2020 Hair Growth Therapies: A Look Ahead
In this article we will take a look at the most promising developments slated to occur in the hair restoration industry in 2020.
Clinical Treatments And Drugs For Hair Loss In 2020
TissUse & J Hewitt – TissUse’s hair regeneration therapy is known as the Smart Hair Transplant or SHT which has been in development since 2011. In a familiar format, the SHT method seeks to take about 30 hair follicles from the back of one’s head and turn them into thousands of hair producing cells via culturing. In early 2019, the Japan-based company, J Hewitt, obtained a license to commercialize the SHT procedure. In September 2019, the CEO of J Hewitt announced his plans to conduct a 5 patient SHT trial by the end of the year. Due to complications in preparing the trial with a contracted cell processing company, the start date is now scheduled for late January 2020. J Hewitt’s CEO has made it clear he is committed to taking SHT to trial and proving whether it works in a timely manner. This initiative is possibly the most exciting development in the hair growth industry currently.
Follica – Follica’s FOL-004 treatment is scheduled to enter a pivotal FDA study in 2020. If successful, this final study would allow FOL-004 to become approved in the US and likely in Europe shortly thereafter. The first result photos from Follica’s wounding + topical combination surfaced on the internet in late 2019 and left audiences intrigued. An early estimation for FOL-004 to reach market approval is Q1 2021.
Samumed – The lengthy phase 3 trial of Samumed’s SM04554 is scheduled to complete in June 2020. The company will receive data from over 600 patients who applied its topical Wnt activator SM04554 on a daily basis for roughly a year’s time. Pending results, this trial could lead to the commercialization of SM04554 in Turkey and potentially the US. If approved, the prescription treatment would not reach patients until 2021 at the earliest.
Follicum – In their last major update, Follicum announced it is aiming to begin a phase 2 trial of its newly formulated topical FOL-005 peptide in January 2020. The trial will last around 3 months, so results from this important phase 2 should be available by summer 2020. This will be the first time the peptide will be trialed topically, so results from this trial are particularly important. Follicum’s FOL-005 will be looking to match or better results from its topical peers Breezula and SM04554.
Dr. Tsuji & Organ Technologies – It is anticipated that Dr. Tsuji’s fabled hair cloning therapy will enter its first clinical trial in 2020. A commercial release for this treatment in 2020 is extremely unlikely even with Japan’s expedited regulatory process. However, if Organ Technologies produces a successful initial trial in 2020, the ‘Tsuji hair cloning treatment’ could theoretically become available to patients in Japan within the next few years.
Stemson Therapeutics – The California-based hair regeneration company is within the scope of starting a human trial in late 2020. After launching their website and announcing an investment by Allergan in June 2019, CEO Geoff Hamilton told the media the company expected to begin trials in “about a year and a half.”
HairClone – HairClone continues to strive towards offering its expanded dermal papilla cell injections in the UK. Funding is required to create an MHRA licensed facility in which HairClone could prepare its cell therapy. Depending on the company’s ability to raise funds and create a licensed lab space, the DP cell therapy could potentially become available to patients in the UK by the end of 2020.
Cassiopea – The company developing the topical anti-androgen Breezula met with the FDA on November 13, 2019 to discuss the launch of a phase 3 clinical trial. The trial is expected to begin in Q1 2020 and is slated to last 6 months. As of now, results from this trial are estimated to read out in Q4 2020 and could lead to market approval in 2021.
Shiseido & Replicel – Replicel has recently stated that it is engaging Shiseido about releasing results from the RCH-01 trial which took place in Japan. As the results were due in 2019, it is virtually impossible to think that the holdout can last much longer. One way or another we will get clarity or closure regarding Shiseido’s trial in 2020.
Cosmetic & Over The Counter Treatments In 2020
Giuliani Pharma – In September 2019, Giulani Pharma gave an exclusive update to Follicle Thought regarding the development of a WAY-316606 product for hair growth. We learned that the company decided to go for the cosmetic regulatory route and is researching several analog molecule equivalents to WAY-316606 to create a product with. According to a lead scientist at Giuliani, a small pilot human trial has been initiated with one of the candidate molecules and results are expected around the beginning of the new year. Regardless of how the first trial turns out, Giuliani has multiple molecules in their repertoire and is committed to seeing the research through. Look for an update on this development in Q1 2020.
Applied Biology – AB-103 is listed as a “minoxidil adjuvant therapy” on Applied Biology’s pipeline page. In late 2019, Dr. Andy Goren of Applied Biology told Follicle Thought his company is planning to release this product in the form of a shampoo. This shampoo is designed to help those who do not respond to minoxidil to get a response and is expected to enhance results in those who are already minoxidil responders. An estimated release of the product is Q3 2020.
Wild Card – There are always multiple companies quietly working behind the scenes on hair loss treatments. This is true at both the clinical and cosmetic level. However, the appeal of an effective cosmetic product is always higher due to the much shorter waiting period for such a product to reach the consumer market. When it comes to Wnt activating molecules and growth factor serums, there is potential to create an efficacious OTC product. Hopefully, in 2020 one or several companies who have been developing topicals over the last several years will finally unveil an exciting new product that will benefit many people.
Here’s to hoping for the best developments and some uplifting surprises for the hair seeking community in 2020.
Thank you, the J hewitt trial stands out as a big factor right now. When do you think results will come, July or Aug?
I would want to confirm with the company first, but those seem like reasonable dates. I would guess around September to know at least if the treatment works and results could improve past that timeline.
Nothing with aclaris therapeutics? They were the ones I was most excited for but they seem to have disappeared.
Jeff, Aclaris did pretty well in their trials but they are looking for a larger pharma co to continue the development for Jak inhibitors in AGA and AA. At this point we’re awaiting news of a collaboration or imminent deal.
Most looking forward to the Way cosmetic as well as the J Hewitt trial. I believe they have the greatest chances in each of their categories.
Thanks for the update! Very promising! Checked in on Histogen just for fun. As per usual, watching paint dry is still slightly more exciting.
Hello Admin, just wondering what you think of partial longitudinal follicular unit extraction by Dr. Coen Gho. Cheers
Things keep rolling along, good to hear. We need one to crack the seal, I see 2 or 3 on that list that could do it.
I think it’s safe to say that Shiseido’s RCH – 01 failed or else they would be screaming “SUCCESS!!” from the rafters by now.
This makes sense Russ, and another theory some ppl have said is that Shiseido is holding out on Replicel because they have a grudge about Replicel not fulfilling their end of the bargain. But if this was true, I don’t think they’d hold out forever. I give it 4 more months or so.
After this apparent modernization, we can say that 2025 will be the end of baldness.
who agrees with me?
What modernization are you talking about?
Admin, No mention about invitro hair?
Rdk, unfortunately I haven’t heard from them in a while and I’m not sure of their current plans. If I were to hear from them soon I would certainly edit the list.
Hi joseph,I’m 33 years old male have severe AGA. even my donor hair is also getting very thin day by day and shedding a lot,my elder brother is mostly bald and has very thin hairs in back and sides.does procedure like tissue SHT or tsuji helps in any manner to regrow hair in case if they are successful in near future?
Joe, I believe that theoretically a procedure like SHT should help if it does work. Adding the neopapillae to your scalp should improve your donor hair as well as your hair on top. Thinning hairs lack DP cells and adding the multiplied DP cells should thicken the hairs. It may be the case that someone with a thinning donor needs to get the injections done repeatedly to maintain the results, but I don’t see why it wouldn’t help.
I hope they are still pursuing a trial in 2020 as well, I’ve not heard from them in a while.
Is there any topical product that will be available in the global market in 2020..I’m expecting brezzula to be available in 2020
What About Medipost / Celino? Is it available now or very soon? Is this post from Saudi Arabia fake or true?
https://www.beautynailhairsalons.com/SA/Riyadh/158405414274341/MediPost-NGF37-Saudi-Arabia
I would like to hear from the readers here who have been trying the product. Michael? Others?
I’m not sure of the product’s availability, the company has a facebook page which I believe lists all updates.
Joseph, great work and much appreciated! It’s hard for an old guy like Yoda to keep all these potential treatments straight. 😉 I’ve forgotten about some and when posters rattle them off I can’t remember what they are. This is actually a good thing, due to that there are so many in the pipeline. Let’s all hope that something new that’s effective pans out soon.
Thanks for chiming in Yoda, I appreciate it. Fingers crossed for good things in the start of 2020.
I reside in Saudi Arabia; I contacted the company in Saudi Arabia and assured me that the treatment of NGF37 is mainly the treatment of skin aging and is currently used in clinics in Jeddah by injection for hair growth and that the NGF-574H tonic with the same active substance from umbilical cord cells but with a greater percentage; also He assured me that the efficacy of the product is three times more than that of minoxidil
The price of tonic is $ 150
The injection price is $ 200
What is admin’s opinion on this?
@ Ahmed Bekeer, thanks for checking.
@ Admin, when will Medipost be available in Europe? Or when starts Online Sale to order from South Korea?
I’m not sure John. I just checked the NGF facebook page for the first time in a while and I did not see any update about the overseas ordering website. I would guess the company is considering their options and any updates about ordering the product online will be shared through the official facebook page.
Still inviting users who tried the early bird NGF to share some words.
I think it’s in the middle east. I don’t think the middle east is safe for western citizens. Be careful.
Ahmed, I don’t believe the product was ever shown to be 3 times more than minoxidil. It would be great if the product was equal to minoxidil. The price of $150 for one bottle of tonic is certainly not inexpensive.
Follica results out!!! Guys good news!!!!
Follica talks about “Approved Drug” …. with Phase 3 start in H1/2020 this Treatment could be out 2021 I guess.
https://www.businesswire.com/news/home/20191218005795/en/Follica-Announces-Positive-Topline-Data-Clinical-Study
@Admin, I know I have asked for a Histogen/Allergan update before. But now you listed potential Treatments for next year. Can you please check this as well? Seems Allergan and Histogen work on a CCM Cosmetics since Summer 2017 now and Histogen Shows this as “Marketed” … SkinMedica
https://www.skinmedica.com/
https://www.genengnews.com/topics/translational-medicine/allergans-skinmedica-to-market-histogen-proteins-growth-factors/
https://practicaldermatology.com/news/histogens-growth-factor-technology-now-part-of-allergan-skin-care-line
John, the last we heard from Histogen they were seeking funding and mentioned during their investor presentation that they had funding which would carry the company into H1 2020. Hopefully they have secured additional funding by now or will soon. It would be optimal if Allergan would work something out with them and carry the HSC product through trials.
You forgot to mention Histogen. Phase 3 in Mexico will end in june 2020, like Samumed. The treatment will be available in 2021 in Mexico only.
Phase 3 in mexico fell through and never happened. There is a phase 1b for men planned next year.
2021 release seems very improbable.
It’s true, like Mattt said the phase 3 trial was never fully completed by Histogen’s partner in Mexico and eventually terminated. This was announced officially in a Histogen review article from earlier this year.
Shenzhen, I heard briefly from the company but there is no current update about the baldness cure or gray hair treatment but it appears the company has posted on their Twitter account about creating a Gmp compliant culturing media for dermal papilla cells. This will be used for their future treatments and is available for sale to other companies in 2020 according to tweet.
Should I hold off on a hair transplant? Was going to get one in 2020, but would waiting 5 years be better? Right now they have the DHI and Sapphire blade FUE. Are we on the cusp of changing how transplants are done?
Well, there are several techniques which are looking to change the ability of hair transplants (to create unlimited donor or close to unlimited donor) but none of them should be available for consumers in 2020. We hope for the best, but we don’t know when they will actually be available. Waiting to see how one of the first clinical trials goes for the next gen treatments may be an idea for you. Make sure you weigh all of your options and give it a lengthy consideration.
Thank you for your info and posting this. I had a consultation and I am a good candidate for the Sapphire blade FUE transplant. I was going to get it in Feb, but maybe I should wait until 2021 and see what’s developed. Part of me wants to get it now, as I have the funds and time, but another side says wait it out.
Good article. It looks like an interesting year ahead for the hair growth industry.
@ADMIN: When will you get in contact with Jon Knight and ask him:
1. Will The trial truly start at the end of january 2020?
2. how long the trial will last?
Thank you!
Hi, I don’t plan on emailing J Hewitt until late January if I don’t hear from him by them. I know he’s actively working on the trial with a third party company like he said he is and I’ll let him get it all sorted out.
Next time I speak to him I will certainly ask how long the trial will last because this is an important question.
but what happened to invitro hair? are they still going to pursue the hair follicles and melanocytes? this was said in previous article comments.
I am also wondering this. They seemed like one of the most promising companies
This hair loss article about DSC’s appeared on Google’s front page:
https://www.google.com/amp/s/medicalxpress.com/news/2019-12-hair-growth-baldness-optional.amp
Thoughts?
Thanks for sharing Greg.
Obviously this scientist don’t know RCH-01 by Replicel/Shiseido.
This makes it even more interesting about hearing of the RCH-01 Phase II results!
What I find exciting about this article is not what it talks about but rather that hair loss cures are becoming a more mainstream topic – as this article was shown, and is still being shown in Google’s homepage as of me writing this comment. I think that if the level of exposure to a greater audience continues it’ll speed things up in general. What do y’all think?
Greg, was google showing the news on its homepage because of your search history? Or was it on the home page for all viewers? Google is highly tailored to their audience’s search habits.
It really doesn’t matter for me if hair loss cure is a mainstream topic or not.
RCH-01 was tested by SHISEIDO and the results of Phase II will be posted soon or not.
For me it only matters if this data is satisfied and SHISEIDO brings RCH-01 to market in 2020. the article you posted shows that dermal sheath cup cells are playing a significant role in hair growth so it is good
@Admin what do You think about Greg’s link about DSC. Is this a good sign for RCH-01?
Thanks
There’s a difference between sheath cells and the sheath muscle. There is no evidence that injecting sheath cells will have any effect on the sheath muscle.
Also, RCH-01 is cultured sheath cells, without DP cells, AND WITHOUT HAIR INDUCTIVITY RETENTION during culture. I do not see any chance of this working and I think that’s why Shiseido has been silent about their results.
I think there are business issues with Replicel that are the reason for not publishing the data.
To be fair no one has proved yet that a dp cell is better than a ds cell. One or both could be good for growing hair if they are cultured properly. Your theory about shiseido could still be correct obv…
Greg, thanks for sharing. I saw the article on Google as well and thought I had sent a reply to this earlier. This research is interesting and presents another potential target for helping hair grow.
In this case, Rendl and his lab members think that applying drugs which prevent muscle contraction could keep hair growing and prolong the anagen phase. It’s a sound approach and will not be hard to test and prove. It sounds like something that Ralf Paus would be studying at his lab. Be on the lookout for repurposed drugs to be tested for this indication. Similar to WAY-316606 and its ability to inhibit SFRP1.
Thanks for the input admin, but I really only follow cell therapies – not that I wouldn’t use a drug that gives you back all your hair and more. But IMO drugs will just always be “drugs” if you catch my drift, unless you’re talking about something like Exicure but I’m more looking forward to therapies such as TissUse and tsuji and that whole bunch. Realistically, which half of the industry do you think has a better chance in the future, or now?
Greg, I agree that cloned follicles have a much greater capacity to reverse baldness and thus are more interesting to many people. But, I don’t count out drugs because preventing hair loss is a superior method than re-implanting cloned follicles to a lot of people. In the near term future I think additional drugs will help like SM and Breezula; TissUse has a shot to join the party, and in the more distant future both cloned follicles and drugs will do well. No one can really estimate which will come first between 1) a working cloned follicle therapy or 2) an extremely powerful drug which can either totally prevent hair loss or regrow a meaningful amount of hair.
Hi! What´s Follica´s FOL-004 treatment about? Is it a pill, a lotion or just the device?A lotion and the device? Still don´t get it, but I would say that Samumed is our only chance right now. Let´s see if this works… Do you think we will see photos before September chief? Thanks in advance 🙂
Alonso, Follica is a device which creates skin disruption at an in-office procedure. It supposedly only takes about 5 minutes at the office. Then, there is subsequent application of a topical (likely minoxidil, could be a mix as well). It’s somewhat unclear how much skin disruption follows in the at-home portion of the FOL-004 treatment.
Too early to guess about Samumed photos in Sept, possible but I think the wait will be longer to be honest.
Many thanks Joseph, with out a doubt this is the best web page to get upates form the industry. Great hollidays.
Thank you Antonio, I appreciate it. Happy Holidays to you!
Does anybody have problem in connecting to hairlosstalk???
Does their site have any kind of problem??
Thanks in advance!
@vlassis yes I get a problem with their certificate too. I’ve not been visiting because google says the site is a risk. Must be more people who experience this too?
So there are other users too….
Admin do you have normal access to the site, ?
Can you convey this message to their Admin please. ?
Yep, I can´t see the website as well. I was worried because Mozilla told me HairlossTalk was a risky place to visit. Glad you shared that 😉
just keep hitting advance, nothing is wrong. Admin just needs to update their license
Merry Christmas Follicle Thought and everyone else.
Thanks Russell, Merry Christmas!
Admin, any update from tsuji yet? I know it was said that they would have an update in December but it ain’t looking like that. Possibly in the coming weeks?
No update from Tsuji yet and it’s hard to tell when it will be, Greg. Everyone would love an update in the coming weeks but I have not been personally in contact with the company so I have no hunch in this case.
Oh well. I guess they’ll update us when they will. More looking forward to start of TissUse trial. I guess if we don’t hear from tsuji soon then we’ll hear from them when they give us their test results for their trail.
On that note, I heard tsuji and his team were doing human experiments this year? Any truth to that? I heard that info came out with the alleged price for his treatment.
Cotsarelis, George
http://www.freepatentsonline.com/y2019/0380942.html
I thought the PGD2 angle was dead.
PGD2 blocker angle is still viable, people had good results with topical setipiprant etc, but Allergan chose to trial a PGD2 blocker orally. There’s also the potential for better and more efficient PGD2 blockers to be developed as well. It’s similar to the differences between finasteride, dutasteride, and clascoterone (Breezula).
In this case, the patent is just being updated with some new claim or adjustment which could be meaningful or not that important, it just adds IP protection to Cotsarelis. I think if setipiprant was trialed topically it would have been a success for Allergan.
I will put all of the above in my pipe dream folder.
I will believe it when I see outstanding results.
In the meantime I wont hold my breath as it’s been nothing but talk and no action for decades!
Sadly, I have to agree with Peter. I am starting to feel worn down with the breaking news and how some stories mention they have the cure, yet these “discoveries” seem to lay dormant for decades and don’t make it to market,
I still check, but have learned to view it from a more skeptical perspective so I don’t need to constantly be let down.
Don’t give up hope Lisa 🙂 We know to be tempered with our expectations when the latest news comes out but there’s got to be a breakthrough at some point.
Cotsarelis still talks about mice, so we are screwed guys! By the way, how is it that HLT doesn´t yet work?
Because the admin on hlt doesn’t care about it. I wish everyone migrated to a new hair loss forum
You mean like a new hair loss forum like this site A? 🙂 Joseph actually gives a darn about his forum, let’s people post more or less without restriction but keeps the loony tunes, racists, homophobes, conspiracy theorists and down right nastiness outta here for the most part. BTW early Happy New Year/ New Decade to you Joe and everyone! We surely won’t be in the same place with hair loss by the end of this coming decade, most probably much sooner than that. Stay positive!
I agree. Lot more promising stuff going on now than in ten years ago. Hopefully we’ll get an idea of the major cloning companies’ whereabouts over the course of the next year with their trial updates.
I’m really hoping that a cosmetic topical that even works moderately would come out in 2020, I think people would be happy with that. Looking forward to hearing more from Giuliani in the next months.
Is the cosmetic topical realistic? Seems to good to be true.
Some advice from a molecular biologist.
I would not suggest exposure to a Wnt inhibitor (oral or topical) without large, double blind toxicity and efficacy trials. Wnt is a massive cellular target involved in numerous biological pathways in many organs. The same goes for immunosuppressive targets and drugs like Cyclosporine A. Yes they can grow hair like mad, I have seen it, but they come with the risk of serious infection? Full head of hair with tuberculosis? No thanks.
Topicals do go systemic and anyone that tells your otherwise is either clueless or not being forthright. Just read some of the hair loss board forums from men taking Brotzu and experiencing massive shedding without regrowth and in some cases anecdotes of feminization (i.e. budding breasts, testicular pain).
What I look for is development of a peptide or small molecule targeting hair growth specific pathways and cell types, especially dermal cup progenitor cells. Still, the challenge with this approach is that we don’t fully understand the genetics of garden variety androgenic alopecia, which has proven to be a formidable challenge in finding a drug or drug cocktail that safely and robustly stimulate hair growth and overcome someone’s genetic endowment for hair loss. We have seen all too many amazing “results” photos with no real movement from pre-clinical testing.
I think the next 2 years will be telling on the potential for development of oral and topical small molecules for treating hair loss. However, I fear that if these new targets/drugs fail to produce meaningful results in large trials, I am afraid investors and funding agencies will go dormant for some years before coming back to this in a robust way. Research also moves in business cycles and is very trend-driven.
Cloning technology and organoid generation i.e. RIKEN, Tsuji, remains a big outlier here.
If they can work out how to scale up this technology and demonstrate that cloned hairs behave as natural hairs after transplant in humans, this would be a game changer because it would then open up new ideas and drive that technology forward.
My only issue with this approach is that it will still require surgery and the skill of the surgeon’s hands (and ego). I find the whole world of hair transplant surgery somewhat sleazy and fraught with risk and outdated techniques. There are plenty of patient self-reports of terrible unnatural looking transplants.
Ideally, I would like to see a 21st century technology for hair loss remove the need for surgical intervention.
In the mean time men should do whatever they can to hold on to the hair they have while we wait for the science to be ironed out. I have had a lot of success with topical finasteride compounded into minoxidil.
Alex, where do you source your topical finasteride from? I was thinking of giving it a try
CareFirst Specialty Pharmacy in NJ.
As a molecular biologist,
What is your opinion on cell therapies like RCH-01 or using DP cell injections?
It has been known for almost 20 years and well documented that within the dermal cup sheath of the dermal papillae exists a population of multi-potent stem cells which participate in maintenance and in some cases regeneration of the hair bulb.
As with all regenerative medicine technologies, the challenge is to harness the potential of these cells ex vivo by scaling up the cell numbers while keeping them in a multipotent state. Generating large enough numbers (i.e. millions) of pure multipotent cells ex vivo is in itself a huge technical challenge. I worked on generating insulin producing beta-cells from stem cells for years, and yields of functional beta cells after ectopic implantation into the portal vein of the liver by me and others has remained unimpressive.
In a pure stem cell population outside of their biological niche environment ex vivo, many cells will begin to spontaneously differentiate into any number of cell types in their multipotent program.
I suspect that the unimpressive yields we have seen with RCH-01, and undoubtedly why Sheishedo is holding back their data, is because they have yet to figure out how to get a critical mass of DCS cells with undifferentiated stem cell populations ex vivo, AND equally important, figure out how to harness the regenerative program of these cells after reimplantation. The question always exists in the lab. “Ok we put the cell back in, but will they actually grow hair and how many”
Regenerative medicine from the perspective of using the pluripotent potential of stem cells has not produced the translational therapies that were predicted 20 years ago for the reasons I point out as well as others on a tissue and disease-specific basis.
I always say to my students, yes that was a long answer to a simple question, but science is always more complicated than yes or no. Right now I am not optimistic that RCH-01 injections will go anywhere anytime soon. I suspect Sheishedo will shelf this RCH project, at least in the public’s view, and go back to the drawing board on this technology if at all give the many other angles one can try to stimulate hair regrowth.
Again, as a balding scientist, my advice is to do whatever you can to hold on to the hair you have (within reason) and watch as the next 2-3 years will be very telling as many of these small molecule trial results will have to put up or disappear into the dustbin of hair loss trial history.
The alternative is just to accept your hairless and be free of this selfimposed obsession with having a full head of hair. Maybe we just need to ask ourselves on a deeper level why the obsession. I envy men who walk with a bald head and confidence. That is the best cure we all can hope for.
Why is someone not continuing with setipiprant in topical form? I thought follica was also associated with cotsarelis as well
seems like clinicaltrials gov updated samumed sm04554 page and it now looks like that the trial is estimated to end in january 2021. Let’s be hopeful and see how the results are going to be.
This is one of the best articles I have seen in a long time! Thank you for sharing~
No way! January 2021? That´s worst than I thought, oh gosh! June was better than this… It´s always the same, we´ll never make it :s
Alonso, you are wrong . samumed has just completed the number of required participants which i assume is 625. And now all of them are using the topical solution, and a year mark is nothing but a relevant period from which they will conclude how great is sm04554 compared to existing topical aka minoxidil. by the end of next year you’ll know whether or not this thing works. One year is nothing to your hair follicles they will still be alive. just get on existing meds and you’d be alright.
Then thanks! But soon I´ll be 10 years on forking finas, so I guess that I´m tired of waiting. Like most people have, but there´s nothing I can do about it. Thought that we will now by June, that´s all. Gonna take it easy anyway =)
does anyone have any contact with shiseido? whats happened
Is there anything relevant with CRISPR??
CRISPR is good at editing sequences of a single gene, with promising results for single-gene diseases such as sickle cell. However polygenetic conditions such as male pattern balding, where there are multiple genes at play, CRISPR is a long way off.
seems promising
https://www.youtube.com/watch?v=6sCNVOggOs0&lc=z235y5kotk2eczvu4acdp432zyhxkbbzln2khmwvj1xw03c010c.1577742325390866
Thank you for sharing DragC, it’s appreciated. Are you using the product?
no, because it ;s not available for sale officially; but…I could be interested
I thought medipost was fake?
I have to say those results are honestly impressive for the guy, he seems to have a response! Is there anyone else with a response??
Hey admin- have you heard any news regarding Kerastem. They got good results from their USA phase 2 last year. Any news on their phase 3 trial start date?
Hi Hairguy, I have not heard much news about Kerastem’s phase 3, although the treatment is available in Europe which is a popular place for medical tourism and there doesn’t seem to be much of a buzz about it. Adipose-derived stem cell injections have been taking place in the US for some time now as well and there doesn’t seem to be a big response to those treatments.
Thanks for the update admin. Looks like it was a hype treatment. Ken Washenik is a key member of Kerstem and Follica. Both claim 30 hairs cm2. Kerastem mention 17% increase hair growth but Follica 40% but both claim 30 cm2 hair growth. ? Confused on the math here lol. I hope Follica doesn’t end up like kerastem with little regrowth and all hype.
@Admin happy new Year! Theoretical we should know much earlier if SHT works I think.
If trials start in End of January then the participants give their hair biopsy and the cells will be multiplyied within 4 – 5 days. After that the surgeon will implant the SHT. So The neopapille will be injected in mid February 2020. I assume early results of this injection could be seen already in March 2020
What do you think?
What does Jon Knight really mean with „patients have hair biopsies, and then return in 45 days for injection“
Do patients have to wait 4-5 days or 45 days(1,5months) for injection?
It means that the patient needs to get biopsies taken and then have the cells cultured properly for 45 days and then receive reinjections.
Arol, if everything goes smoothly perhaps injections would be done around mid march, Knight mentioned that it would take about 45 days for the culturing process.
NO answer to the question. It seems like 2020 nobody minds hairloss
i don’t know if Alex ( bilogy professor ) is still reading this, but i have a question for you :
SM04554 is a wnt pathway activator , and yet you claim that a wnt pathway activator is dangerous for our health. But , don’t you see the dosage of the wnt activator is very minimal and that it is still given as a topical treatment. Do you think that this type of danger is still to be possible even though the dosage is small ? Thank you for enlightening us 🙂
I think this year is low-key a pivotal year for a lot of early stage MPB sufferers. If RCH-01 ever gets released and can prevent one from losing more hair on their head (even if it doesn’t regrow much new hair), people (like me) would get a new hairline transplanted and probably be happy with that. It’s discouraging to me that something exists right now that would literally change a lot of people’s lives but isn’t being released because of some ridiculous dispute. I want to have faith in RCH-01 but the lack of transparency is concerning to me, not trying to be negative. But, if at some point this year we can at least get some details and results from their trials that prove the products efficacy, and a statement of where the company plans to go from there, it would be encouraging. Basically, if RCH-01 does it’s jobs and stops hair loss, OR Tissuse’s SHT produces results that exceed the expectations of RCH-01, there will be a lot of excited people, and this should be a type of “cure” for a good portion of people with hair loss. Any estimated time for Replicel/Shiseido to release any info?
We must be sure in case RCH-01 is released and know that it works also to rejuvenate miniaturized hair. If not, you may lose some of your miniaturized hair after a graft. I hope that Tissuse can do this and generate a significant percentage and once secured the miniaturized hair will return to its natural state, after this if a FUE graft would be an option.
Big L, it’s hard to say, we know Replicel is pressuring Shiseido to release results but I don’t know if Replicel has any power to really make them do it.
In my opinion, the most sensible route in treating hair loss would be trying to activate existing follicles again. However, many treatments under development seem to focus in moving new follicles to areas that have gone bald. If someone would figure out how to kick start miniaturized and dormant follicles again it would make surgery unnecessary and guarantee natural looking hairlines.
Hairclone is treating that because of what I read about them. But I think only if the follicle signaling is active. The follicles that have already closed their pores for a long time I think it would be impossible
Yeah but unfortunately they are at least a year away and before knowing if it even works at least 2 years..
RCH-01 tries to develop a miniturized hair in terminal hair. We need a sign of Shiseido. Maybe they wait until launch with their results. It should be out in 2020. If 2020 RCH-01 doesnt commercialize i think they have failed the trial
admin
It is time 2020 to activate any new medicine for the treatment of baldness
HEy Admin there is an interesting update of Organ Technologies on their website:
http://www.organ-technol.co.jp/en/business/hair-follicle-regeneration/
THey will offer 3 different treatments. I hope that clinical trials for the 1. generation treatment with multiplied Dermal Papilla is ready that they can commercialize this year like planned
Check I t out
Klaas, thanks for sharing. That information has actually been on the Organ Technologies website for over a year or so, but it is a very interesting point. I’m hoping for more updates from Organ Technologies within the next few months.
https://www.orlandohairclinic.com/exosomes-hair-restoration/ ,Hi I saw this link on hair 2020. Question do you have more information about this product admin?
While we wait on a viable treatment, can anyone recommend a concealer that actually works?
I use Derm Match, Bouffe Spray and Jamie Steven’s products, but I don’t think anything actually looks decent in daylight or under bright light. Is there anything?
Hey Admin!
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It may be 2020 and we may not have any new treatments or cures (yet), but i want to thank you for keeping us up to date with the latest hair loss news. I began receding at the mere age of 15 and FT has been my got to source for the latest hair loss news since 2015.
I don’t expect any commercially available cure in the short term (1-3 years) but hopefully we do get a commercially viable cure by 2025.
Admin: When do You want to talk to your contact at SHISEIDO? We must know what’s going on!! Probably the medical institutions (Tokyo Medical University), Jiro Kishimoto, will publish the data
Anil, the contact I had for the Shiseido trials is no longer responding to questions about the trial.
Thank you for the article guys! I’m a 25 y.o. female with very thin hair from the nature. Do you think it is possible that one of these treatments will be able to help me?
Yulia, certainly some of these treatments could help you but it depends on their release dates. At the moment, I think HairClone and TissUse’s treatments would potentially create the best regrowth for a person with thin/thinning hair. Please stay tuned for updates, I wish you all the best.
Hi Admin,
Do you still think Applied Biology’s shampoo will come out this quarter?
If I had to guess I’d say no Katy, the last I heard from Dr. Goren he said still this year, so we’ll see. I think maybe Oct or Nov.