlines like men do at the *frontal region*.

    I’m also aware of DHT, but hair loss and the root causes are still not fully understood.

    Sure this thought might’ve already been thought of long ago but it would be really nice if alot more research was done especially by new new hair loss start ups who are thinking about angles to tackle the problem to look more into females for answers.



    • Subhash on September 20, 2017 at 12:04 pm

      Will this ever become reality bcos im tierd im shaving of my head every alternate day and feeling alone in this world .will there be a treatment before i die and is it possible to see my hair again????



      • Follicle Thought on September 20, 2017 at 4:06 pm

        You’re not alone bro



        • Will on September 20, 2017 at 4:26 pm

          Hang in there boys. Remember there’s allot worse going on and I pray people with terminal conditions get cures before anything. I feel something is on the horizon very soon to grow hair and fix the scalp condition.



  99. Hope on September 22, 2017 at 11:41 pm

    So I found this article on a potential cure for baldness on the daily mail uk.
    There is a lot of ongoing research and many products/ drugs are in the works, it’s only a matter time before there are many options for all of us to choose from. The race is on…and these companies want to cash in on some profits!
    http://www.dailymail.co.uk/health/article-4791798/Drug-CURE-balding-activating-follicle-cells.html



  100. amir hoshiar on September 23, 2017 at 6:06 am

    Excellent package of information in one site,very informative,
    Thank you



  101. Lin on September 23, 2017 at 9:44 pm

    Hi
    I have got a question.
    Does Shiseido/Replicel’s hair regenartion treatment RCH-01claim to be same effective for both men and women?
    Thanks



    • Follicle Thought on September 24, 2017 at 9:34 am

      I can’t recall their stance on that, however cannot think of a reason why it would not be equally effective in men and women. Conventional wisdom is that some treatments (non-hormonal) have a tendency to work slightly more efficiently in women.



  102. Lin on September 24, 2017 at 7:03 pm

    Thanks Admin for the reply. As per Replicel’s website, their phase 2 trial involves 160 male subjects who will be under observation for 39 months. I was wondering why there are no female subjects this time while in phase 1trial there were 10 males and 10 females. This raised my doubt.
    Thanks



  103. Abdulaziz on September 26, 2017 at 7:46 am

    Hi admin,

    I read about RCH-10 by the CEO of replicel that this treatment will be available by Aril 2018

    Is it true and it will be available soon?

    Appreciate if u could reply

    Thanks



    • Follicle Thought on September 26, 2017 at 11:43 am

      I have not read this anywhere, please share a link. I wonder if people are confused that their dermal injector device is supposed to be market ready around April 2018.



  104. Tom on September 29, 2017 at 1:29 pm

    I am a transgender MtF, and the BIGGEST thing holding back my efforts to partially (as in on my own time or at work) present as a female (I’m married and have a son) is my very obvious balding. I’d take having my hair back over a million dollars any day.



  105. Abdulaziz on October 2, 2017 at 2:54 pm

    Hi admin,

    This is what it mentioned on the website

    Breakthrough: Japanese Scientists Use Stem Cells to Regenerate Hair Follicles in Bald Mice!
    Despite the myriad delays, it appears that we are much closer to a realistic hair cloning or hair multiplication technology than many people thought! In a new study published April 18 in the journal Nature Communciations, Japanese scientists report that they successfully grew hair on bald mice by implanting specially bio-engineered adult stem cells into the dormant hair follicles on the mice.



    • Follicle Thought on October 2, 2017 at 4:49 pm

      Oh ok, they are saying that years ago, on April 18th, 2014 (guess) they were able to grow hair on mice, unfortunately this does not mean Shiseido will be available in April 2018, however there is still talk that by the end of 2018 the treatment will be available!

      Thanks for sharing, I will delete some of the convo just for the sake of minimizing excess comments here, letting you know.



  106. Rick on October 3, 2017 at 2:35 am

    well organized, thank you for the work!! this cheered me up a lot as I am sure many of you know how difficult this struggle can really be.

    my girlfriend and I recently moved, we are a young couple that decided on a long distance relationship for convenient and strong job offers to help build a bright and happy future for both of us. I am NW3 and decided it was time to maybe tryout these current “FDA approved” hair loss treatment options and bought propecia.

    This was a big dilemma because of the obviously dangerous side effects. I plan to visit my gf every month and didn’t feel looking like I aged half a year every time I saw her, but it is also critical for me to maintain sexual performance whenever I do visit. I wouldn’t us to fight about such a sensitive topic that can ruin the relationship because of the drug.

    I am torn but reading this has definitely made me wanna throw propecia in the garbage, wait and see what 2018 might hold. I am optimistic! but easily my biggest potential concern is that maybe these treatments aren’t as safe as we think it is, especially after reading how brotzu is trying to dodge that long clinical testing. I would be more comfortable with the long testing. I Wouldn’t want to hear about similar problems to Propecia or that they are cancer inducing or something. our generation would be the true guinea pigs that will test these treatment or cures for problems. Good luck to all of us. We are almost there.



  107. Lin on October 10, 2017 at 10:48 pm

    I know many people are banking on Replicel’s treatment for their hair growth as I am. But I am shocked to see in their press release ( http://replicel.com/20170314-2/ ) from March 14, 2017 that “The largest increase in hair density over baseline observed in this group was a 21% increase at 24 months.” which I am sure not everybody will get.

    Admin,
    Is that it? Is that what we can expect at max?

    Appreciate your response.

    Thanks



    • Follicle Thought on October 11, 2017 at 11:28 am

      Hi Lin,

      Well, it certainly could be the max.

      I personally think results should improve from multiple treatments, as the result you are referring to was a one time dose. But what’s wrong with 21% anyway?



  108. Abdulaziz on October 11, 2017 at 2:19 pm

    Hi Admin,

    How many times you can do the hair cloning a year?



    • Follicle Thought on October 11, 2017 at 6:44 pm

      I don’t know because there is no treatment available on the market yet.



  109. Lin on October 11, 2017 at 7:05 pm

    Thanks Admin for replying.
    If 21% increase in hair what we are going to expect from Replicel’s treatment then why to wait, specially when there is other treatment like PRP or PRP/ECM combo already available in market which can give the similar boost I suppose. Please correct me if my assumption is wrong.

    Thanks
    Lin



    • Follicle Thought on October 12, 2017 at 10:02 am

      Ok, so once again no one knows yet at this point how things will work out, however I am sure Replicel is hoping for/expecting bigger results than PRP.

      Also, if PRP/ECM was giving 21% on average it would be a lot more popular than it is.



  110. Abdulaziz on October 12, 2017 at 7:01 am

    I am taking about the RCH-01 once it is available how many times u can do a year?



    • Follicle Thought on October 12, 2017 at 10:04 am

      Yes, Abdulaziz, none of those questions have answers now because the treatment is not available yet and patients have not been through the process enough to find out. You can make an informed guess yourself, 4 times a year seems reasonable.



  111. Liz on October 12, 2017 at 11:21 am

    PRP did nothing for me. Actually, it exellerated hair loss.



    • Jacqueline on October 12, 2017 at 10:22 pm

      PRP worked extremely well in the front of my hairline it’s just so painful wondering if anyone has had a less painful experience .



      • Kumar on November 5, 2017 at 11:06 pm

        I have had 4 PRP sessions in India over last 2 years. Hairfall stopped completely. I see a lot of baby hairs. Hoping they would improve. The doctor in India was wonderful. No pain at all. One more secret ill share, i apply organic aloe vera gel on my scalp after every bath. That also did wonder in stopping hairfall.



        • Priya on November 6, 2017 at 10:56 am

          Where did you get it done in India? Which doctor? Are you continuing the treatment? Thanks!



    • Pepperpot on January 22, 2018 at 1:33 pm

      Liz I know this is late but can you give details about you treatment? I’m particularly interested in how often you received PRP shots.



  112. Paul on October 12, 2017 at 3:18 pm

    Hi Admin,

    I recently stumbled across a treatment called Harklinikken but I am naturally skeptical. It’s a Danish company slowly infusing its products into the America market. Also, the New York Times just published an article about this treatment and how it looks promising. Any evidence/review/insights/opinions about this? Thanks.



    • Follicle Thought on October 12, 2017 at 10:10 pm

      A lot of people ask about this. All I can say is I don’t know much about it and haven’t seen pictures or heard from any readers who have used it with major success.

      Is it something worthwhile that can slow down or stop hair loss? Maybe, but it’s not something that seems compelling enough for me to look into at the moment.



  113. Abdulaziz on November 1, 2017 at 12:52 am

    Hi Admin,

    How are you?

    Long time no update almost two month and there is no any update

    Hope you will come with a surprise news and make all of us happy ?



    • Follicle Thought on November 1, 2017 at 11:06 am

      Abdulaziz, I’ve made a new article in the Articles section and several news updates in the Updates thread

      Have you seen them?



  114. Abdulaziz on November 1, 2017 at 3:20 pm

    I haven’t seen it I just saw it.

    So regarding the list above there is no unsafe yet especially RCH-1 where near to 2018 no confirmation when it will be available



    • Follicle Thought on November 1, 2017 at 3:53 pm

      I highly recommend bookmarking the webpage https://folliclethought.com/updates/ in your browser and subscribing to new posts via the email subscription on the right sidebar.



  115. Charlie on November 2, 2017 at 11:00 am

    Any news of RiverTown Therapeutics??

    Thanks



    • Follicle Thought on November 2, 2017 at 11:06 am

      Charlie, I also highly recommend you bookmark the webpage https://folliclethought.com/updates/ in your browser and subscribe to new posts via the email subscription on the right sidebar of this blog.

      RiverTown just released their latest available news in an article found on the front page of the site.



  116. Scott on November 16, 2017 at 1:31 am

    Do you have a best step by step model, to regrow hair on your own, now? 🙂
    Heard about a dermarollers, is it recomendable??



    • Follicle Thought on November 16, 2017 at 10:22 am

      I don’t really, Scott. I use one cream on a daily basis and that’s it. Have never spent consistent time dermarolling. I’m looking for the next gen products to help my hair. Anyone care to chime in for Scott?



  117. Lin on November 16, 2017 at 7:52 pm

    Hi Admin,

    Would you mind revealing what cream are you using? And what is your opinion about Reboost now as it has been sometime now since its release.

    Thanks
    Lin



    • Follicle Thought on November 18, 2017 at 10:15 am

      I’m now using Geminis cream, it’s a newer version of N2C cream. Not endorsing it because I’m not sure of it, but think it helps. I still use Reboost on top of it once in a while.
      Reboost still has not shown to be impressive as far as I can tell.



  118. Rahul Suresh Dingankar on November 24, 2017 at 2:25 am

    Hi FT team
    Recently I read about some south Korea’s treatment “CXXC- type zinc finger” can you get some information about it



  119. Hope on November 27, 2017 at 9:24 pm

    Hi Admin,

    Any word on when Fidia’s Brotzu lotion will be released ? I was expecting by 2018? Is there any word when?

    Thank you



    • Follicle Thought on November 27, 2017 at 10:04 pm

      Hi,

      Possibly by the end of 2018. They have been quiet and were not concise on whether they meant before 2018 or before the end of 2018.



  120. Alex on November 30, 2017 at 10:47 pm

    You’re a total babe, Joseph. This site gives me major hope every time I come in to check on hair loss treatment progression. Replicel in particular is the one I’ve got most of my apples in for. For now 1 mg of propecia a day with .5 of dut will hopefully hold the damn floodgates.



    • Follicle Thought on December 1, 2017 at 9:34 am

      Haha, well thank you.



  121. dan on December 7, 2017 at 8:37 pm

    went to a dermatologist today. he said all things that can be bought for restoring hair are bull****! his words not mine. so he said only thing to put back hair on my head ( stop losing hair) is a hair transplant. thats it.
    (Edited)



    • Follicle Thought on December 8, 2017 at 2:28 pm

      Hi Dan,

      Yes there’s really no optimal treatments out there currently, hence this article is a list of the most promising new treatments on the horizon for growing hair.

      Hair transplants will not stop you from losing hair, however they are the only way to basically guarantee significant hair restoration. Stay tuned. ?



      • Subhash on December 20, 2017 at 7:48 am

        Hi admin the share value of replicel is almost hitting ro zero .all investors are taking the money back i guess replicel is not even going to launvh the product by end of 2018



        • Kev on December 31, 2017 at 4:21 am

          Replicel can’t decide if they are going to launch the rch-01, since shiseido owns right to market the product.



  122. Raza on December 17, 2017 at 1:46 am

    Hi there,
    I’ve recently got some positive news about “Vichy Dercos Neogenic” product. Can you help me decide to apply or not this treatment.
    Regards



    • Follicle Thought on December 17, 2017 at 12:04 pm

      Hi Raza, maybe another reader can help you. I’ve never used the product. Regards



  123. Sheila Mizrahi on December 18, 2017 at 2:25 am

    Hi admin…can you tell us how your trial run on Reboost was working??
    My doctor here says he’s afraid not all the ingredients may be FDA approved here. Was wondering if you noticed any change??
    Thanks
    Sheila Mizrahi



    • Follicle Thought on December 18, 2017 at 10:11 am

      Hi Sheila,

      I’ve used Reboost on and off since it first arrived around June. I’ve also used other creams along with it. I have noticed an improvement around the thinning edges of my crown. Not a dramatic improvement. I can’t say that I would recommend it to someone for the price it is. Many people have noted the cream is very greasy and I think it might work better if it reached the scalp more effectively.



      • Sheila Mizrahi on December 18, 2017 at 10:36 am

        Interesting… perhaps that’s why they are now offering a needling roller tool?? Hmmm
        Sheila



  124. Karim on January 1, 2018 at 11:32 am

    it Means there is no cure for 2018? We are waiting for miracles!



    • Manish on January 2, 2018 at 7:39 am

      Ammeen



  125. Manu on January 3, 2018 at 2:30 pm

    Fidia never said the lotion will be out by end of year. They say “although we envisage the development of the potential product candidate being completed by 2018”. I think that hardly means the lotion will be “out for public”.



    • Follicle Thought on January 3, 2018 at 3:28 pm

      True, yet it is highly implied this lotion will be out to the public by the end of 2018.



  126. Someone on January 19, 2018 at 5:39 pm

    Hurry up please before the body changes start. We want to enjoy hairs when maximum 40 otherwise it useless for me 🙁



    • D.A. on January 24, 2018 at 3:41 am

      I am already past my mid 40s and quickly heading into late 40s. My entire social life and relationships have suffered severely since I was about 19 years old. I guess they’ll figure out how to make or restore hair by the time it’s too late for me to have hardly benefit at all. I will get to spend my old age seeing nobody else has to be bald like I was. Ain’t life a b**ch!

      DA



  127. Hopeful on January 21, 2018 at 9:07 pm

    Hello

    Could you please update on Setipiprant developed by Kythera?

    I recently read that it really worked wonders.

    Do you know any lotion that can be applied topically to enhance hair growth?



    • Follicle Thought on January 22, 2018 at 10:33 am

      Please check out the latest 2018 article in Articles section



  128. Adam on January 31, 2018 at 7:40 am

    Wow



  129. IWudLookGud on January 31, 2018 at 9:52 pm

    Great job. Following.



  130. Tony G on February 3, 2018 at 10:30 am

    Hey guys,
    Regarding Replicel, how effective will it be to combat hair loss if indeed it is released in late 2018? Will it give a Norwood 3 a full head of hair or is it something that will give modest results like minoxidil?

    Looking forward to hearing your thoughts seeing as this was forecast to shake things up this year. I was thinking off putting off a HT this year to see how replicel plays out.



  131. Vince on February 5, 2018 at 4:45 am

    Researchers have developed a method for the mass preparation of cellular aggregates, also known as ‘hair follicle germs (HFGs)’, that may lead to a new treatment for hair loss.

    https://www.sciencedaily.com/releases/2018/02/180201142853.htm



  132. June on February 5, 2018 at 5:57 pm

    Are there any prospects for hair removal?



    • Follicle Thought on February 5, 2018 at 8:56 pm

      Follicum may have something but it’s only at the preclinical stage.



  133. Sevl on February 7, 2018 at 5:20 am

    Does anybody know how long it will take that RCH-01 (Replicel) gets on the market in Europe (and the US) after the launch in Japan? I think thats the question for a lot of people at the beginning of hairloss. In my case I think about taking Propecia to bridge the time till it gets launched. But I just would do it, if I get to know that I dont have to do it for more than one (or maybe two) years.
    Certainly there has to be found a company like Shiseido for Asia to get to the market, but that is not the problem I guess. As long as the new results (comming soon) of the latest phase are positiv. More interesting is, at least for me, does anybody know how long it will take (at the minimum and the maximum) to get an approval in Europe (and the US) after the launch in Japan.
    In my thinking there is a whole series of steps before somebody outside of Asia can get this treatment. Find a companie…get an approval…build machinery for the injector and the growth medium (for millions of people)…train the surgeons…be the first in line…..this could take ages and I cant imagine that Replicel, Shiseido and the “baggers” are willing to wait that long.
    This all would be so much easier if Shiseido decides to do it in Europe and the US also. The will be from fourth to the top of the cosmetic companies within one year. I dont want to be forced to fly to Japan twice in 10 weeks. That costs more than the treatment itself (Probably around 1000 €/$ as I read. Dr. Rolf Hoffmann said also in an interview that it will be affordable for everybody). And if you have bad luck you cant get in the country because of the fact that yor second visit is to close to the first one and than yo get an entry ban.
    I dont want to awfulize everything. I also think that Replicel is the most promising star at the sky, but there are so many questions left.
    With “When will it be available in EU/US” leading the way. Followed by “How much will it really cost”, “How long does it really take”, “Will it stop hairloss forever or will it be re-newed every 5 years”

    I dont want to have blind guesses. Just knowledge of how the approval-procedure in EU/US works and how long it will take will be very helpful.

    Thanks



    • Tony G on February 9, 2018 at 1:05 pm

      Hey mate, good post.

      Do you know how effective RCH-01 (Replicel) is actually going to be? Will it be a panacea or just give modest results like minoxidil?

      I am eagerly awaiting news as well. Fingers crossed this works.



  134. Dr.S.I.Quadri on February 10, 2018 at 5:47 am

    I had great hopes from River Town Therapeutics.Unfortunately it is still collecting funds for last couple of years! Will it ever start any trials?
    (Edited)



    • Follicle Thought on February 10, 2018 at 10:54 am

      Hi Dr. S.I.Quadri,

      RiverTown will start their trial as soon as they acquire the necessary funds for the trial. Are you able to help contribute to their funding or know anyone who could?

      (P.s. I understand your disapproval of a certain international hair growth cosmetic. Follicle Thought has listened to feedback like yours and moved on from this subject. The best method to prove a point is to stop mentioning the product which is why your comment needed to be edited.) 🙂



      • lynne neveuboucher on February 12, 2018 at 3:31 pm

        Im very interested in the coming year of what can be done as,far as cloning hair follicles.



  135. O.G Biotech on February 26, 2018 at 4:44 pm

    Hi
    Historically speaking is it normally for it to be so many companies working on so many different drugs and treatments for hair loss? Or is this an increase that has taken place during the recent years?



    • Follicle Thought on February 27, 2018 at 7:46 am

      This is the highest amount of companies I’ve known about in the past decades. ?



  136. Hope on February 28, 2018 at 9:17 pm

    Hello,

    What are the chances of a new product actually getting released to the general public in 2018….namely Fidia Brotzu lotion? They have not shared any further information since their update Jan 2017?



    • Follicle Thought on February 28, 2018 at 9:21 pm

      Hi, Please see Quick Updates section for latest on Brotzu lotion.



  137. Hope on February 28, 2018 at 9:50 pm

    Thank you ! Good news regarding Brotzu – fingers crossed ?.

    I didn’t notice the quick update section?



  138. Hopeful on March 10, 2018 at 5:55 am

    Hi, I wasn’t sure if people are aware, but I have found a doctor who is treating alopecia areata with tofacitinib cream. I’m posting this so others can see. All you have to do is find a doctor who will prescribe tofacitinib but you have to acquire it at a compound pharmacy and the catch is that it is about $1500. So, do it at your own discretion. This is basically Angela Christiano’s method. A topical JAK inhibitor.



    • Jason Aubrey on April 4, 2018 at 8:49 am

      hey, I just read your post. What compound pharm did you go through. Ive been waiting for a topical to come out. i just didnt know where to get it and how to apply.Thank you, Jason



  139. Chris on April 9, 2018 at 9:43 am

    Hey would you be able to update/post link of the presentation that Dr. Brotzu will give after its uploaded? Cheers



    • Follicle Thought on April 12, 2018 at 9:56 pm

      Will update it with everything I can…



  140. Ali on April 22, 2018 at 7:50 am

    Thanks for gathering the latest studies in one page.
    But which of the above researches will have a certain result and really will be able to regenerate the follicles- and WHEN it will be available for everyone?



    • Vince on April 23, 2018 at 1:10 am

      Ali, no offence but what kind of question is this. The guy behind this site is basically sitting on the same information that you are if you read through it all, he’s not sitting on a crystal ball that has all the exact answers here.. I for one appreciate that he’s putting his time and effort to compile and share it all, please



  141. T on April 23, 2018 at 2:52 pm

    Great guide. Thank you!

    I just turned 50 and have been fighting this battle for about half my life. Started with minox (injections and then topical), some Indian “Anoop” at some point (icky, messy stuff that didn’t seem to work), and for the last 8 years or so, Finasteride and transitioned out of Minoxidil after 6 months. I somehow have managed to keep some hair still (Norwood 4?), considering how early I’ve started losing hair.

    Funny thing is, many pals who used to tease me in my youth are now completely bald and I am still somewhat better off. 😀

    Meantime, while awaiting for the magic to happen, I’m on my 3rd day trying this nondescript ( it just says “hair grower” and made by Herbs, Inc.) topical by a Filipino herbalist who has guaranteed results in 2 1/2 weeks or my money back. Optimal use, he says is 2 months. Whoa? Let’s see. As far as I’m concerned, the $30 usd for a month’s supply is dirt cheap if it works and a waste if even just a buck for something that doesn’t.

    It needs to refrigerated as it is 100% organic. Though not all will be disclosed it includes an aloe from a California monastery, Benedictus, and Clitoria ternatea. Fingers crossed with not too much to lose. 😀



  142. Hope on April 23, 2018 at 10:28 pm

    Any idea what the chances are of Brotzu lotion being released this year? Fidia has been very quiet and there has been no formal announcement since the hair conference in Naples?



    • Follicle Thought on April 24, 2018 at 10:24 am

      It seems very plausible that the lotion would be released this year sometime.



  143. Anita on April 30, 2018 at 12:37 pm

    Hi I am looking for a treatment for hair loss.
    thanks



  144. BUKOLA on June 15, 2018 at 9:47 pm

    DIS TREATMENT WIL B SAVING SO MANY LIVES IT IS BEEN RELEASE INTO THE MARKET WERE IT IS ACCESSABLE TO D PUBLIC BECOS (AA)ALOPECIA ARETA HA TAKEN AWAY SO MANY THINGS 4RM ME AND I KNW THERE ARE SO MANY PEOPLE OUT THERE WHO ARE SUFFERING 4RM DISAME PROBLEM WITH NO ANSWER OR DEFINATE CURE IT AN EMOTIONAL PROBLEM DAT AFFECT A PERSON PSYCOLOGICALLY AND AM HOPIN THAT A PERMANET CURE IS FOUND SOON SO HAS TO HELP SAVE MANY LIVES



  145. Laura Elena Guida on June 21, 2018 at 11:13 am

    Thanks for providing this detailed guide. Please continue keep us informed!



  146. Dave Ochieng Owange on June 28, 2018 at 12:06 pm

    I’m in Kenya right now and I’m experiencing baldness at 24 years old. How can I get treated and which procedure should I follow to to ensure regeneration of my hair…



    • Follicle Thought on June 28, 2018 at 3:58 pm

      Dave, please read up on the site. Later this year may bring new treatments to the hair growth market.



      • Jose on October 1, 2019 at 11:55 am

        Did it happen?



  147. Gutierrez cirilo lampong on July 11, 2018 at 5:00 pm

    Good day…i need a solution for my hair loss…what can you advice or how can i buy brotzu lotion



  148. Mikeal Shaffner on July 22, 2018 at 1:51 pm

    I need hair



    • Flvv on September 4, 2018 at 12:56 pm

      me too, from an eternity.
      Many beautiful words but only words remain



  149. Kira on August 24, 2018 at 12:43 am

    @admin: did you forget about P3074 ? It is the only thing that have completed phase 3 now.



  150. Flvv on September 4, 2018 at 12:53 pm

    Before to die i hope to feel me normal. I know, it’s stupid but i spend my stupid life to hope . So sad.



  151. mabbw on September 21, 2018 at 4:37 pm

    Do you treat young children. my daughter is 3 years old. She has Alopecia Ariata since she was 1 year old.



    • Follicle Thought on September 21, 2018 at 5:00 pm

      Please contact a dermatologist. They would know if is suitable to treat children. Thanks for reading and supporting Follicle Thought.



      • mabbw on September 24, 2018 at 3:35 am

        no they dont do enything…



  152. Gen Jo on September 25, 2018 at 3:11 am

    I am 35. Losing hair since I was 20. I am a girl and it really sucks.

    My wedding is planned for next year and I feel really conscious because of my hair.

    Do you think Brotzu solution will be available by end of this year?



  153. Paddy on October 15, 2018 at 1:40 pm

    I am in my mid-60s and I’m sure my hair loss has been going on for years but only now has it gotten to such a noticeable point. I’ve been told my kind of hair loss is genetic and that laser treatment is essential to stop hair loss. I was told by the same person, purveyor of the laser treatment, that no topical treatment will work for me.

    Is this true and what are the options for older women like myself?



    • Follicle Thought on October 15, 2018 at 4:33 pm

      Paddy, for the treatment options that are available now the laser specialist’s advice may be accurate. The current treatments may not offer you much in terms of regrowth. I am not a strong advocate of laser therapy either though, so please do some thorough research on the net.

      However, in the coming months and half years, etc. there are newer and more efficient hair growth topicals coming out that may be of use for you. So stay tuned and check the Updates page and the front page of Follicle Thought for news.



  154. Mike on October 22, 2018 at 5:14 pm

    what about the artificial sandalwood treatment? it is not on the list.. do you think it’s scam?



    • Follicle Thought on October 22, 2018 at 11:19 pm

      I don’t think it’s a scam, it’s an over the counter treatment which has showed no visual human data yet. There are certain credentials to make it on this list.



  155. Mari on November 23, 2018 at 4:39 pm

    Hi, I´m a women of 29 years.
    I don´t have hair loss or any kind of baldness. The problem I have is haven´t recovered a big amount of hair that I lost five years ago due to an hormonal treatment called Dercutan.
    I need finding a growth treatment to have more new hair, strong and thick, as I used to have.
    Please talk with me about this, I´m really worried.
    I just seen that “Brotzu Lotion” will be on sale soon. Is that true?
    Do you think that is an effective way to recover hair lost?



    • Follicle Thought on November 23, 2018 at 5:08 pm

      Yes, if the information is written here it is currently believed to be true. I can’t say for sure how effective the treatment will be but he have good hopes. What needs to happen is for the product to release on the market and we all observe the results people are having with it. Best wishes and I hope this helps. There is help for you with one or several of these treatments coming, continue to watch and you will find a solution.



  156. Gg on December 6, 2018 at 8:53 pm

    Besides JAK inhibitor is any of the new tech such as Shiseido’s offer a chance for ALopecia areata patients?



    • Follicle Thought on December 6, 2018 at 9:39 pm

      There’s a few companies working on areata, but I don’t think Shiseido will be effective for it. Check Birch Biomed.



  157. Jeff on January 5, 2019 at 12:23 pm

    Why have you not updated the status on the products? Its been a while.



    • Follicle Thought on January 5, 2019 at 2:18 pm

      Busy writing articles for the site when I get a chance…also news for this list typically comes slowly over the course of months.



      • paramdesh29 on February 16, 2019 at 5:37 pm

        So did Shiseido end up making any announcement in Sept/Oct of last year?



  158. Hagai on February 18, 2019 at 4:47 am

    Hi and thanks for the articles and updates!
    I just wondered, why moderate hair transplanting technics, such as FUE,
    are not menthened here.
    Great results are shown by FUE already nowadays.
    Thanks again and keep up with the great job!



    • Follicle Thought on February 18, 2019 at 10:27 pm

      I try to stay away from the hair transplant conversation because there is a lot of money involved in doctors who already offer these treatments and other websites exist to evaluate hair transplant surgeons.



  159. ana on March 10, 2019 at 7:22 pm

    o tratamento Replicel quando será comercializado?Ainda não se sabe qual será o preço do tratamento?



  160. stefan on March 11, 2019 at 4:57 pm

    Any news , updates about Dr Brotzu cream, if people see any results?



  161. Jeng on April 3, 2019 at 6:06 am

    Any progress on above? still no news and people are waiting desperately.

    I wanted to know more on toppers if someone can help. How do you choose one and buy?

    Thanks



    • Jackson Fields on April 8, 2019 at 8:54 am

      Yes my question never has been answered either.



    • Follicle Thought on April 8, 2019 at 1:57 pm

      Unfortunately there is not definitive news about these companies. There tends to be a wait for these things, hopefully news comes soon.



      • Jackson Fields on April 9, 2019 at 9:34 am

        Thanks!



  162. Ftl on April 27, 2019 at 2:30 am

    I have to say I believe the dates for these treatments to be released for a few of the companies is wildly off. No way companies in phase 2 now will have products released in the next year or two. Samumed has already stated they won’t even have results of phase 3 until H2 2020..so no way they bring a product to market by 2020. Aclaris is off too, same with rivertown and follica.



  163. terry on June 5, 2019 at 4:42 pm

    Could you please let me know about your thoughts are on Nanoxidil (Spectral Dnc-N) from Ds Laboratories? Any detailed information would the product or opinions about it would be helpful, I couldn’t find anything on your site about it. Thank you!



    • Follicle Thought on June 6, 2019 at 11:15 am

      I don’t know much about it, but I believe its relative to minoxidil, a product which has been available for 30 years.



  164. faust on July 1, 2019 at 3:24 am

    Hey Follicle Thought is this “new cosmetic stem cell topical” one you’ve been teasing us about in few last posts?



    • Follicle Thought on July 1, 2019 at 11:17 am

      The stem cell topical I’ve referred to is all the same one, however the idea is not to “tease” people but rather give them a bit of hope that something new and promising is on the horizon. Since my intention is not to tease anyone I’ve decided to remove it from the list and I’ll get back to it once the update is ready.



      • Dimitri on July 24, 2019 at 11:07 pm

        Why isnt stemson, tissuse or l’oreal on here yet



        • Follicle Thought on July 24, 2019 at 11:09 pm

          Tissuse will be on next.

          Truth be told, Stemson and L’Oreal may very well be still 2 years out from a clinical trial, but they will also be added soon. Sometimes the very advanced companies are a long ways away. Hopefully some other shorter term treatments will be making the list soon too.



  165. Greg on July 2, 2019 at 3:13 pm

    @Follicle Thought Are you going to make a separate section for Stemson Therapeutics or is it just too early?



  166. Sophie Nigam on July 10, 2019 at 3:06 am

    Really nice article!! I like this article. It’s really helpful for those people who are suffering from hair loss. Thanks for sharing such a piece of amazing information.



  167. Benji on July 28, 2019 at 5:52 pm

    There’s only Tsuji and Stemson and possibly Rapunzel that are even remotely credible. The whole hair loss industry is full of sharks and shysters who make a killing praying on desperate and gullible individuals. It’s totally corrupt and unethical, as any one with eyes can clearly see.



    • Follicle Thought on July 28, 2019 at 6:16 pm

      The nice thing for the most part is all of these treatments are not putting people at risk, they are not offered to patients yet.

      Wouldn’t it be nice if a treatment actually came to the forefront and surprised us?



  168. Frank95 on July 28, 2019 at 8:04 pm

    Hi, where is Polichem’s topical finasteride gone? It’s not in your August pipeline…can you explain why?



    • Follicle Thought on July 28, 2019 at 8:07 pm

      Hi Frank, thank you for commenting. Well, the main reason is that topical finasteride is already available everywhere around the world. It’s not a cutting edge therapy.

      It’s also a difficult drug to form an opinion on. It’s the best option we have at maintaining hair, however it’s not full proof and has shown serious side effects in lots of patients who take the drug. It’s one of the main reasons people are so eager for new therapies. Are you eagerly anticipating Polichem?



      • Züfer Zafir on July 28, 2019 at 9:43 pm

        Hey, why is Medipost /celinos ngf 574 not on the list? Is it not to be released soon?



        • Follicle Thought on July 28, 2019 at 9:53 pm

          Hi Zufer, the ngf product is coming out as over the counter, and so it comes with a catch 22. Everyone wants to know how well it will work in the market, but does not support the idea of introducing it to the market because if it happens to not perform as expected then people will ridicule any website who introduces it. Reasons like that are why I have halted coverage of the product. It won’t be available internationally for a few months anyways, Celino’s plans for a webstore are not definite at this time.



      • Frank on July 29, 2019 at 11:10 am

        I’m waiting for it a lot honestly, when do you it’s gonna be commercialized? 2020 maybe?



        • Follicle Thought on July 29, 2019 at 11:22 am

          It should definitely will be out in 2020.



  169. Frank on August 1, 2019 at 6:01 pm

    What’s exactly this “tissue” you mentioned on the list?



  170. Antonina Camillo on August 7, 2019 at 11:02 am

    Hi could you tell me when this treatment is available in Australia Perth



  171. ahluwaliaraman@yahoo.com on August 22, 2019 at 6:30 pm

    is this available in usa?



  172. Vince on September 15, 2019 at 12:54 am

    Thank you as always for this website that keeps us updated and filters the vast web! please know that there are those of us that appreciate your work! in therms of the pipeline above, seems like it needs an update in regards to recent market updates. thanks and best regards



  173. Jose on October 1, 2019 at 11:52 am

    When will something be available? 🙁



  174. Victoria Ogburn on October 17, 2019 at 9:02 pm

    Thank you for the info ! Would you be willing to please answer IF Lazer Caps do work?? My scalp cant handle Minoxidil and hopped it my be a option. Any chance you could do a update review on what is out there now. Much appreciate your time,
    Victoria
    GA, US



  175. dale2 on November 8, 2019 at 9:45 am

    Hi there, how come ALM12845 (formerly P-3074) is not listed here? It could be released as early as end of 2020..



    • Follicle Thought on November 8, 2019 at 12:58 pm

      Hi Dale, the main reason is that ALM12845 is topical finasteride which is already widely available in the US and other countries. It’s a good product but the focus of this list is for new treatments with new mechanisms of action.



      • dale2 on November 8, 2019 at 4:38 pm

        Thanks, that makes sense, although the HPCH technology could set it apart from all the compounded solutions out there… not to mention that there are several studies addressing this specific formulation. Another candidate for this list would be the liposomal gel version.



      • Frank on December 9, 2019 at 4:17 pm

        Hi Admi, which treatments are the most promising for 2020, please keep me updated



  176. Arjun on January 14, 2020 at 4:38 am

    Thank you for sharing this information. This article is very useful for those who are having the excessive hair loss.



  177. Dorime on March 25, 2020 at 9:46 am

    Because of the Corona-Virus most of the Trials are postponed. Also some further Information, Like price range, are given for some of the Treatments. For example Breezula will cost 100-200$ a month, which is a lot, mostly for Young People who suffer from Hair loss.

    The Problem is, that Most of this Treatments should be used in the early Stadium of Hair loss, while there is a Lack of Treatments that focused on Hair regrow for bald People.



    • Follicle Thought on March 25, 2020 at 11:18 am

      There is no price given for Breezula at this time, only speculation based on the prospective price of Winlevi, the acne version of the drug. But, even Winlevi is not out on the market with a definitive price yet. Let’s see how it all goes.



      • Natif on March 29, 2020 at 5:07 am

        Hello, any advice on what topical solution to use in order to slow hair loss? I was on Finasteride pills and that worked great but I had some of the side effects and stopped it. Now I am using some korean ginseng based topical spray, but I don’t much results…



        • Follicle Thought on March 29, 2020 at 11:58 am

          Hi Natif, have you considered topical finasteride or minoxidil?



          • Milagros on July 31, 2020 at 3:39 pm

            Hi, what treatment would you recommend for diffuse hair loss in women. Im willing to do a transplant like the one offered by Tissuse or.But Id like to know the best option I have considered hair cloning too.



          • John on September 8, 2020 at 1:33 pm

            Hi admin. I see on the graph at the beginning of this page that Shiseido/Replicel’s bar is all the way to the end – Phase 3 (indicating the final stage). If it is in fact in the final stage, why is the Market Release date so far from now (2024) ?



            • Follicle Thought on September 8, 2020 at 2:10 pm

              John, because Shiseido completed an equivalent to phase 3 study in Japan and the results were not sufficient enough for them to market the treatment. They have said they are interested in doing another trial with more injections to see if the results are better.



  178. martin on April 21, 2020 at 7:30 am

    Really nice information about PRP hair transplant treatment. Thanks for sharing.



  179. Harris on December 19, 2020 at 11:25 am

    Hi Admin,

    What a grim looking future for the treatment of hair loss. So many promising advances in science and technology in cellular based treatments, now reduced to a few minoxidil-like topical ones. I saw that Histogen has gone down a notch. I wonder, and maybe you do too, the results that were to be announced this month, now extended to February, could that be because they still don’t have the results they were hoping for and are now hoping to see them by February?



    • Follicle Thought on December 20, 2020 at 4:33 pm

      I agree to an extent that yes, they are hoping that within the next few weeks there is more statistical evidence that HSC is increasing hair count.



      • Harris on January 3, 2021 at 6:57 pm

        Well cellular-based treatments are the most effective means and they all appear to be going under.



  180. Vineyard on January 28, 2021 at 5:54 pm

    I dont understand what God wants from our hair, the more I see it getting less every day, the more I feel sad : (((



  181. Harris on January 31, 2021 at 4:03 pm

    It doesn’t make any sense. We can put people on the moon, build space stations, bring people back to life at near death, but still can’t cure a human ailment. There must be something hidden.



  182. Ralph Wiggum on May 4, 2021 at 6:24 pm

    Yowza, what happened that pushed Follica out to 2023?



    • Follicle Thought on May 4, 2021 at 6:59 pm

      Hi Ralph, they seem to be pretty quiet/stagnant at the moment.



  183. Jose on May 8, 2021 at 11:24 am

    Do you have any information on possible products that make hair grow? According to an article, a shampoo with marine avicennia extract that could make hair grow was going to be commercialized and it was going to be commercialized in the middle of this year



  184. Tony on May 9, 2021 at 7:22 am

    I assumed that Tissuse/J. Hewitt, were not continuing apparently they are still alive?



    • Follicle Thought on May 9, 2021 at 10:28 am

      Yes Tony.



  185. Thor on May 28, 2021 at 12:29 pm

    Hi Admin,

    Thanks for all the work you do. I have a quick question about Biosplice/Samumed.

    Changes in regulation of Wnt signalling have been linked closely with cancer.
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4841194/

    What are your thoughts on the safety profile of Dalosirvat? Especially considering that 90 days or even a year of exposure might not be enough time to understand the long term effects of this on something as difficult to detect and progressive as cancer.

    Thanks!



  186. Follicle Thought on June 14, 2021 at 6:57 pm

    Thor, sorry about the delay. I didn’t notice that the question was re-posted.

    I think, if dalosirvat is approved for use by a regulatory agency, its safety profile would be pretty strong. Dalosirvat is a mild Wnt pathway stimulator, thus, it should not pose risk for causing something like cancer when used topically. In any event, this is what the regulatory agencies are for, to determine whether a drug is suitable beyond scientific/reasonable doubt to be used by humans. The phase 3 trial was observed for 48 weeks in patients, that should give Samumed enough time to investigate its biological effect.



  187. Horsy on July 24, 2021 at 8:40 am

    Hey Admin,

    thanks so much for your work.

    Two things: 1) Biosplice has not mentioned the completion of Phase 3 Study in Turkey. Is that bad news? Have you been in touch with them?

    2) In August 2020 Prof. Vogt from the Clinical Research Center in Berlin has spoken a on dermatology congress about a big phase 3 study on topical finasteride. Since then I have not heard anything, neither have I found information on the internet. Do you have further information?

    Again, thanks so much for your work!!!



    • Follicle Thought on July 24, 2021 at 2:39 pm

      Thanks Horsy.
      1) I don’t know, they cannot reveal anything substantial to me.
      2) Was it the product from Almirall? It likely was. It’s supposed to launch, but I don’t know when.



      • Horsy on July 26, 2021 at 5:44 am

        Thanks so much for the quick reply!

        1) They can not reveal anything due to legal reasons or do you mean they simply refuse to answer? In your experience, is it rather normal that the analysis or evaluation of a phase 3 study takes that long since the study was completed in December 2020?

        2) I am not sure if it was a study for/from Almirall but the dates don’t seem to add up. I have contacted the professor. Not sure if/when she’ll reply but I make sure to share any news.



        • Follicle Thought on July 26, 2021 at 1:24 pm

          Regarding Biosplice/Samumed, there hasn’t been a phase 3 in over 20 yrs so it’s not easy to compare. It does seem a little odd to me that they have been completely silent, however, there is no definitive conclusion about what’s going on with their phase 3 data. We simply have to wait.



  188. Sonic on July 25, 2021 at 1:41 pm

    Hi admin, there’s been an update on Yokohama University (hair multiplication) in May 2021 saying that they plan to finally start trials in humans in 2023.

    I think that’s really good news and would be nice if we could get a little article on it, would help to show Tsuji and Stemson that there’s others aiming to move quicker than them as well.



    • Follicle Thought on July 25, 2021 at 3:07 pm

      Ok, I’ll see what’s up Sonic.



      • Sonic on July 25, 2021 at 3:58 pm

        Thank you, I’ll send you an inbox message with a link 🙂



  189. Sonic on July 27, 2021 at 1:08 pm

    Hi Everyone

    Have you heard about CRISPR used for Gene Editing Therapy?

    It’s personally my favorite for the possible cure against male pattern baldness.

    If you’re not very familiar with CRISPR, or even if you are, I strongly advise you watch the short Netflix docu-series called “Unnatural Selection”.

    It is brilliant and it’s done by a guy who has a PhD and also worked for NASA.

    They have already done things like regrow limbs in insects, merge characteristics of different living creatures, like taking the DNA that makes a firefly glow and injecting it into a mouse/rat and it became a glow in the dark mouse.

    In the first episode of Unnatural Selection you will see how they used CRISPR to inject DNA found in the stem cell and embryo of mice into mice which were very old, towards the end of their life, hunch-backed (spinal bent just like how old humans sometimes get hunched-backs), slow moving/mobility deteriorated, their hair/coat looking old, etc

    The result, was the mice that were injected with the DNA found in the embryo of mice, turned into a much more youthful mouse, NO hunch back, restored mobility to youthful days, sheek and young looking hair/coat, and it was said that the life span of the mouse was extended by approximately 30%.
    Which is massive!

    Basically the cells in the mouse were restored to a younger state, making it far more youthful. It was amazing. Like drinking from the fountain of youth.

    Heck if their able to do that to humans in some way they might not even need to know the exact molecule signals to turn on and off to target male pattern baldness specifically.

    But of course people would also
    still like to find the exact signals to turn on and off.

    The only thing slowing down the Gene Editing technology was ethic boards who were resistant to changes been made in humans via Gene Editing Therapy.

    When Engineering things, especially genes, you need to start with the smallest change that would produce a favorable result and then scale up, for that reason the treatment was delayed and first started on mice and other plants/animals before moving to humans.

    The fact that they used CRISPR in vivo* recently is massive and the fact that it cured a rare genetic optical disease is even more amazing.

    It definitely means a lot more is to come from CRISPR in terms of in vivo applications with restrictions starting to lighten slowly. Its a huge move in the right direction.

    Even NASA scientists recently used CRISPR in space* very recently for the first time.

    The great thing about CRISPR is that is so easily accessible, usable and cheap that it’s being used by a lot of people recently and also that means it’s being used in a variety of applications not just Cancer or a few diseases.

    Also, Moogene Medi is one of the first Gene Editing companies that is already working on using CRISPR to treat Male Patterned Balding. It is doing this alongside trying to separately use CRISPR to treat Colon Cancer. Yes they are working on both diseases at one company simultaneously, just like many other companies will hopefully also start to do.

    I know that Gene Editing Therapy is already being used on many different diseases like It’s being used for people with many cancers, sickle cell anemia (40+ people cured from the trials to date), cystic fibrosis and many more to come in the short-term.

    It’s being used to treat the #1 genetic deficiency in the US, hemochromatosis.

    And they’ve even found more tools passed Cas-9 such as Cas-13

    I really hope we see a lot more CRISPR based approaches to tackling Male Patterned Balding 😀



    • Jade on December 4, 2021 at 1:02 pm

      Hi Sonic, I haven’t heard about Mogene Medi in a while, do we have an update from them?

      I think they are in Phase 1 clinical trial at the moment, how long would it be in order to get this treatment in clincs?

      I also read that their CRISP method would stop balding but won’t be able to reverse hair loss for the most part.

      Am I correct?



  190. RandomMonk on July 29, 2021 at 6:31 pm

    Hey Admin,

    Do u know when it will be possible to buy the minoxidil booster from Applied Biology?

    Thanks



    • Follicle Thought on July 29, 2021 at 7:08 pm

      I don’t know, last time I heard, Dr. Goren from AB told me that they have partnered with a company in the US who will commercialize the product sometime in 2021.



  191. Menscript on August 6, 2021 at 6:29 am

    Thank you so much for sharing, most people are suffering from hair loss, you are not alone. Millions of men and women all over the world have suffered from hair loss. In fact, there are more people who are suffering from hair loss than we want to admit. This is because men who are suffering from hair loss are an embarrassment to the rest of society.
    In a world filled with people who only show off the hair on their heads, hair loss is the glaring problem that everyone can notice. Even men who are well-groomed and have a lot of hair are not exempt from hair loss.
    It is important that men and women suffering from hair loss know that there are many ways to resolve the hair loss problem. This is why I have written this article.
    Now, I recognize that there is a lot of misinformation on the internet regarding how to cure hair loss. I have experienced this myself because I have been a victim of it. I have suffered from hair loss myself, and I
    have been searching for a way to cure it for about 4 years. Now I have finally found it. I am going to tell you how you can cure hair loss in the rest of this article. Minoxidil is one of the best hair lotions and it’s approved by the FDA
    its reactivates to the hair follicles and provides thicker and fuller hair.



  192. atommin on August 20, 2021 at 8:11 am

    Both Follica & Breezula have not started the FDA phase III yet, haven’t them?



    • Follicle Thought on August 20, 2021 at 1:41 pm

      No they have not.



  193. Ruben on September 3, 2021 at 6:02 am

    Dear Admin , thank you for your work and sharing these informations,
    Please keep your web site in live ;–)
    Best regards!!



  194. Sonic on September 4, 2021 at 10:17 am

    I’m really looking forward to hearing about the Phase 2 results of Kintors Pyrilutamide, which was said to be published by the end of the 3rd quarter of 2021, which is getting really close 😀

    Hopefully if positive, it can be submitted to the FDA and the FDA will allow Pyrilutamide to skip the Phase 2 in the US and move to the Phase 3



  195. Hope on September 22, 2021 at 7:39 am

    Does anyone know if Biosplice will be effective on woman or only men? The options are looking a little grim for woman right now unfortunately.



  196. Adam Saleem on October 6, 2021 at 6:58 pm

    I’m so happy to be the one to tell everybody that we found an organic treatment for hair lose. The product patent is in process and soon the baldness phenomena is going to be something from the past.
    Best regards.
    Adam



  197. Alan J on October 10, 2021 at 1:19 am

    Hi, it’s disappointing that Stemson has been pushed back from 2027 to 2029 for likely commercialisation (though hardly a surprise from reading the CEO interview). Also, Tsuji (so long on the list) is now absent, and we still don’t really know whether to get our hopes up. One would think that if he really had cracked it then investors would be lining up. But we will see; fingers crossed. There is no mention in the list of L’Oreal. I know they have been working with a specialised printing company since 2016, and have revealed some of their work (as reported here). I assume they are not willing to provide any specifics on likely timing; but I suppose it is not beyond the realms of possibility that such a major and well respected company could suddenly shock us all in a very positive way. Thanks as ever for all your work.



    • Follicle Thought on October 10, 2021 at 9:44 am

      Thanks Alan, I will look back into L’Oreal soon.



      • Alan J on October 20, 2021 at 7:43 am

        That would be great. Also, and apologies if I’ve missed an update, but do you know what the current position is with Triple Hair (of Canada)? The before and after photos from Spring 2020 (?) looked quite encouraging. I’m not sure if this is currently available, and if so whether it is working for anyone. Having tried many a porduct over the years, I’m now rather skeptical about anything you rub into the scalp, and am waiting (patiently) for hair cloning. But anything that is not too expensive and might slow down my loss is definitely worth a try (neither Minox or Fin worked for me, sadly). Thanks.



        • Follicle Thought on October 20, 2021 at 3:14 pm

          I don’t have an update from them at this time other than I believe they are raising funds for phase 3 trial.



          • Alan J on October 21, 2021 at 5:46 am

            Ok. Thanks. Fingers crossed….



  198. Follicle Thought on December 11, 2021 at 10:36 pm

    Before anyone asks why TissUse/JHewitt are not on the pipeline anymore lol: it’s simply because J Hewitt has stagnated a great deal lately. At first this was due to business logistics and then due to global health restrictions. As soon as things pick back up for them they will be back on the pipeline.



  199. Jade on December 20, 2021 at 6:17 pm

    Hi Follicle thought,

    Do we know if the product of Technoderma Medicines : TDM would be used for stopping hairloss or it would be able to regenerate hair? Like bringing a NW6 back to a NW2 for example?

    I have the same question for GT20029 from Kintor.

    Would the 2 drugs also be sideffect free?



    • Follicle Thought on December 21, 2021 at 10:32 am

      Jade, other than Moogene, I do not expect any topicals I know of to restore a NW6 to a NW2, that would be incredible. Most topicals work in a 2-Norwood range. It’s not possible to determine if drugs are side effect free until they are on the market. Most likely they will be side effect reduced.



      • Jade on December 21, 2021 at 5:13 pm

        Thanks Follicle Thought,

        Do we expect Technoderma Medicine’s TDM and GT20029 from Kintor to be for topical application?



        • Follicle Thought on December 21, 2021 at 5:22 pm

          Yes we do, Jade.



  200. Nick on January 30, 2022 at 2:44 pm

    Have you read the press release on Cassiopea of January 20th?

    “Breezula is under investigation in the United States for the treatment of androgenetic alopecia, and the safety and efficacy have not been established by the United States Food and Drug Administration (FDA). The proposed brand name for clascoterone solution 7.5% is not FDA-approved.”



  201. Nick on January 30, 2022 at 2:58 pm

    And Kintor seems to have entered phase III, which it expects to complete this year: https://www.kintor.com.cn/news/247.html



  202. d707 on March 1, 2022 at 6:46 pm

    Dermatologist recommended Revian Red Hair system but don’t see any articles on your site. Looks like they only have one company sponsored study though. Thanks.



    • Follicle Thought on March 1, 2022 at 6:51 pm

      I’ll take a look d707, did you see any impressive photo data from them?



      • d707 on March 1, 2022 at 8:10 pm

        revian.com/product/revian-red-system-for-us/

        Not super impressive and an expensive device. Sounds like one industry funded study so not sure much there. It looks like Stemson and dNovo might be the best options but of course years away from actual release. Thanks.



        • Follicle Thought on March 2, 2022 at 12:43 pm

          Yes, those results do not reach “the bar” for which I could consider writing about at this point. Stemson and dNovo, very interesting for sure.



  203. José on May 8, 2022 at 5:07 pm

    in the definitive guide you should put mayo. New users visiting the site might think it is outdated



    • Follicle Thought on May 8, 2022 at 10:42 pm

      Ok I changed it, Jose.



  204. John on September 16, 2022 at 4:56 pm

    What?

    GT20029 in 2027 (China)?!

    If the results of clinical trials are encouraging, it will be available in China in 2025.



  205. Cagri on October 19, 2022 at 1:37 pm

    is this page not updated anymore?



    • Follicle Thought on October 20, 2022 at 11:48 am

      Cagri, yes it’s still updated when possible.



  206. […] chart which represents the most promising and advanced hair growth treatments in the industry. The entire article will also continue to be updated this […]



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